Isoxsuprine
Uses of Isoxsuprine
Isoxsuprine is primarily used to manage peripheral vascular diseases such as Raynaud's phenomenon (some areas of the body feel numb and cool in certain circumstances), Buerger's disease (recurring progressive inflammation and thrombosis of small and medium arteries and veins of the hands and feet), and peripheral artery disease. It's a vasodilator and beta-adrenergic agonist.
It is also used to improve blood flow to the brain in conditions associated with cerebral vascular insufficiency, such as cerebral arteriosclerosis and stroke. Additionally, it is used off-label as a tocolytic agent to prevent and treat early labour in pregnant women.
Side effects of Isoxsuprine
Headache
Vomiting
Flushing and sweating
Chest pain or palpitations
Tremors or nervousness
How Isoxsuprine works
Isoxsuprine is a vasodilator and beta-adrenergic agonist.
It stimulates beta-2 receptors in the smooth muscles of blood vessels and the uterus, relaxing and dilating them. This results in increased blood flow and circulation in blood vessels, helping manage conditions related to poor blood circulation. In the uterus, it reduces the frequency and intensity of contractions, helping prevent early labour.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
- Isoxsuprine is available in the form of tablets and sustained-release capsules for oral administration, and also as intravenous injections.
Age and Dose Restrictions
- Isoxsuprine is prescribed for adults. It is not safe for use in children, unless under close monitoring by a doctor.
- Your dose will be determined by your doctor, depending on your underlying condition and response to the medicine. Follow your doctor's instructions.
Contraindications
- Isoxsuprine should not be used in patients with known hypersensitivity to it or its components, severe coronary artery disease, heart attack, severe tachycardia (rapid heartbeat) or arrhythmias (irregular heartbeat), and active bleeding or haemorrhage.
Other Medications to Avoid
- Isoxsuprine may interact with antihypertensives (like irbesartan and spironolactone) and monoamine oxidase inhibitors (like Linezolid and Procarbazine).
- Consult your doctor before starting any prescription or over-the-counter medication.
Overdose and Missed Dose
- If you take too much Isoxsuprine, you may experience common side effects such as dizziness and nausea. If these persist, consult your doctor.
- If you forget to take a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and resume your doctor-prescribed regular dosing regime. Do not double-dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve upon discontinuation of the medicine. However, if you experience severe side effects or worsening symptoms, consult your doctor.
- Rising slowly from a sitting or lying position helps manage dizziness.
- Staying well-hydrated and maintaining a cool environment helps minimise sweating.
Use in Driving and Operating Machinery
- Isoxsuprine may affect your ability to drive or operate heavy machinery due to potential side effects. Avoid these activities if you experience these effects.
Use in Pregnancy and Lactation
- Isoxsuprine is used off-label to prevent and treat early labour. However, its use during pregnancy should be under medical supervision as it can affect the foetus and newborn.
- If breastfeeding, consult your doctor before starting this medication.
Caution in Other Conditions
- If you have cardiovascular diseases, take Isoxsuprine with caution.
- Exercise caution if you have hyperthyroidism (overactive thyroid), glaucoma, or bleeding disorders.
Special Dietary and Lifestyle Recommendations
- Staying well-hydrated can help manage side effects like flushing.
- Maintaining a cool environment can help minimise side effects.
Regular physical activity, such as walking or yoga, can improve overall health, helping the medicine manage conditions related to poor blood circulation.
Frequently asked questions
Can Isoxsuprine be taken before or after meals?
Yes. However, taking it with food can help reduce gastrointestinal side effects such as nausea.
How long does it take for Isoxsuprine to start working?
The onset of its action may vary depending on the formulation and route of administration. Oral tablets start working within 30 minutes to an hour, while intravenous injections may have a more rapid effect.
Can I suddenly stop taking Isoxsuprine?
It is recommended to lessen Isoxsuprine gradually under a doctor's guidance. Sudden discontinuation may lead to rebound symptoms or worsening of the underlying condition.
Can I drink alcohol while taking Isoxsuprine?
No, as it can enhance some of the salt's side effects. Consult your doctor for more information.
Can Isoxsuprine interact with other medications?
Isoxsuprine can interact with medications such as beta-blockers (like atenolol and timolol) and ergot alkaloids (like cafergot and migranal). Inform your doctor about all current medications to avoid potential interactions.
What happens if I have an allergic reaction to Isoxsuprine?
If you have an allergic reaction to Isoxsuprine, such as rash, itching, difficulty breathing or swelling of the face, lips, tongue or throat, seek immediate medical attention.
How should I store Isoxsuprine?
Store Isoxsuprine at room temperature, away from heat, light, and moisture, and out of reach of children.
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