L-methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate
Uses of L-methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate
L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate is predominantly used to manage vitamin B deficiencies. It belongs to the group of vitamin supplements.
Additionally, it is used to manage elevated homocysteine levels (hyperhomocysteinemia), anaemia due to vitamin B deficiencies, peripheral neuropathy (particularly in diabetic patients), cognitive disorders such as age-related cognitive decline and mild cognitive impairment, mood disorders including depression and anxiety. It is also recommended during pregnancy to support fetal neural tube development and prevent congenital anomalies.
Side effects of L-methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate
Gastrointestinal discomfort
Nausea
Vomiting
Headache
Insomnia
How L-methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate works
L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate is a nutritional supplement.
L-Methylfolate Calcium is the active form of Vitamin B9. It aids in the synthesis of DNA, RNA, and amino acids, facilitates blood cell production, and helps convert the harmful amino acid homocysteine into methionine, thus reducing the risk of heart diseases.
Methylcobalamin is the active form of Vitamin B12. It helps in the proper functioning of the brain and nervous system, contributes to the production of myelin (a protective layer around nerve fibres), and aids in the synthesis of neurotransmitters such as serotonin and dopamine.
Pyridoxal 5 Phosphate is the active form of Vitamin B6. It functions as a coenzyme in numerous reactions, aids in the metabolism of proteins, carbohydrates, and fats, supports neurotransmitter synthesis, and helps regulate homocysteine levels.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate is available for oral use in the form of tablets and capsules.
Age and Dose Restrictions
This medicine is meant for adults and children over the age of 12.
Contraindications
This medicine is contraindicated in patients with an allergy to any of the active components.
It should not be used by those with an existing accumulation of methylcobalamin in the body.
Other Medications to Avoid
This combination may interact with anticonvulsants (such as phenytoin and valproate), proton pump inhibitors (like omeprazole and pantoprazole), and certain antibiotics (such as chloramphenicol and metronidazole).
Overdose and Missed Dose
An overdose may lead to symptoms like nausea, headache, and numbness. If these occur, it is important to seek medical advice from a doctor.
If you miss a dose of this medicine, simply take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage nausea, try taking the medicine with food or a glass of water.
For headaches, ensure adequate hydration and rest.
Use in Driving and Operating Machinery
There is no evidence suggesting that L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate impacts the ability to drive or operate machinery. However, if you experience dizziness or drowsiness, it is advisable to avoid such activities until these effects subside.
Use in Pregnancy and Lactation
The use of L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate during pregnancy and lactation should only be considered when prescribed by a doctor. It is important to discuss all potential risks and benefits with your doctor before starting this medication.
Caution in Other Conditions
Caution is advised for patients with renal or liver conditions when taking this medication.
Those with a history of seizure disorders should consult their doctor due to potential interactions with anticonvulsant medications.
Special Dietary and Lifestyle Recommendations
Include foods rich in vitamin B6, B12, and folate in your diet such as leafy green vegetables, fruits, nuts, beans, poultry, fish, and fortified cereals.
Maintain hydration levels by drinking sufficient water throughout the day to help manage potential side effects like headaches.
Regular physical activity can help reduce stress and improve overall health which complements the treatment of mood disorders.
Implement stress reduction techniques such as yoga or meditation to aid in managing mood disorders or cognitive functions that this combination aims to support.
Frequently asked questions
What is the main purpose of taking L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate?
L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate is mainly used to manage vitamin B deficiencies and elevated homocysteine levels. It is also beneficial in managing conditions like peripheral neuropathy, cognitive disorders, mood disorders, and in supporting foetal neural tube development during pregnancy.
Could L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate cause drowsiness?
L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate is not commonly associated with drowsiness. However, individual reactions may vary. If you experience drowsiness, it's best to consult your doctor for advice.
Can I take L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate without food?
The absorption of these vitamins is not specifically dependent on food intake. Hence, they can be taken with or without food. However, if stomach upset occurs when taken on an empty stomach, it may be beneficial to take it with or after meals.
Can vegetarians and vegans use L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate?
Yes, vegetarians and vegans can use this combination to manage vitamin B deficiencies and other indicated conditions. However, as the origin may vary according to the manufacturer's formulation, it's always advisable to check the product label or consult your doctor for clarity.
Can I continue my regular exercise while taking L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate?
Yes, regular exercise can be continued while taking L-Methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate unless your doctor advises otherwise.
How does this combination work?
L-Methylfolate is the active form of folate, which supports brain function and mood. Methylcobalamin is an active form of Vitamin B12 that promotes nerve health, and Pyridoxal 5 Phosphate is the active form of Vitamin B6, which supports metabolism and nerve function.
Are there any natural food sources of L-Methylfolate Calcium, Methylcobalamin and Pyridoxal 5 Phosphate?
Yes, these vitamins are found naturally in many foods. Folate is abundant in leafy green vegetables, beans, peas and lentils. Vitamin B12 is mainly found in animal products such as fish, meat, poultry, eggs, milk, and milk products. Vitamin B6 is found in a wide variety of foods including meat, cereals, bananas, avocados, and potatoes.
L-methylfolate Calcium + Methylcobalamin + Pyridoxal 5 Phosphate in other salts
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