Doripenem
Uses of Doripenem
Doripenem is primarily used to manage serious bacterial infections in hospitalised patients and is a part of the carbapenem class of antibiotics.
Doripenem can help manage infections such as complicated intra-abdominal infections and complicated urinary tract infections, as long as they are caused by bacterial strains that are susceptible to the medication.
Side effects of Doripenem
Headaches
Nausea
Diarrhoea
Rash
Inflammation of the vein at the infusion site
How Doripenem works
Doripenem is a broad-spectrum carbapenem antibiotic.
It works by inhibiting the synthesis of the bacterial cell wall, an essential component for bacterial survival. Specifically, Doripenem binds to and deactivates enzymes called penicillin-binding proteins (PBPs), which are crucial in making the bacterial cell wall. When the bacterial cell wall is compromised, it leads to the breakdown or lysis of the bacterial cell, leading to its death. This action helps manage severe bacterial infections effectively.
Certified content
Written By
Doctor of Medicine
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
- Doripenem can be administered intravenously (infusion).
Age and Dose Restrictions
- Doripenem is intended for adult use.
Contraindications
- Doripenem is contraindicated in patients who have severe hypersensitivity to doripenem or any other carbapenem. It should also be avoided in patients with known allergies to penicillins or cephalosporins, due to possible cross-reactivity.
Other Medications to Avoid
- Doripenem may interact with antigout medications (e.g., Probenecid, Allopurinol) and anti-seizure medications (e.g., valproic acid, divalproex sodium).
Overdose and Missed Dose
- Overdose of Doripenem could potentially result in an increased incidence of adverse reactions. If an overdose is suspected, consult your doctor immediately.
- If you miss a dose of Doripenem, administer it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
- Drink plenty of fluids to help deal with side effects such as headaches.
- Rest and avoid physical exertion if you experience symptoms like fatigue or dizziness.
Use in Driving and Operating Machinery
- Doripenem may cause dizziness or drowsiness in some patients. If you experience these symptoms, avoid driving or operating heavy machinery until you are sure of how this medicine affects you.
Use in Pregnancy and Lactation
- This medicine is not recommended during pregnancy and lactation unless prescribed by your doctor. It is advised to consult your doctor before using this medicine during pregnancy or lactation.
Caution in Other Conditions
- Caution should be exercised when administering Doripenem to patients with moderate to severe renal impairment. Dose adjustment may be required based on the patient's creatinine clearance.
- Patients with central nervous system disorders, such as epilepsy or a history of seizures, should also exercise caution, as Doripenem may increase the risk of seizures.
Special Dietary and Lifestyle Recommendations
- Drink plenty of fluids to support kidney function and help flush out the medication from your system.
Frequently asked questions
Is Doripenem a type of steroid?
No, Doripenem is not a steroid. It is an antibiotic that belongs to the carbapenem class of medicines.
Can Doripenem have any impact on my sleep?
Doripenem is not known to affect sleep. However, if you experience unusual sleep patterns after starting the medication, consult your doctor immediately.
Will taking Doripenem affect my fertility?
Doripenem is not known to have any impact on fertility. If you have any concerns about this, it would be best to consult your doctor.
Is it safe to take Doripenem daily?
The daily intake of Doripenem depends upon the severity and type of bacterial infection you have. It is imperative to follow your doctor's prescription strictly regarding the dosage and duration of the medicine.
How long does it take for Doripenem to work?
The time taken by Doripenem to show its effect varies depending on the type and severity of the infection being managed. For precise information, you should follow your doctor's advice.
When is the best time to administer Doripenem?
Doripenem should be administered as per your doctor's instructions. The timings can vary based on the severity and type of infection being managed.
Can Doripenem cause allergic reactions?
Yes, Doripenem can cause serious allergic reactions in patients with known hypersensitivity to carbapenem. Symptoms may include rash, itching, difficulty breathing or swallowing, and severe dizziness. Consult your doctor, if they persist or worsen.
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