Hydralazine + Isosorbide Dinitrate
Uses of Hydralazine + Isosorbide Dinitrate
The primary use of Hydralazine + Isosorbide Dinitrate is to manage heart failure in black patients, especially those diagnosed with New York Heart Association (NYHA) class III or IV heart failure. It belongs to the class of vasodilator medicines.
Side effects of Hydralazine + Isosorbide Dinitrate
Headache
Nausea and vomiting
Increased heart rate
Dizziness
Fatigue
How Hydralazine + Isosorbide Dinitrate works
Hydralazine is a vasodilator, which means it relaxes and widens your blood vessels. This makes it easier for blood to flow through them and reduces the workload on your heart.
Isosorbide Dinitrate is a nitrate, and it also works by widening blood vessels. This action increases the supply of blood to your heart, further reducing its workload.
Together, these medicines work in harmony to enhance heart function by easing the flow of blood and decreasing the amount of work your heart has to do.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Hydralazine + Isosorbide Dinitrate is available as oral tablets for easy administration.
Age and Dose Restrictions
This medicine is intended for use in adults only. It is not recommended for use in children or adolescents below 18 years of age.
Contraindications
Hydralazine + Isosorbide Dinitrate is contraindicated in patients with known hypersensitivity to either component of the medication.
It is also contraindicated in patients with severe anaemia or acute myocardial infarction.
Other Medications to Avoid
Hydralazine + Isosorbide Dinitrate may interact with other vasodilators (such as sildenafil), other nitrates (such as nitroglycerin), and medications used to treat high blood pressure (such as amlodipine).
Overdose and Missed Dose
Overdose of Hydralazine + Isosorbide Dinitrate can lead to symptoms such as severe headache, dizziness, or rapid heartbeat. Patients should seek immediate medical attention if they suspect an overdose.
If a dose is missed, it should be taken as soon as remembered. However, if it is near the time for the next dose, skip the missed dose and continue with the normal dosing schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water might help in managing nausea and vomiting associated with this medicine.
Try to stand up slowly from a sitting or lying position to avoid dizziness.
Use in Driving and Operating Machinery
Hydralazine + Isosorbide Dinitrate may cause dizziness. Patients should avoid driving or operating heavy machinery if they experience this side effect.
Use in Pregnancy and Lactation
It is advised to consult a doctor before using Hydralazine + Isosorbide Dinitrate during pregnancy or while breastfeeding.
Caution in Other Conditions
Patients with liver or kidney disease or those with angina (chest pain) should exercise caution when using Hydralazine + Isosorbide Dinitrate.
Special Dietary and Lifestyle Recommendations
Maintain a low-sodium diet to help manage heart failure symptoms.
Refrain from smoking and reduce alcohol consumption, as these habits can worsen heart conditions.
Frequently asked questions
Is Hydralazine + Isosorbide Dinitrate a steroid?
No, Hydralazine + Isosorbide Dinitrate is not a steroid. It is a combination medication used primarily to manage heart failure..
Can Hydralazine + Isosorbide Dinitrate affect my sleep patterns?
Yes, Hydralazine + Isosorbide Dinitrate can potentially affect sleep patterns. They might cause side effects like dizziness or headaches that could disrupt sleep. If you experience sleep issues, discuss them with your doctor.
Will taking Hydralazine + Isosorbide Dinitrate have any impact on fertility?
Hydralazine + Isosorbide Dinitrate is not typically associated with changes in fertility. However, if you have specific concerns, it's best to consult a doctor.
Is it safe to take Hydralazine + Isosorbide Dinitrate every day?
Hydralazine + Isosorbide Dinitrate can be taken daily if prescribed by your doctor. It's important to follow your doctor's instructions and attend regular check-ups to monitor for any side effects or adjustments needed.
How long does it take for Hydralazine + Isosorbide Dinitrate to start working?
The time it takes for Hydralazine + Isosorbide Dinitrate to show its effect may vary from person to person. Some people may notice improvements in their symptoms within a few days, while for others it may take a few weeks.
Do I need a prescription to buy Hydralazine + Isosorbide Dinitrate?
Yes, Hydralazine + Isosorbide Dinitrate is not available over the counter and requires a prescription from a doctor.
What is the best time to take Hydralazine + Isosorbide Dinitrate?
The best time to take Hydralazine + Isosorbide Dinitrate is as prescribed by your doctor. The medicine is usually taken three times daily, with the dose adjusted based on patient tolerance and response.
Hydralazine + Isosorbide Dinitrate in other salts
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