Lenalidomide
Uses of Lenalidomide
Lenalidomide's primary use is to manage various types of blood cancers, including multiple myeloma and myelodysplastic syndromes. It belongs to the class of immunomodulatory medicines.
Besides these, Lenalidomide is also used to manage mantle cell lymphoma, especially in patients whose disease has relapsed or progressed after two prior therapies. It's also used as a maintenance therapy following autologous hematopoietic stem cell transplantation (auto-HSCT) in multiple myeloma patients.
Side effects of Lenalidomide
Fatigue
Constipation
Diarrhoea
How Lenalidomide works
Lenalidomide is categorised as an immunomodulatory medication.
It operates by altering your immune system to enhance the function of specific immune cells, primarily T cells and natural killer cells. These cells play a critical role in recognising and attacking cancer cells.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
- Lenalidomide is available in the form (capsules).
Age and Dose Restrictions
- This medicine is typically meant for adults aged 18 and above.
Contraindications
- Lenalidomide is contraindicated in patients who have a known allergy to the medication. It is also contraindicated for patients with severe renal impairment who are not on dialysis.
Other Medications to Avoid
- This medicine may interact with cardiotonic agents (such as digoxin and milrinone), anticoagulants (such as warfarin and heparin) and hormonal contraceptives (like birth control pills).
Overdose and Missed Dose
- An overdose of Lenalidomide may cause severe health complications like neutropenia, deep vein thrombosis, and pulmonary embolism. If you suspect an overdose, seek medical attention immediately.
- If you miss a dose of Lenalidomide, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- Drinking plenty of water may help manage constipation.
- Rest and maintaining adequate hydration may help manage fatigue.
- Maintaining a balanced diet can help manage some gastrointestinal side effects like diarrhoea.
Use in Driving and Operating Machinery
- This medicine may cause dizziness or confusion in some patients. If you experience these side effects, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
- Lenalidomide is not recommended for use during pregnancy due to the risk of severe birth defects.
- It is also not recommended for use while breastfeeding. Consult your doctor before using this medicine if you are pregnant, planning to become pregnant, or breastfeeding.
Caution in Other Conditions
- Lenalidomide should be used with caution in patients with renal impairment, as dose adjustment may be required.
- Patients with a history of thromboembolic events should also exercise caution when using this medicine.
Special Dietary and Lifestyle Recommendations
- Regular blood tests may be necessary while taking this medication to monitor your blood counts and liver function.
Frequently asked questions
Is Lenalidomide considered a steroid?
No, Lenalidomide is not a steroid. It is classified as an immunomodulatory medicine which means it modulates or adjusts the immune system to work against cancer cells.
Can Lenalidomide affect my sleep patterns?
Some general side effects such as fatigue might indirectly influence your sleep. If you have significant changes in your sleep pattern while taking this medication, consult your doctor.
Will taking Lenalidomide impact my fertility?
Lenalidomide can potentially cause harm to an unborn child; therefore, women of childbearing age should use effective contraception while on this medication. It is unclear whether it directly affects fertility, but it is recommended to discuss your concerns with your doctor.
Can Lenalidomide affect mood or mental health?
Any changes in mood, behaviour, or mental health while taking this medicine should be reported to a doctor.
How long does it take for Lenalidomide to start working?
The time taken by Lenalidomide to show its effect can vary based on the condition being managed and the individual's body response. You should start noticing improvements in your symptoms as directed by your doctor.
Do I need a prescription for Lenalidomide, or can I buy it over the counter?
Lenalidomide requires a prescription from a registered doctor and cannot be bought over the counter. This is due to its potential side effects and the need for close monitoring by a doctor while you are on this medication.
Is it okay to take Lenalidomide if I am lactose intolerant?
Lenalidomide capsules do not contain lactose. If you have any concerns about the ingredients in your medication, it is best to discuss this with your doctor or pharmacist.
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