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Linagliptin

ANTIDIABETIC

Uses of Linagliptin

  • Linagliptin is used for managing Type 2 Diabetes (T2DM) along with diet and exercise.
  • It functions to augment postprandial insulin secretion and diminish endogenous glucose production in the body. 

Side effects of Linagliptin

  • Sore throat
  • Runny or stuffy nose
  • Cough
  • Diarrhea

How Linagliptin works

Linagliptin is an inhibitor of DPP-4, an enzyme that breaks down incretin hormones, namely glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Consequently, linagliptin elevates the concentrations of active incretin hormones, promoting insulin release in a glucose-dependent manner and reducing circulating glucagon levels. GLP-1 and GIP play vital roles in the physiological regulation of glucose homeostasis. Incretin hormones are continuously secreted at basal levels throughout the day, with levels surging immediately after meal consumption. GLP-1 and GIP enhance insulin biosynthesis and secretion from pancreatic beta cells, particularly in the presence of normal and elevated blood glucose levels. Additionally, GLP-1 diminishes glucagon secretion from pancreatic alpha cells, leading to a decrease in hepatic glucose output.

Certified content

Written By

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Amit SharmaClinical Health & Medical Writer| 3 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Linagliptin is available for use via the oral route (tablets).

Age and Dose Restrictions

  • This medicine is meant for use in adults and children above 18 years of age.

Contraindications

  • Linagliptin is CONTRAINDICATED in patients with allergy to metformin, linagliptin, severe renal or hepatic dysfunction, heart problems, and infection.

Other Medications To Avoid With This Medicine

  • The use of certain medications, including heart condition medications (digoxin), diuretics (furosemide), steroids (budesonide), antibiotics (rifampin), anti-epileptic medications (phenytoin, topiramate, lamotrigine), heart-related chest medications (ranolazine), and antidiabetic drugs, including insulin and beta-blockers (such as metoprolol, propranolol, and timolol eye drops for glaucoma), in conjunction with Linagliptin is not recommended. It is crucial to consult with your doctor before using any prescription or over-the-counter medications.

Overdose and Missed Dose

  • Overdose of this medicine can cause lactic acidosis, such as feeling cold or uncomfortable, severe nausea or vomiting, stomach ache, unexplained weight loss, muscular cramps, or rapid breathing. Inform your doctor regarding these effects and follow the advice accordingly.
  • If you forget a dose of this medicine, take it as soon as you remember. But avoid repeating the dose.

Use In Driving And Operating Machinery

  • Linagliptin themselves do not directly impact your ability to drive or operate machinery. However, they may lead to hypoglycemia which can cause dizziness. Taking precautions to prevent low blood sugar while driving or handling machinery is essential.

Use in Pregnancy and Lactation

  • Linagliptin is not recommended in pregnant and breastfeeding women.

Special Dietary & Lifestyle Recommendation

  • Making lifestyle changes, including dietary modifications and regular exercise, is essential when taking Linagliptin to control blood sugar levels properly.
  • After initiating treatment with Linagliptin, it's recommended to have your blood sugar levels reassessed after 15 days and, subsequently, at regular intervals every 3-6 months. This monitoring helps track the progress of the disease and allows for dose adjustments as needed.
  • If hypoglycemia occurs, it's essential to have a quick source of sugar readily available. Carry sugar candies, glucose tablets, or sugary foods and drinks without fat or protein, such as fruit juice, to promptly address low blood sugar episodes.

Frequently asked questions

This medicine may start to work within a few hours, but it may take some time to see the full effects. It's important to continue taking it as your doctor prescribes, even if you start feeling better.

While taking this medicine, be cautious to avoid hypoglycemia (low blood sugar). Avoid taking it if you are allergic to Linagliptin.

Do not stop taking this medicine without consulting your doctor, even if you feel healthy. Abruptly discontinuing this medication can lead to uncontrolled blood sugar levels.

This medicine typically does not affect fertility. However, if you have concerns about fertility and its impact on diabetes management, discuss them with your doctor.

Terms & Conditions


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