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Memantine

Uses of Memantine

  • Memantine is used to manage moderate to severe dementia associated with Alzheimer's disease and belongs to a class of medications known as NMDA receptor antagonists.

Side effects of Memantine

  • Dizziness

  • Headache

  • Hallucination

  • Constipation

  • Tiredness

How Memantine works

  • Memantine is classified as an NMDA receptor antagonist.

  • It works by controlling the activity of glutamate, a neurotransmitter involved in memory formation and learning processes. Overactivation of NMDA receptors by excessive glutamate can damage neurons, a condition associated with Alzheimer's disease. Memantine binds to these receptors when they are excessively activated, blocking their activity. This action prevents overstimulation of nerve cells, helping to slow down memory loss and cognitive decline in Alzheimer's patients.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Memantine is available for use via the oral route in immediate-release tablets,extended-release (long-acting) capsule and oral solution.

Age and Dose Restrictions

  • Memantine is meant for adults and elderly patients, specifically those diagnosed with moderate to severe Alzheimer's disease. It is not recommended for children or adolescents. Always consult your doctor and adhere to the prescribed dose.

Contraindications

  • Memantine is contraindicated in patients who have recently experienced a heart attack or if they are suffering from congestive heart failure. This medicine should also be used cautiously in patients with severe renal impairment or a history of seizures.

Other Medications to Avoid

  • Memantine may interact with other NMDA receptor antagonists (e.g., amantadine, ketamine) and anticholinergics (e.g., dimenhydrinate, clidinium).

Overdose and Missed Dose

  • An overdose of Memantine may lead to side effects such as restlessness, shortness of breath, high blood pressure, and loss of consciousness. In case of a suspected overdose, consult your doctor immediately.
  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and return to your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.

  • To manage dizziness or drowsiness, try taking Memantine at bedtime.
  • Ensure adequate fluid intake to prevent constipation.
  • Rest and avoid sudden movements in case of dizziness or confusion.

Use in Driving and Operating Machinery

  • Memantine may cause side effects such as dizziness or drowsiness which can affect your ability to drive or operate machinery. Hence, you should avoid these activities if you experience such symptoms after taking this medicine.

Use in Pregnancy and Lactation

  • This medicine is not recommended during pregnancy or breastfeeding. Always consult your doctor before using this medicine during pregnancy or breastfeeding.

Caution in Other Conditions

  • Patients with severe renal impairment should exercise caution when taking Memantine as they may have significantly higher drug exposure compared to patients with normal renal function. Additionally, patients with a history of uncontrolled hypertension should be cautious while taking this medication.

Special Dietary and Lifestyle Recommendations

  • Engage in regular mental exercises such as puzzles, reading, or learning a new skill to stimulate cognitive function.
  • Ensure adequate hydration to help manage potential side effects like constipation.

Frequently asked questions

No, Memantine is not an antidepressant. It is classified as an NMDA receptor antagonist and is specifically used for the management of moderate to severe Alzheimer's disease.

Memantine is specifically indicated for improving memory and cognitive function in patients with moderate to severe Alzheimer's disease. There is no concrete evidence to suggest that it can enhance memory in individuals without this condition.

Weight gain is not typically associated with the use of Memantine. However, individual responses can vary, and any unexplained weight changes should be discussed with your doctor.

While it is not common, some patients using Memantine may experience mood changes or behavioural changes. If you observe any significant mood swings or changes in behaviour, you should consult your doctor immediately.

The use of Memantine is not recommended for children and adolescents under the age of 18 years.

The formulation's contents can vary among manufacturers, so it is best to check the product label or consult your pharmacist to determine if a specific brand of Memantine is suitable for vegans.

It is advisable to consult your doctor before stopping any medicine. Abrupt discontinuation of Memantine may result in withdrawal symptoms or worsening of symptoms.

Terms & Conditions


Memantine in other salts

Available medicines for MEMANTINE
Admenta 5 Tablet 10
Admenta 5 Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹108.24
MRP ₹132.00
18.00% OFF
Admenta 10 Tablet 10
Admenta 10 Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹189.01
MRP ₹230.50
18.00% OFF
Nemdaa 10 Tablet 10
Nemdaa 10 Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹168.51
MRP ₹205.50
18.00% OFF
Mentatime 10 Tablet 10
Mentatime 10 Tablet 10
Steris Healthcare
Pack of 10 Units
₹85.83
MRP ₹172.00
50.10% OFF
Dmentin Md 10 MG Tablet 10
Dmentin Md 10 MG Tablet 10
Micro Labs Ltd
Pack of 10 Units
₹77.90
MRP ₹95.00
18.00% OFF
Almantin 5 MG Tablet 10
Almantin 5 MG Tablet 10
Sun Pharmaceutical Industries Ltd
Pack of 10 Units
₹39.36
MRP ₹48.00
18.00% OFF
Nemdaa 5 Tablet 10
Nemdaa 5 Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹88.15
MRP ₹107.50
18.00% OFF
Menta Time 5mg Tablet 10
Menta Time 5mg Tablet 10
Steris Healthcare
Pack of 10 Units
₹41.67
MRP ₹83.50
50.10% OFF

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