Lamivudine + Tenofovir Disoproxil Fumarate
Uses of Lamivudine + Tenofovir Disoproxil Fumarate
Lamivudine + Tenofovir Disoproxil Fumarate is primarily used to manage HIV-1 infection and chronic hepatitis B virus (HBV) infection. It falls under the classification of antiretroviral agents.
Side effects of Lamivudine + Tenofovir Disoproxil Fumarate
Headache
Pain
Depression
Diarrhoea
Rash
How Lamivudine + Tenofovir Disoproxil Fumarate works
Lamivudine + Tenofovir Disoproxil Fumarate is an antiretroviral combination.
Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI). It mimics cytidine, a component of DNA. When the HIV virus tries to multiply, lamivudine is incorporated into its DNA. This stops the DNA chain from growing further, preventing the virus from multiplying.
Tenofovir disoproxil fumarate is also an NRTI. It imitates adenosine 5'-monophosphate, another component of DNA. Similar to lamivudine, it gets incorporated into the HIV virus’s DNA when it tries to replicate. This halts the DNA chain from extending, inhibiting the virus from multiplying. Together, these two active ingredients work in harmony to effectively inhibit the multiplication of the HIV virus, assisting in the management of HIV-1 infection.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Lamivudine + Tenofovir Disoproxil Fumarate is available as oral tablets for use.
Age and Dose Restrictions
Lamivudine + Tenofovir Disoproxil Fumarate is intended for adults and also for children of age above 12 years and who are at least 35 kilograms in weight.
Contraindications
This combination is contraindicated for individuals who have previously shown hypersensitivity to any of its components.
Other Medications to Avoid
Lamivudine + Tenofovir Disoproxil Fumarate may interact with several medications, including antivirals (such as adefovir or cidofovir), nephrotoxic agents (like aminoglycosides), nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen), and certain antibiotics (like vancomycin).
Overdose and Missed Dose
If an individual overdoses on Lamivudine + Tenofovir Disoproxil Fumarate, they should be closely monitored for any signs of toxicity. Standard supportive treatment should be applied as necessary.
If a dose of this medicine is missed, take it as soon as it is remembered. However, if it is nearing the time for the next dose, skip the missed dose and continue with the regular dosing schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage some common side effects such as diarrhoea and headaches.
Use in Driving and Operating Machinery
Lamivudine + Tenofovir Disoproxil Fumarate does not usually affect your ability to drive or operate heavy machinery. However, if you feel dizzy or sleepy after taking the medicine, it is advisable not to drive or operate heavy machinery.
Use in Pregnancy and Lactation
Consult your doctor before using Lamivudine + Tenofovir Disoproxil Fumarate during pregnancy and breastfeeding.
Caution in Other Conditions
For patients with severe renal impairment, this medicine is not recommended.
No dose adjustment is required for patients with hepatic impairment.
Special Dietary and Lifestyle Recommendations
Adequate sleep and stress management can also improve overall health and wellbeing.
Frequently asked questions
Is Lamivudine + Tenofovir Disoproxil Fumarate a steroid?
No, Lamivudine + Tenofovir Disoproxil Fumarate is not a steroid. It is a combination of two antiretroviral medications used to manage HIV-1 infection and chronic hepatitis B.
Does the Lamivudine + Tenofovir Disoproxil Fumarate have any effect on sleep?
Lamivudine + Tenofovir Disoproxil Fumarate does not generally have any direct effects on sleep. However, like all medicines, individual reactions may vary and if you are experiencing trouble sleeping, consult your doctor.
Will Lamivudine + Tenofovir Disoproxil Fumarate affect fertility?
Lamivudine + Tenofovir Disoproxil Fumarate is not associated with affecting fertility in men or women. However, if you are planning to conceive, discuss this with your doctor.
How much time does Lamivudine + Tenofovir Disoproxil Fumarate take to work?
The duration of action varies for each individual and depends on the severity of the disease condition. It is recommended to take the medication regularly as per the doctor’s advice for best results.
What is the best time to take Lamivudine + Tenofovir Disoproxil Fumarate?
This medicine should be taken as prescribed by the doctor. It can be taken at any time but it is best to maintain consistency in timing.
Is Lamivudine + Tenofovir Disoproxil Fumarate available over the counter, or do I need a prescription?
Lamivudine + Tenofovir Disoproxil Fumarate is a prescription medicine and is not available over the counter.
Is it safe to take Lamivudine + Tenofovir Disoproxil Fumarate daily?
Yes, it is safe to take this medication daily as prescribed by your doctor. It is important to take the medication consistently for its full benefit.
Lamivudine + Tenofovir Disoproxil Fumarate in other salts
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