Finerenone
Uses of Finerenone
Finerenone is primarily used to manage chronic kidney disease (CKD) in patients with type 2 diabetes (T2D). It belongs to the class of medicines known as non-steroidal mineralocorticoid receptor antagonists.
Research is also underway to explore its potential in reducing the risk of kidney failure, cardiovascular events, and cardiovascular mortality in adults with CKD associated with T2D.
Side effects of Finerenone
High blood potassium levels (Hyperkalemia)
Low sodium levels (Hyponatremia)
Low blood pressure (Hypotension)
High uric acid levels (Hyperuricemia)
Itching (Pruritus)
How Finerenone works
Finerenone is a non-steroidal mineralocorticoid receptor antagonist (MRA).
It works by selectively blocking the mineralocorticoid receptors (MRs) in the body. These receptors, when activated by hormones like aldosterone and cortisol, can lead to inflammation and fibrosis in the heart and kidneys, conditions linked to chronic kidney disease (CKD) and type 2 diabetes (T2D). By inhibiting the MRs, Finerenone reduces these harmful effects, helping to manage inflammation, fibrosis and subsequent damage in the heart and kidneys. This mechanism is thus valuable in managing CKD in T2D patients.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Finerenone is available for use via oral route in the form of tablets.
Age and Dose Restrictions
This medicine is meant for adults. Specific dosage restrictions will depend upon the individual, their condition, and their doctor's advice.
Contraindications
Finerenone is contraindicated in patients with known allergies to the active ingredient.
This medicine is contraindicated in patients with Addison's disease (a disorder of the adrenal glands) and high blood potassium levels (hyperkalemia).
Other Medications to Avoid
Finerenone may interact with CYP3A4 inhibitors (such as ketoconazole, itraconazole), CYP3A4 inducers (like rifampin, carbamazepine), and potassium-sparing diuretics (such as spironolactone). These interactions can influence the medicine's metabolism and increase the risk of hyperkalemia or other side effects.
Overdose and Missed Dose
An overdose of Finerenone may lead to severe hyperkalemia (high blood potassium levels). If you suspect an overdose, inform your doctor immediately and follow the advice accordingly.
If you forget to take your dose of Finerenone, take it as soon as you remember. But avoid doubling up on the dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor. To manage potential side effects:
If you experience hyperkalemia (high blood potassium levels), drink plenty of water to help flush out excess potassium from your body.
If hypotension (low blood pressure) occurs, try sitting or lying down until the symptoms pass.
Use in Driving and Operating Machinery
Finerenone does not affect your ability to drive or operate heavy machinery. However, if you feel dizzy after taking this medicine, avoid driving or operating machinery until you feel well again.
Use in Pregnancy and Lactation
It is advised to consult your doctor before using Finerenone during pregnancy and breastfeeding.
Caution in Other Conditions
Patients with liver disease should exercise caution when taking Finerenone.
Caution should also be exercised in patients with high blood potassium levels (hyperkalemia).
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet that is low in potassium to help manage high blood potassium levels.
Regular check-ups are necessary to monitor your kidney function and blood potassium levels.
Regular moderate exercise can help maintain overall health and manage symptoms of chronic kidney disease.
Frequently asked questions
Is Finerenone a steroid?
No, Finerenone is not a steroid. It is a non-steroidal mineralocorticoid receptor antagonist (MRA).
Does Finerenone have any effect on sleep?
There is currently no research data about the effects of Finerenone on sleep. Consult your doctor if you experience sleep disturbances while taking this medication.
Will Finerenone affect fertility?
Presently, there is no evidence to suggest that Finerenone affects fertility. If you have concerns about your fertility while taking this medication, it is recommended that you discuss them with your doctor.
Are there any particular diet restrictions while taking Finerenone?
As of now, there are no specific dietary restrictions associated with taking Finerenone. However, maintaining a balanced and healthy diet is always beneficial for overall health.
Is it safe to take Finerenone daily?
It is essential to adhere to the dosage and frequency recommended by your doctor.
How much time does Finerenone take to work?
The time required for Finerenone to show its effects may vary between individuals and depends on the condition being managed. For specifics, it would be best to consult with your doctor.
What is the best time to take Finerenone?
It is advisable to take it as advised by your doctor for better results.
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