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Epalrestat + Methylcobalamin

Uses of Epalrestat + Methylcobalamin

  • The primary use of Epalrestat + Methylcobalamin is for the management of diabetic neuropathy. This combination belongs to the class of aldose reductase inhibitors and vitamin B12 forms.

  • In addition, it may also be beneficial for managing symptoms related to vitamin B12 deficiency.

Side effects of Epalrestat + Methylcobalamin

  • Gastrointestinal issues such as nausea and abdominal pain

  • Headaches

  • Skin rash and itching

  • Fatigue

How Epalrestat + Methylcobalamin works

  • Epalrestat + Methylcobalamin is a combination medication for diabetic neuropathy management.

  • Epalrestat is an aldose reductase inhibitor. It blocks the enzyme that transforms excess glucose into sorbitol in cells. Too much sorbitol can harm nerve cells, and by reducing sorbitol build-up, Epalrestat helps manage diabetic nerve disease.

  • Methylcobalamin, an active form of Vitamin B12, aids in myelin production. Myelin is a fatty substance that protects nerve fibres, aiding in proper signal transmission. By promoting the formation of myelin, Methylcobalamin helps maintain nerve structure and function.

Certified content

Written By

docImg
Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Epalrestat + Methylcobalamin is available for use in the form of tablets and capsules. These are administered orally.

Age and Dose Restrictions

  • This medicine is intended for use by adults. It is not typically prescribed for children or adolescents under the age of 18 due to the specific nature and requirements of treatment for diabetic neuropathy, which this combination addresses.

Contraindications

  • Epalrestat + Methylcobalamin should not be used by individuals with an allergy to cobalt or cobalamin.

  • It is also contraindicated in patients who have Leber's hereditary optic neuropathy or tobacco amblyopia.

Overdose and Missed Dose

  • An overdose of Epalrestat + Methylcobalamin might lead to symptoms such as extreme fatigue, confusion, and gastrointestinal disturbances. If suspected, it is critical to seek immediate medical attention.

  • If you miss a dose of Epalrestat + Methylcobalamin, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If you experience mild gastrointestinal issues like nausea or abdominal pain, consider taking this medicine with food or after meals.

  • For those experiencing dizziness, resting immediately after taking the medication may help.

Use in Driving and Operating Machinery

  • Epalrestat + Methylcobalamin may cause side effects such as dizziness or drowsiness that could affect your ability to drive or operate machinery safely. It is advisable to avoid such activities if you experience these side effects.

Use in Pregnancy and Lactation

  • The safety of Epalrestat + Methylcobalamin during pregnancy and lactation has not been firmly established. Therefore, it is advised to consult a doctor before using this medication if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Individuals with liver or kidney disease should use Epalrestat + Methylcobalamin with caution. These conditions may affect how the medication is processed in the body.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in essential nutrients which can help manage diabetic neuropathy. Include foods high in B vitamins, antioxidants, omega fatty acids, and lean proteins.

  • Regular blood sugar monitoring is crucial for individuals with diabetes. Keeping blood glucose levels within recommended ranges can prevent further nerve damage.

  • Engage in moderate physical activities such as walking or swimming to improve blood circulation and nerve health. However, always ensure that any exercise routine is approved by your doctor to avoid complications due to neuropathy.

  • Avoid smoking and limit alcohol consumption as these can exacerbate diabetic complications including neuropathy.

  • Consider stress management techniques such as yoga or meditation to improve overall well-being and potentially reduce neuropathy pain.

Frequently asked questions

No, Epalrestat + Methylcobalamin does not contain any steroids. It is a combination medication consisting of an aldose reductase inhibitor (Epalrestat) and a form of vitamin B12 (Methylcobalamin).

This combination may take a few weeks to show noticeable symptom improvements, particularly in managing diabetic neuropathy. Still, the exact time can vary based on individual response and the severity of the condition.

This combination is not commonly associated with sleep disturbances, but in rare cases, individual reactions like insomnia or restlessness may occur. If you experience such effects, it's best to consult your doctor.

