Methylergometrine
Uses of Methylergometrine
Methylergometrine is primarily used to manage postpartum haemorrhage, defined as excessive bleeding after childbirth, and belongs to ergot alkaloids.
Additionally, it is used to manage uterine atony (a condition where the uterus fails to contract adequately after childbirth, leading to excessive blood loss). In some cases, it may also be used to induce or augment labour contractions.
Side effects of Methylergometrine
Nausea
Vomiting
Abdominal pain or cramping
Headache
Dizziness
High blood pressure
How Methylergometrine works
Methylergometrine is an uterotonic agent (medication given after childbirth to help the uterus shrink back to its normal size to prevent excessive bleeding) and an ergot derivative.
It acts directly on the smooth muscles found within the uterus. This action stimulates and sustains uterine contractions. These contractions help to increase the tone, rate, and strength of rhythmic contractions within the uterus. This leads to a rapid and prolonged uterotonic effect. This uterotonic effect helps to squeeze the blood vessels in the wall of the uterus. This squeezing action reduces blood loss and helps stop bleeding.
Methylergometrine also boosts the effects of natural substances in your body called prostaglandins, which also help to contract the uterus.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Methylergometrine can be taken in intramuscular (injection), intravenous (injection) and orally (tablet) routes.
Age and Dose Restrictions
Methylergometrine is generally used in adult women, particularly during childbirth. It is not typically given to children or men.
Contraindications
This medicine is contraindicated in patients allergic to ergot alkaloids. It is also contraindicated in people with certain medical conditions such as high blood pressure, heart disease, peripheral vascular disease, or Raynaud's syndrome.
Other Medications to Avoid
Methylergometrine can interact with other ergot alkaloids (e.g., ergotamine, dihydroergotamine), azole antifungals (e.g., itraconazole, ketoconazole), macrolide antibiotics (e.g., erythromycin, clarithromycin), and "triptan" migraine medications (e.g., rizatriptan, sumatriptan).
Overdose and Missed Dose
An overdose of this medicine can cause symptoms such as nausea, vomiting, abdominal pain, headache, and dizziness. If this happens, you should consult your doctor immediately.
If you forget to take a dose of this medicine, take it as soon as you remember. But if your next dose is due soon, skip the missed dose and return to your regular medication schedule. Do not take a double dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Avoid sudden changes in posture to avoid dizziness and lightheadedness.
Use in Driving and Operating Machinery
Methylergometrine can cause dizziness. This means it may affect your ability to drive or operate heavy machinery. If you feel dizzy after taking this medicine, do not drive or operate machinery until you feel well enough.
Use in Pregnancy and Lactation
This medicine should not be used during pregnancy as it can cause uterine contractions that could harm the unborn baby. It should also be avoided or used with caution during breastfeeding due to the potential for it to affect the nursing infant. Always consult your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
People with certain medical conditions, such as kidney or liver problems, should be cautious when using Methylergometrine.
Special Dietary and Lifestyle Recommendations
Do not eat or drink grapefruit products, as they may increase serum levels of Methylergometrine.
Frequently asked questions
Can Methylergometrine be given after a cesarean section?
Yes, Methylergometrine can be given after a cesarean section to help control postpartum hemorrhage (excessive bleeding after childbirth).
How quickly does Methylergometrine start to work?
Methylergometrine is rapidly absorbed after administration and starts to work quickly. However, the exact time it takes to work can vary based on different factors. Consult your doctor for more information.
Can I take Methylergometrine if I have high blood pressure?
Methylergometrine should be used with caution in patients with a history of high blood pressure or cardiovascular disease. Always consult your doctor before starting any new medicine.
Can Methylergometrine affect my mood?
While there is no direct link between Methylergometrine and mood changes, being unwell can sometimes affect your mood. If you have concerns, consult your doctor.
How should I store Methylergometrine?
Methylergometrine should be stored at room temperature, away from light and moisture. Always keep medicines out of reach of children.
Can I stop taking Methylergometrine if I feel better?
No, you should not stop taking Methylergometrine unless advised by your doctor. Even if you feel better, it's important to finish the full course of treatment to ensure the condition is fully managed.
What should I do if I am allergic to Methylergometrine?
If you think you may be allergic to Methylergometrine, stop taking the medicine and consult your doctor immediately.
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