Exemestane

Expert Advice

Dosage Forms Available

• Exemestane is available in the form of tablets.

• This medicine is taken orally.

Age and Dose Restrictions

• Exemestane is meant for use in adults, specifically postmenopausal women.

Contraindications

• This medicine is contraindicated in patients with known hypersensitivity to Exemestane or any of its excipients.

• It is also contraindicated in premenopausal women.

• Patients with severe hepatic impairment should avoid using this medicine.

Other Medications to Avoid

• Exemestane can interact with oestrogen-containing medications (such as hormone replacement therapies), CYP3A4 inducers (such as rifampin, phenytoin), and medications that affect bone metabolism (such as bisphosphonates, denosumab). It may also interact with blood pressure-lowering medications (such as amlodipine, lisinopril), anticoagulants (such as warfarin, dabigatran), and certain antiepileptic medications (such as carbamazepine, phenobarbital).

Overdose and Missed Dose

• In case of an overdose of Exemestane, there is no specific antidote available. The patient should be monitored for adverse reactions and given supportive care as needed. Hemodialysis is not expected to significantly enhance the removal of this medicine due to its high protein binding and extensive metabolism.

• If a dose of Exemestane is missed, it should be taken as soon as remembered unless it is almost time for the next dose. Do not take two doses at once.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• For side effects like increased sweating or hot flashes, staying hydrated by drinking adequate water might help.

• If experiencing joint pain or stiffness, adjusting activities to include gentle range-of-motion exercises may provide relief without the need for additional medication.

Use in Driving and Operating Machinery

• This medicine may impair your ability to drive or operate machinery. Caution is advised if you experience symptoms like dizziness after taking Exemestane.

Use in Pregnancy and Lactation

• Exemestane is not recommended during pregnancy and breastfeeding. It may cause harm to the foetus and there is potential for serious adverse reactions in nursing infants.

• It is crucial to consult a doctor before using this medicine during pregnancy or while breastfeeding.

Caution in Other Conditions

• Patients with a history of osteoporosis or bone fractures should use Exemestane with caution as it may increase bone loss.

• Although no dosage adjustment is necessary for patients with mild to moderate renal impairment, caution should be exercised in patients with severe renal impairment.

Special Dietary and Lifestyle Recommendations

• To help manage bone health due to an increased risk of bone loss associated with Exemestane, incorporating calcium-rich foods like dairy products, leafy greens, and fortified foods into your diet is beneficial.

• Vitamin D intake should be optimized to aid calcium absorption and bone health, through exposure to sunlight and consuming foods like fatty fish or fortified cereals.

• Engaging in regular weight-bearing exercises such as walking, jogging, or resistance training can strengthen bones.

• Avoiding smoking and limiting alcohol intake can also contribute positively to overall health and specifically bone health when managing conditions treated by Exemestane.

Frequently asked questions

Terms & Conditions