Itraconazole + Terbinafine
Uses of Itraconazole + Terbinafine
The primary use of Itraconazole + Terbinafine is to manage a wide range of fungal infections, including onychomycosis, tinea corporis, tinea pedis, tinea cruris, aspergillosis, blastomycosis, and histoplasmosis. This medication belongs to the classes of azole antifungals and allylamine antifungals.
Side effects of Itraconazole + Terbinafine
Nausea
Headache
Diarrhoea
Abdominal pain
Rash
How Itraconazole + Terbinafine works
Itraconazole belongs to the group of antifungal medicines called azoles. It works by stopping the production of ergosterol, a substance that is a key component of fungal cell membranes. This disruption in production leads to the death of the fungal cells.
Terbinafine is an allylamine type of antifungal medicine. It also targets the production of ergosterol but does so by inhibiting the enzyme squalene epoxidase, which is essential in its synthesis. Working together in this combination, both Itraconazole and Terbinafine provide a strong and effective defence against a broad range of fungal infections.
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Written By
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Reviewed By
Doctor of Medicine
Expert Advice
Dosage Forms Available
Itraconazole + Terbinafine can be taken orally (tablets) or applied topically (cream).
Age and Dose Restrictions
This combination medication is meant for adults. It may also be used in children above 12 years of age under the supervision of a doctor.
Contraindications
This combination medication should not be used by individuals with known hypersensitivity to either Itraconazole or Terbinafine.
Other Medications to Avoid
This combination may interact with antiarrhythmics (such as quinidine and dofetilide), anticoagulants (such as warfarin), antidepressants (like Citalopram and Escitalopram), antidiabetics (like glipizide and glyburide) and calcium channel blockers (like felodipine and nisoldipine).
Overdose and Missed Dose
An overdose of this medication may cause symptoms such as nausea, vomiting, abdominal pain, diarrhoea, headache, and dizziness. If you suspect an overdose, seek immediate medical attention.
If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For managing nausea, try taking this medication with or after a meal.
You can manage diarrhoea by drinking plenty of fluids to prevent dehydration.
Use in Driving and Operating Machinery
This medication may cause dizziness or fatigue. If you experience these side effects, avoid driving or operating heavy machinery until you feel well enough to do so.
Use in Pregnancy and Lactation
The safety of this combination during pregnancy and lactation has not been established. It is advised to consult your doctor before using this medicine while pregnant or breastfeeding.
Caution in Other Conditions
Patients with pre-existing liver conditions should exercise caution when taking this medicine, as both Itraconazole and Terbinafine can potentially cause liver problems.
Caution should also be exercised in patients with pre-existing cardiac conditions due to the possible cardiac effects of Itraconazole.
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet to support your overall health. This can help your body's immune system fight off fungal infections.
Good personal hygiene practices can help prevent the spread and recurrence of fungal infections.
Frequently asked questions
Is Itraconazole + Terbinafine available over the counter, or do I need a prescription?
No, Itraconazole + Terbinafine is not available over the counter and you need a prescription from your doctor to access this medicine.
Is Itraconazole + Terbinafine a steroid?
No, Itraconazole + Terbinafine is not a steroid. It comprises two antifungal components: Itraconazole, an azole antifungal, and Terbinafine, an allylamine antifungal.
How much time does Itraconazole + Terbinafine take to work?
The time it takes for Itraconazole + Terbinafine to work depends greatly on the type and severity of the fungal infection. Noticeable improvement may occur within a few weeks, but complete resolution can take several months.
Will Itraconazole + Terbinafine affect my mood or hormonal balance?
Itraconazole + Terbinafine is not associated with effects on mood or hormonal balance. This antifungal medication is primarily used to treat fungal infections and does not typically impact mood or hormones.
Can Itraconazole + Terbinafine cause dependency or addiction?
No, Itraconazole + Terbinafine does not cause dependency or addiction as it is an antifungal medication and not a narcotic or psychoactive substance.
Does Itraconazole + Terbinafine have any effect on sleep?
Itraconazole + Terbinafine is not associated with any direct effects on sleep. This antifungal medication is used to treat fungal infections and has no known impact on sleep patterns.
Will Itraconazole + Terbinafine affect fertility?
Itraconazole + Terbinafine is not associated with effects on fertility. This medication is used to treat fungal infections and does not have known impacts on reproductive health.
Itraconazole + Terbinafine in other salts
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