Hyaluronidase
Uses of Hyaluronidase
Hyaluronidase is primarily used to enhance the absorption and dispersion of other injected medicines. It belongs to the class of enzymes known as hyaluronidases.
Secondary uses of this medication include improving the absorption of subcutaneous fluids, managing medicine extravasation, enhancing contrast media absorption in subcutaneous urography, and various off-label uses such as dissolving hyaluronic acid fillers and managing skin necrosis from filler injections.
Side effects of Hyaluronidase
Pain at the injection site
Redness at the injection site
Swelling at the injection site
Headache
Nausea and vomiting
How Hyaluronidase works
Hyaluronidase is an enzyme enhancer.
It works by breaking down hyaluronic acid, a natural substance in the body that can obstruct the absorption of other medications. This is achieved by cleaving the beta 1-4 linkages between its component sugars. The depolymerisation or breakdown of hyaluronic acid forms small channels between cells, thereby allowing other injected medicines to permeate and spread more easily.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Hyaluronidase is available for use via the subcutaneous route in the form of an injectable solution.
Age and Dose Restrictions
Hyaluronidase is intended for use in adults. It is typically not recommended for children under 2 years old. Dosage should be determined by a doctor based on the condition being treated.
Contraindications
Hyaluronidase is contraindicated in patients with known allergies to hyaluronidase or any component of the formulation.
This medicine is also contraindicated in patients with active infection or inflammation at the injection site.
Severe renal impairment
Other Medications to Avoid
Hyaluronidase may interact with diuretics (such as furosemide), benzodiazepines (such as diazepam and lorazepam), anticoagulants (such as warfarin), thrombolytic agents (such as streptokinase), NSAIDs (such as ibuprofen) and live virus vaccines (like influenza vaccine).
Overdose and Missed Dose
An overdose of this medication may cause adverse reactions such as allergic reactions or severe injection site reactions. If you observe these symptoms, inform your doctor and follow the advice accordingly.
If you forget to administer this medicine, consult your doctor immediately for further guidance. Do not double dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.
Resting in a dark, quiet room may help if you experience dizziness.
Applying a cold compress to the injection site can help manage local reactions such as redness and swelling.
Use in Driving and Operating Machinery
Hyaluronidase may cause side effects like dizziness. Avoid driving or operating heavy machinery if you feel dizzy or unsteady after administration of this medicine.
Use in Pregnancy and Lactation
It should only be used if the benefits outweigh the risks. Consult your doctor before using this medicine in pregnancy and breastfeeding.
Caution in Other Conditions
Patients with known allergies should exercise caution when using Hyaluronidase as it may trigger allergic reactions.
Caution is advised in patients with bleeding disorders or taking anticoagulant medications, as Hyaluronidase may increase the risk of bleeding.
Special Dietary and Lifestyle Recommendations
Maintain good hydration by drinking plenty of fluids as it can aid in the dispersal of injected medicines.
Avoid exposure to allergens if you have known allergies, as this medication can trigger allergic reactions.
Frequently asked questions
Is Hyaluronidase a steroid?
No, Hyaluronidase is not a steroid. It is an enzyme that enhances the absorption and dispersion of other injected medicines by breaking down hyaluronic acid in the body.
Does Hyaluronidase have any effect on sleep?
Hyaluronidase is an enzyme used to break down hyaluronic acid in various medical and cosmetic treatments. It is not commonly associated with affecting sleep. If you experience any sleep disturbances after receiving hyaluronidase, it's best to consult your doctor.
Will Hyaluronidase affect fertility?
Hyaluronidase is not typically associated with affecting fertility. It is used to enhance the absorption and dispersion of other substances in the body and does not generally have an impact on reproductive health. If you have specific concerns, it's best to discuss them with your healthcare provider.
Is it safe to administer Hyaluronidase daily?
Hyaluronidase is typically administered by a healthcare professional as part of a larger medical procedure and is not administered daily. Please follow your doctor’s instructions for use.
How much time does Hyaluronidase take to work?
Hyaluronidase starts working shortly after administration to break down hyaluronic acid and improve medication absorption, but the exact timing can vary depending on the individual and the specific medical procedure.
What is the best time to take Hyaluronidase?
Hyaluronidase is not typically taken on a regular schedule but is administered by a healthcare professional as needed for certain medical procedures. Please consult your doctor for more information.
Is Hyaluronidase available over the counter, or do I need a prescription?
Hyaluronidase is a prescription medication and is not available over the counter. It must be administered by a healthcare professional.
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