Mitomycin
Uses of Mitomycin
Mitomycin is primarily used in cancer therapy to manage and provide relief from symptoms of advanced or metastatic stomach, breast, and pancreatic cancer and it belongs to antineoplastic agents medications.
It is also used to manage cancers of the neck, respiratory tract, cervix, and rectum. Additionally, it is employed to treat the recurrence of bladder cancer following transurethral resection (surgery).
Side effects of Mitomycin
Decreased blood cell counts
Nausea and vomiting
Loss of appetite
Diarrhoea
Mouth sores
Hair loss
How Mitomycin works
Mitomycin is an antineoplastic chemotherapy medicine.
Once it is activated in the body, Mitomycin alkylates and cross-links DNA. This process prevents the DNA strands from separating, which in turn inhibits the replication of DNA. This action is particularly effective against rapidly dividing cells, such as cancer cells.
In addition to this, Mitomycin generates oxygen radicals that cause breaks in the DNA strands. This disrupts cell growth and also inhibits the synthesis of RNA and proteins.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BDS, PGCAD, GMHE (IIM-B)
Expert Advice
Dosage Forms Available
Mitomycin is available as a powder and solution for injection or infusion and is administered intravenously.
Age and Dose Restrictions
Mitomycin is meant for adult use only.
The dosage depends on the patient's body size, type of cancer, and individual response to treatment.
Contraindications
Mitomycin is contraindicated in patients with known hypersensitivity to it.
It is also contraindicated in patients with thrombocytopenia, leukopenia, or significant anaemia.
Other Medications to Avoid
Mitomycin may interact with Cytotoxic Agents (e.g., cisplatin, doxorubicin), Anticoagulants (e.g., warfarin), Other Chemotherapeutic Agents (e.g., carboplatin, paclitaxel), Glycyrrhizin-containing Products (e.g., liquorice).
Overdose and Missed Dose
Chances for overdose are less as it is administered to you by a healthcare professional. However, an overdose of Mitomycin may result in severe bone marrow suppression, leading to infections. If you suspect an overdose, immediately consult your doctor.
If you miss a dose of Mitomycin, consult your healthcare provider for the next dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For nausea and vomiting, try taking this medicine with food.
To manage diarrhoea, drink plenty of fluids to avoid dehydration.
For mouth sores, maintain good oral hygiene and use a soft toothbrush.
Use in Driving and Operating Machinery
Mitomycin may cause fatigue and weakness, which could affect your ability to drive or operate heavy machinery. It is advisable to avoid such activities if you experience these side effects.
Use in Pregnancy and Lactation
Mitomycin can cause harm to the foetus; hence, its use is not recommended during pregnancy.
Breastfeeding is also not advised during treatment with Mitomycin due to potential harm to the infant.
Always consult your doctor before administering this medicine during pregnancy and lactation.
Caution in Other Conditions
Patients with impaired kidney function should exercise caution while administering this medicine.
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet rich in fruits, vegetables, and lean proteins to support overall health during cancer treatment.
Adequate hydration is crucial to help manage side effects such as nausea and diarrhoea.
Rest and relaxation techniques can help manage fatigue associated with cancer treatment.
Regular light physical activity, as your doctor advises, can boost energy levels and overall well-being.
Frequently asked questions
Is Mitomycin a natural compound?
Yes, Mitomycin is derived from the bacterium Streptomyces caespitosus. Despite its natural origin, it is a powerful medication with significant effects on the body.
Will Mitomycin affect my mood or behaviour?
Mitomycin primarily targets rapidly dividing cells, such as cancer cells. While it does not directly impact mood or behaviour, its side effects, such as fatigue, nausea, and loss of appetite, could indirectly affect your mood. If you notice any significant changes in your mood or behaviour while taking this medicine, discuss them with your doctor.
Could Mitomycin lead to dependency or withdrawal symptoms?
Mitomycin does not cause dependency or withdrawal symptoms. It is an anti-cancer medication and not classified as an addictive substance.
Does Mitomycin interact with any foods?
There are no specific food interactions with Mitomycin. However, given its potential side effects, such as nausea and loss of appetite, you might need to modify your diet to manage these side effects. Your doctor or dietician can provide more detailed guidance.
How long does Mitomycin stay in the body?
The exact duration that Mitomycin stays in the body can vary from person to person. It depends on factors like the dosage administered, the frequency of use, and the individual's metabolism.
Is there any alternative to Mitomycin for treating cancer?
Many different medications are available to manage different types of cancer. The choice of alternative medicines depends on the type and stage of cancer, individual patient characteristics, and response to treatment. Always consult your doctor for the best treatment options for you.
Can I buy Mitomycin over the counter?
No, you cannot buy Mitomycin over the counter. It is a prescription medicine used to manage serious conditions like cancer and should only be used under medical supervision.
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