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Filgrastim

Uses of Filgrastim

  • Filgrastim is used to manage neutropenia, a condition where there are abnormally low levels of neutrophils, a type of white blood cell. Filgrastim is part of the granulocyte colony-stimulating factors (G-CSF) class of medications.

  • It is also used in various situations such as helping cancer patients receiving chemotherapy to prevent infections due to low white blood cell counts, reducing the time for neutrophil recovery and fever duration in Acute Myeloid Leukemia (AML) patients after chemotherapy, promoting bone marrow recovery in cancer patients undergoing bone marrow transplant, increasing the yield of stem cells collected for autologous transplantation in patients undergoing peripheral blood progenitor cell collection, reducing the incidence and duration of infection-related events in severe chronic neutropenia, and treating radiation-induced myelosuppression or the hematopoietic syndrome of acute radiation syndrome in patients exposed to myelosuppressive doses of radiation.

Side effects of Filgrastim

  • Bone pain

  • Headache

  • Fatigue

  • Nausea

  • Vomiting

How Filgrastim works

  • Filgrastim is a granulocyte colony-stimulating factor (G-CSF).

  • It works by binding to specific receptors on certain blood cells in the bone marrow, which results in the stimulation of production, maturation, and activation of neutrophils. Neutrophils are a type of white blood cell that play a crucial role in the body's defence against infections. By accelerating the formation of new white blood cells in the bone marrow, Filgrastim effectively increases the number of circulating neutrophils in the blood within 24 hours, thereby enhancing the body's ability to fight off infections.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Filgrastim is available for use via subcutaneous or intravenous route in the form of a solution. The medication is typically administered as an injection under the skin or into a vein.

Age and Dose Restrictions

  • Filgrastim can be used in adults as well as in children who are old enough to receive chemotherapy or bone marrow transplants. The specific age range for its use can be determined by the attending doctor based on the patient's clinical condition.

Contraindications

  • Filgrastim is contraindicated in patients with known hypersensitivity to Escherichia coli-derived proteins, Filgrastim, or any component of the product.

  • It should not be used within 24 hours before or after receiving chemotherapy.

Other Medications to Avoid

  • Filgrastim may interact with lithium (e.g., lithium carbonate), medications that may cause kidney damage like non-steroidal anti-inflammatory drugs (e.g., ibuprofen and naproxen), aminoglycosides (e.g., gentamicin and tobramycin), and antifungals (e.g., amphotericin B and nystatin).

  • Before starting any prescription or over-the-counter medications, it is crucial to consult a doctor.

Overdose and Missed Dose

  • Overdose with Filgrastim may result in leukocytosis (excessively high white blood cell count). In case of overdose, supportive care is recommended. The medication should be discontinued, and the patient should be closely monitored for complications.

  • If you miss a dose of this medicine, contact your doctor immediately for further instructions.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.

  • Drinking plenty of fluids may help manage nausea or vomiting.

  • Resting often and avoiding strenuous activities could help manage fatigue.

Use in Driving and Operating Machinery

  • Filgrastim may cause side effects like dizziness or fatigue that could affect a person's ability to drive or operate heavy machinery. It is advisable to avoid these activities if such symptoms are experienced.

Use in Pregnancy and Lactation

  • Filgrastim should only be used in pregnancy or while breastfeeding if the benefit outweighs the potential risk. Always consult your doctor before using this medicine during these critical periods.

Caution in Other Conditions

  • Filgrastim should be used with caution in patients with sickle cell disease, as it might induce a sickle cell crisis.

  • Patients with pre-existing kidney disease or those receiving medications that may cause kidney damage should use this medicine cautiously.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in fruits, vegetables, lean proteins, and whole grains to support overall health and immune function.

  • Hydration is key for maintaining cellular function, including white blood cell activity. Aim to drink enough water each day.

  • Avoid exposure to people with infections, as patients taking Filgrastim might have weakened immune systems.

Frequently asked questions

Filgrastim is primarily used to manage neutropenia, a condition characterised by abnormally low levels of white blood cells. However, it is also used to stimulate the growth of white blood cells in patients undergoing certain treatments like chemotherapy, bone marrow transplants, and those exposed to myelosuppressive doses of radiation.

No, Filgrastim is not an antibiotic. It belongs to a class of medications known as granulocyte colony-stimulating factors (G-CSF). It stimulates the growth of white blood cells in the body, which play an important role in fighting infections.

Filgrastim can cause side effects such as fatigue, which may affect your mood. If you notice any unusual changes in your mood or behaviour while using this medication, consult your doctor.

Yes, Filgrastim can cause allergic reactions in some people. If you have a known allergy to Filgrastim or any of its components, you should avoid using this medication. Symptoms of an allergic reaction may include skin rash, itching, difficulty breathing, and swelling of the face or throat.

There is no specific information available about whether Filgrastim can affect menstruation. If you notice any changes in your menstrual cycle while using this medication, consult your doctor.

Some individuals might experience nausea and vomiting as side effects of Filgrastim, which can indirectly affect appetite. However, not everyone using this medication will experience these side effects.

There are no natural alternatives that can replace the specific action of Filgrastim. It is a man-made protein similar to a natural protein produced by the body. Always consult your doctor before making any changes to your medication.

Terms & Conditions


Filgrastim in other salts

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