Domperidone + Omeprazole
ANTIEMETIC/ANTACIDUses of Domperidone + Omeprazole
- Domperidone + Omeprazole is used together to treat conditions related to the digestive system, such as heartburn, indigestion, epigastric pain, gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. Domperidone helps improve gastric motility and reduce nausea, while Omeprazole reduces stomach acid production, providing relief from symptoms and promoting healing of the gastrointestinal tract.
Side effects of Domperidone + Omeprazole
- Headache
- Diarrhoea
- Abdominal pain
- Flatulence
- Dry mouth
How Domperidone + Omeprazole works
- Domperidone is a medication that helps prevent nausea and vomiting. It works by blocking dopamine receptors but doesn’t easily cross into the brain, so side effects like muscle spasms and tremors are very rare in adults. However, domperidone can increase the production of prolactin, a hormone from the pituitary gland. Its effectiveness in preventing nausea comes from its ability to speed up stomach emptying and block dopamine receptors in a part of the brain that triggers vomiting.
- Omeprazole is a medication made up of two different forms of the same molecule. It reduces stomach acid by targeting the acid pump in the stomach's parietal cells. It works quickly and effectively by reversibly inhibiting the production of stomach acid.
Certified content
Written By
Amit SharmaClinical Health & Medical Writer| 3 years
B. Pharm
Reviewed By
Amatul Ameen Clinical Health & Medical Writer| 13 years
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- This combination is available for use via the oral route (delayed-release tablets and suspension).
Age and Dose Restrictions
- The combination is meant for adults and children above 12 years of age.
Contraindications
- Domperidone + Omeprazole is contraindicated in patients with known allergies to domperidone or omeprazole, who have prolactinoma and severe liver issues.
Other Medications To Avoid With This Medicine
- It is advised against concurrent use of painkillers (aspirin), antibiotics (ciprofloxacin), statins (atorvastatin), anti-HIV medications (atazanavir), blood-thinning medications (clopidogrel, warfarin, cilostazol), levothyroxine for hypothyroidism, anti-fungal medications (ketoconazole, itraconazole, voriconazole), anti-cancer medications (erlotinib, methotrexate), anti-depressants (citalopram, escitalopram, duloxetine), anti-anxiety medications (alprazolam), vitamins (cyanocobalamin), anti-convulsants (phenytoin), gastroprokinetic medications (cisapride), cardiac glycosides (digoxin), immunosuppressants (tacrolimus), and anti-tuberculosis medications (rifampicin) along with Domperidone + Omeprazole. Prior consultation with your doctor is essential before initiating any prescription or over-the-counter medications.
Overdose and Missed Dose
- Overdose of this combination can cause confusion, drowsiness, blurred vision, tachycardia, nausea, vomiting, diaphoresis, flushing, headache, and dry mouth. Inform your doctor regarding these effects and follow the advice accordingly.
- If you forget to take this combination, take it as soon as you remember, but avoid repeating the dose.
Use In Driving And Operating Machinery
- This combination may affect your ability to drive or operate heavy machinery. Avoid driving if you feel dizzy after taking this combination.
Use in Pregnancy and Lactation
- This combination is not recommended during pregnancy or breastfeeding.
Special Dietary & Lifestyle Recommendation
- Avoid alcohol when you are taking Domperidone + Omeprazole.
- Individuals with a history of GERD should consider lifestyle modifications, including dietary changes such as adopting a GERD-friendly diet, emphasising low-acid foods, avoiding spicy and fatty meals, and reducing portion sizes in conjunction with this combination.
- It is best to take this combination before meals.
Frequently asked questions
1. How much time does Domperidone + Omeprazole take to work?
This combination starts showing its effect within a few hours after consumption.
2. What warnings and precautions should I take while taking Domperidone + Omeprazole?
Avoid taking this combination if you experience hypersensitivity or allergic reactions to any of its components. Promptly seek medical advice in such cases.
3. Can I stop taking Domperidone + Omeprazole if I feel healthy?
Do not stop taking this combination without consulting your doctor, even if you feel healthy.
4. Is it safe for patients with kidney or liver issues?
Consult your doctor before taking this combination if you have kidney or liver issues to ensure its safety and proper dosage.
Domperidone + Omeprazole in other salts
DOMPERIDONE + RABEPRAZOLEESOMEPRAZOLEESOMEPRAZOLE + LEVOSULPIRIDEOMEPRAZOLEDOMPERIDONE + ESOMEPRAZOLEDOMPERIDONENAPROXEN + DOMPERIDONEDEXRABEPRAZOLE + DOMPERIDONEDICLOFENAC + OMEPRAZOLECINNARIZINE + DOMPERIDONEESOMEPRAZOLE + ITOPRIDEDOMPERIDONE + ILAPRAZOLEDOMPERIDONE + LAFUTIDINEDOMPERIDONE + LANSOPRAZOLEDOMPERIDONE + RANITIDINEAMOXICILLIN + OMEPRAZOLE + TINIDAZOLEAMOXICILLIN + CLARITHROMYCIN + ESOMEPRAZOLEDOMPERIDONE + SUCRALFATEDOMPERIDONE + MAGALDRATE + SIMETHICONEDOMPERIDONE + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + FLUNARIZINE + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + RANITIDINE + SIMETHICONEDOMPERIDONE + PARACETAMOL/ACETAMINOPHEN + TRAMADOLESOMEPRAZOLE + NAPROXENDICYCLOMINE + OMEPRAZOLE
Available medicines for DOMPERIDONE + OMEPRAZOLE
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