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Domperidone + Magaldrate + Simethicone

Uses of Domperidone + Magaldrate + Simethicone

  • The primary use of Domperidone + Magaldrate + Simethicone is to manage symptoms of various gastrointestinal issues such as acidity, stomach ulcers, and bloating. This combination belongs to a class of medicines known as gastroprokinetic and antacid agents.

  • Along with the primary uses, this combination is also used in managing symptoms of gastroesophageal reflux disease (GERD) and providing relief from gas-related discomfort.

Side effects of Domperidone + Magaldrate + Simethicone

  • Dry mouth

  • Headache

  • Diarrhea

  • Constipation

  • Drowsiness

  • Dizziness

  • Rare cases of breast enlargement or discharge

How Domperidone + Magaldrate + Simethicone works

  • Domperidone + Magaldrate + Simethicone is a combination of a dopamine antagonist, antacid, and anti-foaming agent.

  • Domperidone, being a dopamine antagonist, works by tightening the muscles at the entrance and relaxing the muscles at the exit of the stomach. This action helps reduce nausea and vomiting by blocking messages between your digestive system and brain.

  • Magaldrate is an antacid that neutralizes excess stomach acid. This component forms a protective layer within the stomach and encourages the healing process in case of ulcers.

  • Simethicone, an anti-foaming agent, breaks up gas bubbles in your digestive tract. This action aids in relieving bloating, pressure and abdominal discomfort caused by excess gas in your system.

  • Together, these components work comprehensively to manage various gastrointestinal symptoms such as acidity, ulcers, and bloating effectively.

Certified content

Written By

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Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Domperidone + Magaldrate + Simethicone is available in oral formulations such as chewable tablets and suspension for oral use. It is also available in the form of a gel which is also to be taken orally.

Age and Dose Restrictions

  • This medication is recommended for use in adults and children aged 12 years and above.

Contraindications

  • Domperidone + Magaldrate + Simethicone is contraindicated in patients with known allergies to any of the three active ingredients.

  • Patients with liver or kidney disease, heart problems, or electrolyte imbalances should use this medicine cautiously.

Other Medications to Avoid

  • Domperidone + Magaldrate + Simethicone may interact with antibiotics (e.g., erythromycin, clarithromycin), antifungals (e.g., ketoconazole, itraconazole), antidepressants, antipsychotics, heart medications (e.g., quinidine, disopyramide, amiodarone), HIV medications, and Parkinson's disease medications.

  • Always discuss all current medications and supplements with your doctor before starting this combination.

Overdose and Missed Dose

  • Overdosing on Domperidone + Magaldrate + Simethicone can lead to symptoms like irregular heartbeat, fainting, or allergic reactions. In such cases, seek immediate medical attention.

  • If you miss a dose of this medicine, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage side effects like dry mouth and constipation.

  • Resting or lying down can help if you feel dizzy or drowsy after taking this medicine.

Use in Driving and Operating Machinery

  • Domperidone + Magaldrate + Simethicone may cause drowsiness or dizziness. It is advised to avoid driving or operating heavy machinery if you experience these side effects after taking this medication.

Use in Pregnancy and Lactation

  • The safety of Domperidone + Magaldrate + Simethicone during pregnancy and breastfeeding is not well-established. Please consult your doctor before using this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with liver disease, kidney disease, heart problems, or electrolyte imbalances should exercise caution when using Domperidone + Magaldrate + Simethicone. Always consult your doctor before starting this medication.

Special Dietary and Lifestyle Recommendations

  • Avoiding spicy and fatty foods can help manage acidity and heartburn.

  • Limiting intake of caffeine, carbonated drinks, and alcohol may also help in managing gastrointestinal symptoms.

  • Regular physical activity can support digestion and reduce symptoms like bloating and gas.

Frequently asked questions

No, this combination is not a steroid. It comprises two gastrointestinal agents (Domperidone and Magaldrate) and an anti-foaming agent (Simethicone), which together manage various gastrointestinal symptoms like acidity, ulcers, and bloating.

The combination of Domperidone, Magaldrate, and Simethicone does not directly affect sleep. However, if excessive gas, bloating or acidity was causing discomfort and affecting your sleep, managing these symptoms might indirectly improve your sleep quality.

There is no established evidence to suggest that this combination affects fertility. However, if you have concerns about this, it is advisable to consult your doctor.

While certain natural remedies, such as dietary changes and herbal supplements, may help manage some gastrointestinal symptoms, they should not replace prescribed medication without a doctor's approval. Always consult your doctor before making any changes to your medication regimen.

You can take this medication with milk unless otherwise advised by your doctor. Milk is generally neutral and should not interfere with the action of the medicine.

There are no established reports linking this combination to weight gain. However, individual responses can vary and if you notice any significant changes in weight while taking this medicine, it is advised to consult with your doctor.

Yes, you can continue your usual exercise routine while taking this medicine. Regular exercise is generally good for overall health and may even help manage some gastrointestinal symptoms.

Terms & Conditions


Domperidone + Magaldrate + Simethicone in other salts

ALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONEDOMPERIDONE + OMEPRAZOLEDOMPERIDONE + RABEPRAZOLEDOMPERIDONE + ESOMEPRAZOLEDOMPERIDONENAPROXEN + DOMPERIDONEDEXRABEPRAZOLE + DOMPERIDONEALUMINIUM HYDROXIDE + MAGNESIUM ALUMINIUM SILICATE HYDRATE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONECINNARIZINE + DOMPERIDONESIMETHICONEDOMPERIDONE + ILAPRAZOLEDOMPERIDONE + LAFUTIDINEDOMPERIDONE + LANSOPRAZOLEALPHA AMYLASE + PAPAIN + SIMETHICONEDOMPERIDONE + RANITIDINEDIASTASE + PEPSIN + SIMETHICONEDICYCLOMINE + SIMETHICONEDILL OIL + FENNEL OIL + SIMETHICONEMAGALDRATE + OXETACAINE + SIMETHICONEMAGALDRATE + SIMETHICONEALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONE + SODIUM CARBOXYMETHYL CELLULOSEALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + OXETACAINE + SIMETHICONEALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONE + SORBITOLALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONE + SODIUM ALGINATEDOMPERIDONE + SUCRALFATEMETRONIDAZOLE + OFLOXACIN + SIMETHICONEALUMINIUM HYDROXIDE + LIQUORICE EXTRACT + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONEALGINIC ACID + ALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONEDOMPERIDONE + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + FLUNARIZINE + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + RANITIDINE + SIMETHICONEDILOXANIDE + SIMETHICONE + TINIDAZOLEDICYCLOMINE + MAGALDRATE + OXETACAINE + SIMETHICONEDOMPERIDONE + PARACETAMOL/ACETAMINOPHEN + TRAMADOLCISAPRIDE + SIMETHICONEBILE CONSTITUENTS + PANCREATIN + SIMETHICONEACTIVATED CHARCOAL + SIMETHICONEDICYCLOMINE + MEFENAMIC ACID + SIMETHICONE
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