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Doxylamine + Vitamin B6 (pyridoxine)

Uses of Doxylamine + Vitamin B6 (pyridoxine)

  • Doxylamine + Vitamin B6 (Pyridoxine) is primarily used for managing nausea and vomiting during pregnancy and it belongs to the classes of antihistamines and vitamins.

Side effects of Doxylamine + Vitamin B6 (pyridoxine)

  • Drowsiness

  • Dizziness

  • Headaches

  • Fatigue

  • Abdominal pain

How Doxylamine + Vitamin B6 (pyridoxine) works

  • Doxylamine + Vitamin B6 (Pyridoxine) is a combination medicine often used to manage nausea and vomiting during pregnancy.

  • Doxylamine is an antihistamine. It works by inhibiting the effects of histamine, a compound involved in allergic responses and sensations of nausea. This effectively reduces the frequency and severity of nausea and vomiting episodes.

  • Vitamin B6 (Pyridoxine) is a vital nutrient that plays an important role in our body's metabolism. It assists in the synthesis of essential neurotransmitters such as serotonin and GABA, chemicals in the brain that regulate mood and relaxation. Although its precise action for managing nausea during pregnancy is not fully understood, it is believed to alleviate symptoms by enhancing the production of these neurotransmitters.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Doxylamine + Vitamin B6 (Pyridoxine) is available in the form of delayed-release tablets.

  • This medication is taken orally.

Age and Dose Restrictions

  • This medicine is intended for use by adult women, specifically those who are pregnant.

Contraindications

  • Doxylamine + Vitamin B6 (Pyridoxine) is contraindicated in individuals with known hypersensitivity to doxylamine, other ethanolamine-derivative antihistamines, or pyridoxine.

  • It is also contraindicated in patients with asthma, increased intraocular pressure, narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder neck obstruction.

Other Medications to Avoid

  • This combination may interact with monoamine oxidase inhibitors (such as phenelzine and tranylcypromine), CNS depressants (like alprazolam and zolpidem), and other anticholinergic agents (such as atropine and scopolamine).

  • Before starting any new medications, consulting a doctor is essential to avoid adverse interactions.

Overdose and Missed Dose

  • An overdose of Doxylamine + Vitamin B6 (Pyridoxine) might lead to increased severity of side effects such as severe drowsiness and anticholinergic effects like dry mouth and enlarged pupils. In such cases, contacting a doctor immediately is crucial.

  • If a dose of this medicine is missed, it should be taken as soon as remembered unless it is near the time for the next dose. Do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage drowsiness, consider taking the medicine at bedtime to ensure sleep is not disrupted.

  • If experiencing mild dizziness, ensure to sit or lie down until the feeling passes.

Use in Driving and Operating Machinery

  • This medication can cause drowsiness. You should avoid driving or operating heavy machinery until you have determined how Doxylamine + Vitamin B6 (Pyridoxine) affects your ability to perform these activities safely.

Use in Pregnancy and Lactation

  • Doxylamine + Vitamin B6 (Pyridoxine) is specifically approved for use during pregnancy for managing nausea.

  • The safety of this medication during breastfeeding has not been conclusively established. Consult your doctor before using this medication if breastfeeding.

Caution in Other Conditions

  • Individuals with conditions that affect metabolism or excretion, such as liver or kidney disease, should use Doxylamine + Vitamin B6 (Pyridoxine) with caution.

  • Patients with these conditions should discuss their health status with their doctor before beginning treatment.

Special Dietary and Lifestyle Recommendations

  • To aid in managing nausea and vomiting during pregnancy, small, frequent meals throughout the day may help.

  • Staying hydrated by drinking plenty of fluids can also be beneficial.

  • Avoiding spicy and fatty foods might reduce nausea incidents.

  • Engaging in light activities such as walking can aid digestion and help manage symptoms.

  • Ensure a well-ventilated environment as certain smells can trigger nausea.

Frequently asked questions

Doxylamine + Vitamin B6 (Pyridoxine) primarily manages nausea and vomiting during pregnancy. However, some side effects related to the nervous system and mood can occur, including dizziness, headaches, and irritability. If you experience any mood changes while taking this medication, consult your doctor immediately.

Yes, Doxylamine has been shown to cross-react with immunoassays for certain substances like methadone, opiates, and PCP, potentially leading to false-positive results on urine drug screens. If you are subject to regular drug testing, you should inform your doctor and the testing lab that you are taking this medication.

Doxylamine + Vitamin B6 (Pyridoxine) is not known to directly affect appetite. However, since it effectively manages nausea and vomiting during pregnancy, it may indirectly improve your appetite by reducing these symptoms.

No, Doxylamine + Vitamin B6 (Pyridoxine) does not cause dependency or addiction as per the provided research data.

The ingredients of this medication do not inherently contain any animal-derived products. However, you should check the specific formulation of your prescribed medication for any added non-vegan components such as gelatine in capsules or other inactive ingredients.

If prescribed by your doctor, you may use this medication for a long time. Adhere to your doctor's instructions.

Relief from symptoms like nausea can be noticed within a few hours of taking the combination, with the full benefits observed over several days.

Terms & Conditions


Doxylamine + Vitamin B6 (pyridoxine) in other salts

ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)BENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)CYANOCOBALAMIN + L-LYSINE + NICOTINAMIDE + SORBITOL + VITAMIN B6 (PYRIDOXINE)METHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 (PYRIDOXINE)D-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 (PYRIDOXINE)CALCIUM + CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + IRON + PHOSPHORUS + POTASSIUM + SODIUM + VITAMIN A + VITAMIN B1 + VITAMIN B2 + VITAMIN B3 + VITAMIN B5 (PANTOTHENIC ACID) + VITAMIN B6 (PYRIDOXINE) + VITAMIN C / ASCORBIC ACID + VITAMIN EDOXYLAMINE + VITAMIN B6 / PYRIDOXINEDOXYLAMINE + FOLIC ACID + VITAMIN B6 / PYRIDOXINEADENOSYLCOBALAMIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B1 + VITAMIN B2 + VITAMIN B6 (PYRIDOXINE)DOXYLAMINE + FOLIC ACID + VITAMIN B6 (PYRIDOXINE)
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