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Everolimus

Uses of Everolimus

  • The main use of Everolimus is for the management of various types of cancers, such as advanced kidney cancer, pancreatic neuroendocrine tumours, breast cancer, and brain tumours associated with tuberous sclerosis. It belongs to a group of medicines known as "mTOR inhibitors".

  • Everolimus is also used to prevent rejection in adult patients receiving kidney and liver transplants.

Side effects of Everolimus

  • Mouth sores or ulcers

  • Infections

  • Fatigue and weakness

  • Diarrhoea

  • Swelling of body parts

How Everolimus works

  • Everolimus is an immunosuppressant and anti-cancer medicine.

  • It belongs to the class of medicines known as mTOR inhibitors. In simple terms, it blocks the action of a protein called the mammalian target of rapamycin (mTOR). This protein plays a crucial role in controlling cell growth, multiplication, and survival. By blocking the action of this protein, Everolimus weakens the body's immune system, thereby helping in preventing the rejection of transplanted organs.

  • In terms of cancer management, this mechanism slows down the growth and spread of cancer cells by reducing their blood supply. Therefore, Everolimus effectively manages certain types of cancers and helps prevent organ transplant rejection by controlling the body's immune response.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Everolimus is available for oral consumption in the form of tablets.

Age and Dose Restrictions

  • Everolimus is typically prescribed for adult patients.

  • Its use in paediatrics needs careful consideration and should be under the direct supervision of a doctor.

Contraindications

  • Everolimus is contraindicated in patients with known hypersensitivity to the active substance or any component of the medication.

  • It is also contraindicated in patients with severe hepatic impairment, unless the benefits outweigh the risks.

Other Medications to Avoid

  • Everolimus may interact with antibiotics (e.g., erythromycin and clarithromycin), antifungal medications (e.g., ketoconazole and itraconazole), and anti-seizure medications (e.g., carbamazepine and gabapentin).

  • Other medicines like HIV protease inhibitors (e.g., ritonavir and atazanavir) and cardiac medicines (e.g., verapamil and diltiazem) can also interact with Everolimus.

Overdose and Missed Dose

  • An overdose of Everolimus can cause severe side effects ranging from mouth ulcers to kidney problems. If you suspect an overdose, immediately consult your doctor.

  • If you miss a dose of Everolimus, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed dose and continue with your regular schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

  • Drinking plenty of water can help manage side effects such as fatigue and dry mouth.

  • Taking the medication with food can help manage gastrointestinal symptoms.

Use in Driving and Operating Machinery

  • Everolimus can cause fatigue and weakness, which may affect your ability to drive or operate heavy machinery. Avoid these activities if you experience these side effects.

Use in Pregnancy and Lactation

  • Everolimus may cause harm to the foetus; hence, it is not recommended for use during pregnancy unless necessary.

  • It is not known if Everolimus passes into breast milk. Therefore, it is advised to consult your doctor before breastfeeding while taking this medication.

Caution in Other Conditions

  • Everolimus should be used with caution in patients with existing infections, diabetes, or high cholesterol levels.

  • Patients with liver disease may require dose adjustments as Everolimus is extensively metabolised by the liver.

Special Dietary and Lifestyle Recommendations

  • Consuming a balanced diet rich in fruits and vegetables can help the body recover during cancer treatment or organ transplant.

  • Regular, gentle physical activity such as walking can help manage fatigue associated with Everolimus therapy.

  • Adequate rest and sleep are vital for recovery and management of side effects.

  • Avoid alcohol consumption, as it can increase the risk of liver damage and other side effects.

  • Maintain good oral hygiene practices to reduce the incidence of mouth ulcers.

Frequently asked questions

No, Everolimus is not an antibiotic. It is an immunosuppressant and anti-cancer medication used to manage various types of cancers and to prevent rejection of organ transplants.

There is no direct evidence to suggest that Everolimus affects sleep. However, some side effects like fatigue and weakness might indirectly impact your sleep. Consult your doctor if you experience persistent sleep disturbances.

No, Everolimus is not a steroid. It is an immunosuppressant and an anti-cancer medication used to manage various types of cancers and to prevent rejection of transplanted organs.

The duration of treatment with Everolimus depends on your condition and response to the medication. For cancer, you may need to take it continuously as long as it is effective and side effects are manageable.

Everolimus is usually taken once daily as prescribed by your doctor. Always follow your doctor's instructions regarding the dosage and duration of treatment.

The time it takes for Everolimus to work can vary depending on the condition being managed. In cancer treatment, it may take several weeks or months to see a response.

Everolimus can be taken at any time of the day, with or without food, as prescribed by your doctor.

Terms & Conditions

Available medicines for EVEROLIMUS
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Suregraft 0.5 MG Tablet 10
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