There is no evidence to suggest that there is a risk of becoming dependent on Epalrestat + Methylcobalamin. However, it is important always to use this medication as directed by your doctor.

Epalrestat + Methylcobalamin can interact with certain other medications, including metformin, blood thinners like warfarin, antibiotics like tetracycline, acid reflux medicines like omeprazole, and some vitamin and mineral supplements. Always inform your doctor about all medicines and supplements you are taking to avoid harmful interactions.

Yes, you can take Epalrestat + Methylcobalamin if you are vegan or vegetarian. However, as Methylcobalamin is a form of vitamin B12, which is often low in vegan and vegetarian diets, it is important to have regular blood tests to monitor your vitamin B12 levels while taking this medicine.

There is no known effect of Epalrestat + Methylcobalamin on mood or hormonal balance. However, if you notice any changes in your mood or other unexplained symptoms while taking this medication, consult your doctor.

Terms & Conditions


Epalrestat + Methylcobalamin in other salts

ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEASCORBIC ACID + BIOTIN + CALCIUM PANTOTHENATE + FOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + RIBOFLAVIN + THIAMINE MONONITRATE + ZINC SULPHATEELEMENTAL CALCIUM + L-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)METHYLCOBALAMIN + PREGABALINMETHYLCOBALAMINL METHYL FOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEPREGABALIN + NORTRIPTYLINE + METHYLCOBALAMINGABAPENTIN + METHYLCOBALAMINALFACALCIDOL + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + ELEMENTAL BORON + ELEMENTAL CALCIUM + FOLIC ACID + METHYLCOBALAMINMETHYLCOBALAMIN + THIOCTIC ACIDL METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINDHA + L-METHYLFOLATE + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEDULOXETINE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + ELEMENTAL CHROMIUM + INOSITOL + METHYLCOBALAMINDHA + L-METHYLFOLATE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEL-METHYLFOLATE + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMIN + PREGABALINALPHA LIPOIC ACID + GABAPENTIN + METHYLCOBALAMINBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE MONONITRATE + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + ELEMENTAL CHROMIUM + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENOMETHIONINE + ZINC MONOMETHIONINEALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM POLYNICOTINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENIUM DIOXIDEFOLIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + CHROMIUM PICOLINATE + METHYLCOBALAMIN + OMEGA 3 FATTY ACID + SELENIUM DIOXIDEALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + MYO INOSITOL + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)CITICOLINE + METHYLCOBALAMINELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACID + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DHA / DOCOSAHEXAENOIC ACID + EPA / EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + THIAMINE MONONITRATEBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + L METHYLFOLATE + MAGNESIUM + METHYLCOBALAMIN + VITAMIN K27 + ZINCDHA / DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)ELEMENTAL IRON + FOLIC ACID + METHYLCOBALAMINMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN C / ASCORBIC ACIDD-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDEMETHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 (PYRIDOXINE)D-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 (PYRIDOXINE)FERROUS ASCORBATE + FOLIC ACID + METHYLCOBALAMINEPALRESTATEPALRESTAT + PREGABALINAMITRIPTYLINE + METHYLCOBALAMINFOLIC ACID + L-CARNITINE / LEVOCARNITINE + METHYLCOBALAMINMETFORMIN + METHYLCOBALAMINCALCIUM-5 METHYLTETRAHYDROFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)D CHIRO INOSITOL + L-METHYLFOLATE + METFORMIN + METHYLCOBALAMIN + MYO INOSITOLFOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEL-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEFERROUS BISGLYCINATE + FOLIC ACID + METHYLCOBALAMIN + ZINC BISGLYCINATEFOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDEADENOSYLCOBALAMIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B1 + VITAMIN B2 + VITAMIN B6 (PYRIDOXINE)DIACEREIN + GLUCOSAMINE SULFATE POTASSIUM CHLORIDE + METHYL SULFONYL METHANE + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + FOLIC ACID + METHYLCOBALAMIN + OMEGA 3 FATTY ACIDALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE + VITAMIN B6 / PYRIDOXINE
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