Ledipasvir + Sofosbuvir
Uses of Ledipasvir + Sofosbuvir
Ledipasvir + Sofosbuvir is primarily used for managing chronic hepatitis C virus (HCV) infection. It belongs to the group of antiviral medicines.
The medicine is also prescribed to manage HCV genotype 1 infection in patients with advanced liver disease, including decompensated cirrhosis.
Side effects of Ledipasvir + Sofosbuvir
Fatigue
Headache
Nausea
Insomnia
Diarrhoea
How Ledipasvir + Sofosbuvir works
Ledipasvir is classified as an HCV NS5A inhibitor. Simply put, it disrupts the workings of a protein called NS5A in the hepatitis C virus, which is crucial for the virus to multiply and survive.
Sofosbuvir is known as a nucleotide analogue NS5B polymerase inhibitor. It mimics the building blocks of the virus's genetic material and gets inserted into it.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Ledipasvir + Sofosbuvir can be taken orally (tablet and oral pellet).
Age and Dose Restrictions
This medicine is suitable for adults and children above 12 years of age or weighing at least 35 kg.
Contraindications
Ledipasvir + Sofosbuvir is contraindicated in patients with severe renal impairment or end-stage renal disease requiring dialysis.
Other Medications to Avoid
Ledipasvir + Sofosbuvir may interact with antibiotics (such as rifampin) and herbal medicines (St. John's wort).
Overdose and Missed Dose
If an overdose of Ledipasvir + Sofosbuvir is suspected, seek immediate medical attention.
In case of a missed dose, take it as soon as you remember on the same day. However, do not double the dose if it is near the time for your next dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Stay hydrated to manage symptoms such as fatigue and headaches.
Rest and relax to help manage fatigue.
Use in Driving and Operating Machinery
Ledipasvir + Sofosbuvir may cause dizziness or weakness in some patients. If you experience these side effects, avoid driving or operating heavy machinery until you feel well enough.
Use in Pregnancy and Lactation
It is always advised to consult your doctor before using this medicine during pregnancy or breastfeeding.
Caution in Other Conditions
Patients with decompensated cirrhosis should exercise caution when taking Ledipasvir + Sofosbuvir.
Special Dietary and Lifestyle Recommendations
Regular check-ups with your doctor are recommended to monitor the progress of the disease and the effectiveness of the medication.
Frequently asked questions
Can Ledipasvir + Sofosbuvir cause any changes in my mood?
No, there are no commonly reported effects of Ledipasvir + Sofosbuvir on mood. However, individual reactions to medicine can vary, and if you notice any unusual changes, consult your doctor.
Is it safe for a vegetarian or vegan to take Ledipasvir + Sofosbuvir?
Yes, Ledipasvir + Sofosbuvir is safe for vegetarians and vegans. This medicine does not contain any animal-derived components.
Is there a risk of addiction or dependence with Ledipasvir + Sofosbuvir?
No, there is no risk of addiction or dependence with Ledipasvir + Sofosbuvir.
Can I take natural alternatives while taking Ledipasvir + Sofosbuvir?
It is important to discuss this with your doctor before starting any new medications or supplements, as they may interact with Ledipasvir + Sofosbuvir.
Is Ledipasvir + Sofosbuvir a long-term medication?
Yes, the duration of treatment with Ledipasvir + Sofosbuvir can range from 12 to 24 weeks, depending on the patient's liver disease status and prior HCV treatment history.
Is stopping Ledipasvir + Sofosbuvir abruptly harmful?
Yes, abruptly stopping any antiviral medication including Ledipasvir + Sofosbuvir can lead to viral resistance or disease relapse. Always follow your doctor’s advice regarding the duration of treatment.
Does Ledipasvir + Sofosbuvir cause weight gain?
There is no established link between Ledipasvir + Sofosbuvir and weight gain. However, different individuals may experience different side effects. If you notice any sudden, unexplained weight gain, please consult your doctor.
Ledipasvir + Sofosbuvir in other salts
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