Lapatinib
Uses of Lapatinib
Lapatinib is used in managing advanced or metastatic HER2-positive breast cancer that has not responded adequately to other treatments. It belongs to the tyrosine kinase inhibitors group of medicines.
Lapatinib is also used in combination with another medication called capecitabine.
Side effects of Lapatinib
Diarrhoea
Nausea
Rash
Fatigue
How Lapatinib works
Lapatinib is a member of the tyrosine kinase inhibitors therapeutic category.
It works by specifically blocking the action of two proteins, EGFR and HER2, which are often found on certain cancer cells. These proteins generally send signals that tell the cells to divide and grow. By blocking these signals, Lapatinib effectively slows down or even stops the growth and spread of the cancer cells.
This mechanism makes Lapatinib an effective medication used in managing certain types of advanced or metastatic breast cancer.
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Expert Advice
Dosage forms available
Lapatinib is available as oral tablets.
Age and dose restrictions
This medication is meant for adult use only.
Contraindications
This medicine is contraindicated in patients with known hypersensitivity or allergies to Lapatinib. Patients with severe liver disease should also avoid using this medicine due to its potential to cause further hepatic damage.
Other medications to avoid with this medicine
Lapatinib may interact with strong inhibitors of CYP3A4 enzymes (such as ketoconazole, itraconazole, and clarithromycin) and strong inducers of CYP3A4 (like rifampin, phenytoin, St. John's wort).
Overdose and missed dose
If an overdose of Lapatinib occurs, it could lead to severe symptoms such as chest pain, shortness of breath, or fainting. Should you suspect an overdose, seek immediate medical assistance.
In the event of a missed dose, take the medication as soon as you remember. However, if it is closer to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take double doses to make up for the missed one.
Management of side effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.
Maintaining good hydration by drinking plenty of fluids to manage common side effects like diarrhoea.
For skin reactions such as rash, use over-the-counter topical creams or ointments that relieve itching and irritation.
In case of nausea, try eating smaller, more frequent meals instead of large ones.
Use in driving and operating machinery
Lapatinib may cause fatigue and dizziness, which could affect your ability to drive or operate heavy machinery. If you experience these side effects, avoid such activities until these symptoms are managed.
Use in pregnancy and lactation
Due to potential risks to the foetus, Lapatinib should not be used during pregnancy. Women of childbearing age should use effective contraception while on this medication.
Breastfeeding is not recommended while taking Lapatinib.
Caution in other conditions
Patients with a history of heart disease should exercise caution when taking Lapatinib as it can affect heart function. Regular monitoring of cardiac health is recommended in these cases.
Special dietary and lifestyle recommendation
It is advisable to maintain a balanced diet while on Lapatinib therapy to help manage potential side effects like loss of appetite or nausea.
Regular moderate physical activity can also contribute to overall well-being and help manage fatigue associated with the disease and its treatment.
Avoid consuming grapefruit or grapefruit juice while on Lapatinib therapy as it may interact with the medication and increase its levels in the body.
Frequently asked questions
Is Lapatinib a steroid?
No, Lapatinib is not a steroid. It is a tyrosine kinase inhibitor, a type of medicine that blocks specific proteins involved in cancer cell growth and division.
Can Lapatinib harm the foetus if taken during pregnancy?
Yes, Lapatinib can cause harm to an unborn baby and should not be used during pregnancy. Women of childbearing potential must use effective contraception while taking this medicine.
Does Lapatinib affect menstrual cycle?
No, Lapatinib does not affect the menstrual cycle. It is best to consult your doctor if you notice any imbalance.
Is Lapatinib taken with food or on an empty stomach?
Lapatinib should be taken on an empty stomach, at least 1 hour before or after a meal. Always consult your doctor first.
Is there a risk of addiction or dependency on Lapatinib?
No, there is no evidence to suggest that there is a risk of addiction or dependency on Lapatinib.
Can I take herbal supplements while on Lapatinib?
Some herbal supplements might interact with Lapatinib, such as St. John's Wort, which can reduce the levels of the medication in the body. It is important to inform your doctor about all supplements you are taking to avoid any potential interactions.
Will the doctor monitor my health while I’m taking Lapatinib?
Yes, while you are taking Lapatinib, your doctor will order periodic tests to monitor your heart function, liver enzymes, and electrolyte levels. Any new symptoms should be reported promptly.
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