Doxorubicin (liposomal)
Uses of Doxorubicin (liposomal)
Doxorubicin (Liposomal) is primarily used to manage various types of cancer, including ovarian cancer, AIDS-related Kaposi's sarcoma, and multiple myeloma. It falls under the category of anti-cancer medicines.
Side effects of Doxorubicin (liposomal)
Fatigue and weakness
Mouth sores and oral ulcers
Nausea and vomiting
Low blood cell counts
How Doxorubicin (liposomal) works
Doxorubicin (Liposomal) is an anthracycline type of chemotherapy medication.
It works by inserting itself between the DNA base pairs, which are the building blocks of DNA. This process, known as intercalation, disrupts the DNA and RNA synthesis in cancer cells that are rapidly dividing, leading to their death.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Doxorubicin (Liposomal) can be administered intravenously (infusion).
Age and Dose Restrictions
Doxorubicin (Liposomal) is generally prescribed for adult patients aged 18 and above.
Contraindications
This medicine is contraindicated in patients with known hypersensitivity to doxorubicin or any component of the liposomal formulation. It is also contraindicated in lactating mothers.
Other Medications to Avoid
Doxorubicin (Liposomal) can interact with cardiotoxic medicines (such as trastuzumab, paclitaxel), and chemotherapy agents (like cyclophosphamide, etoposide, cisplatin).
Overdose and Missed Dose
Overdose of Doxorubicin (Liposomal) may lead to serious health complications due to its potent anticancer effects. In case of a suspected overdose, immediate medical intervention is required.
If a dose is missed, it should be administered as soon as remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped. Doses should not be doubled to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Administering the medication with meals can help manage nausea and vomiting.
Increasing fluid intake may help manage constipation and diarrhoea.
Use in Driving and Operating Machinery
Since Doxorubicin (Liposomal) has potential side effects like dizziness and fatigue, it may impair your ability to drive or operate heavy machinery. It is advised to refrain from such activities until you know how this medicine affects you.
Use in Pregnancy and Lactation
Doxorubicin (Liposomal) is not recommended for use during pregnancy or breastfeeding due to potential risks to the foetus or infant.
Caution in Other Conditions
Doxorubicin (Liposomal) should be used with caution in patients with mild to moderate liver impairment.
Patients with pre-existing heart conditions should be closely monitored during treatment due to the risk of cardiotoxicity.
Special Dietary and Lifestyle Recommendations
Regular follow-ups with the doctor are necessary to monitor treatment response and side effects.
Frequently asked questions
Does Doxorubicin (Liposomal) have any effect on mood or emotions?
No, Doxorubicin (Liposomal) is used to manage various types of cancer, and it does not directly affect mood or emotions. However, the overall experience of dealing with a serious illness like cancer and its treatment may indirectly influence your emotional well-being.
Can natural alternatives replace Doxorubicin (Liposomal)?
No, Doxorubicin (Liposomal) is an anti-cancer medication that has been scientifically tested and proven to be effective in managing certain types of cancer. Natural alternatives cannot replace its function.
Can allergies trigger any reactions to Doxorubicin (Liposomal)?
Yes, if you are allergic to Doxorubicin (Liposomal) or any of its components, you may experience allergic reactions. Symptoms may include itching, rash, difficulty breathing, and swelling of your face, lips, tongue or throat.
Can I develop a dependency on Doxorubicin (Liposomal)?
No, Doxorubicin (Liposomal) is an anti-cancer medication and there is no risk of addiction or dependency associated with its use.
What are the alternative salts similar to Doxorubicin (Liposomal)?
There are other anthracycline medications similar to Doxorubicin (Liposomal) such as Epirubicin and Daunorubicin. However, these medicines have different chemical structures and may not work the same way as Doxorubicin (Liposomal).
How long does Doxorubicin (Liposomal) stay in the body?
The half-life of Doxorubicin (Liposomal) varies between individuals but is typically around 55 hours. This means that approximately half of the medicine will be eliminated from the body within this period. However, elimination can take longer for certain patients.
Can I administer Doxorubicin (Liposomal) on an empty stomach?
As Doxorubicin (Liposomal) is administered intravenously, food in the stomach does not impact its administration or absorption.
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