Doxepin is primarily used to manage depression and anxiety disorders. It belongs to a group of medicines called tricyclic antidepressants.
Other secondary uses of Doxepin include managing insomnia characterised by difficulties in sleep maintenance, and providing relief from itching and skin irritation when used topically for conditions like atopic dermatitis and lichen simplex chronicus.
Drowsiness
Dizziness
Dry mouth
Constipation
Weight gain
Doxepin is a type of medicine known as a tricyclic antidepressant.
It operates by blocking the reuptake of mood-enhancing neurotransmitters, specifically serotonin and norepinephrine, in the brain. This increases their concentration and enhances their effects, helping to lift mood, relieve depression and anxiety, and improve sleep.
Doctor of Medicine
BMS, FMC, MD Resident
Doxepin is available for use via the oral route in the form of capsules and solutions.
A topical cream formulation of Doxepin is also available for application on the skin.
This medicine is recommended for use in adults. Doxepin is not intended for use in children under 12 years of age.
Doxepin is contraindicated in patients with known hypersensitivity to the medicine or any of its inactive ingredients.
It should not be used by patients suffering from glaucoma or those with a history of urinary retention problems.
Doxepin may interact with Monoamine Oxidase Inhibitors (MAOIs) (such as phenelzine and tranylcypromine), Central Nervous System (CNS) depressants (like benzodiazepines and opioids), and anticholinergic medicines (like atropine and scopolamine).
An overdose of Doxepin may result in symptoms such as severe drowsiness, confusion, hallucinations, seizures, and cardiac abnormalities. It requires immediate medical attention.
If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
Drinking plenty of fluids may help reduce dry mouth caused by Doxepin.
To manage dizziness or feeling faint that may occur when standing up from a sitting or lying position, get up slowly.
Doxepin may cause drowsiness, dizziness, and impaired concentration which may affect your ability to drive or operate heavy machinery. Avoid these tasks if you experience these effects after taking the medicine.
The use of Doxepin is not recommended during pregnancy unless necessary and the benefits outweigh the risks. Breastfeeding mothers should avoid using Doxepin as it may pass into breast milk and cause sedation in the breastfed infant.
Patients with heart conditions, liver diseases or those with a history of urinary retention or glaucoma should exercise caution when taking Doxepin.
Maintain a regular sleep schedule to improve sleep quality when using Doxepin for insomnia.
Engage in relaxation exercises such as deep breathing techniques or meditation to help manage anxiety symptoms.
Try eating small, frequent meals if Doxepin causes an upset stomach.
Frequently asked questions
No, Doxepin is not a steroid. It is a tricyclic antidepressant, which is a group of medicines used to help manage certain mental health conditions such as depression and anxiety.
Yes, Doxepin can affect sleep. It is sometimes used to manage insomnia, specifically sleep maintenance problems. Therefore, it might make you feel sleepy or drowsy.
Doxepin is not commonly known to significantly affect fertility. If you have concerns, consult your doctor.
Yes, it is safe to take Doxepin daily if your doctor has instructed you to do so. The dosage and duration of treatment will depend on your medical condition.
The time taken by Doxepin to work can depend on the condition being managed and the individual's response. Usually, some improvement in symptoms may be noticed within one to two weeks.
The best time to take Doxepin would be as advised by your doctor. For managing sleep disorders, it is usually recommended to take it within 30 minutes before bedtime.
The duration of treatment with Doxepin will be determined by your doctor based on your medical condition and response to therapy.
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