Domperidone + Lafutidine is primarily used to manage various gastrointestinal disorders including gastroesophageal reflux disease (GERD) and peptic ulcers. It belongs to the class of gastroprotective and prokinetic medications.
Secondary uses of Domperidone + Lafutidine include managing non-ulcer dyspepsia and relieving symptoms like stomach pain, bloating, and feeling of fullness. It is also used as an add-on treatment for the eradication of Helicobacter pylori (H. pylori) bacteria.
Headache
Dizziness
Dry mouth
Diarrhoea
Abdominal pain
Domperidone is a dopamine-2 receptor antagonist. It increases the contractions of the stomach and its emptying speed. It also prevents feelings of nausea and vomiting by blocking dopamine receptors in the brain.
Lafutidine is an H2-receptor antagonist. It limits the production of stomach acid by blocking histamine's action on cells in the stomach lining. Additionally, it supports the gastric mucosa, the stomach's protective layer, by increasing mucus secretion and enhancing blood flow.
When working together, Domperidone and Lafutidine help minimise acid reflux, speed up ulcer healing, and provide respite from unpleasant gastrointestinal symptoms.
Doctor of Medicine
BMS, FMC, MD Resident
Domperidone + Lafutidine is available for oral administration in two forms: tablet and capsule.
This medicine is meant for use in adults over 18 years of age.
This medicine is contraindicated in patients with known hypersensitivity to Domperidone or Lafutidine.
It is also contraindicated in patients with prolactinoma, pituitary tumours, gastrointestinal perforation or obstruction, and moderate to severe liver impairment.
Domperidone + Lafutidine may interact with antacids and proton pump inhibitors (such as omeprazole and lansoprazole), strong CYP3A4 inhibitors (like ketoconazole, itraconazole), QT-prolonging medicines (such as quinidine, amiodarone), anticholinergic medicines (like hyoscine, atropine) and cardiac glycosides (like digoxin).
An overdose of Domperidone + Lafutidine may lead to symptoms such as confusion, disorientation and difficulty in walking and speaking. If you suspect an overdose, consult your doctor immediately.
If you forget to take a dose of this medicine, take it as soon as you remember. However, if it’s almost time for the next dose, skip the missed dose and take the next one at the regular time. Do not double the dose.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Staying hydrated can help manage side effects like dry mouth and constipation.
Taking this medicine with food can help reduce side effects such as abdominal pain and diarrhoea.
Rest techniques can help manage side effects like headaches and dizziness.
Domperidone + Lafutidine may cause dizziness or drowsiness. If you experience these symptoms, avoid driving or operating heavy machinery until you feel alert again.
Consult your doctor before using Domperidone + Lafutidine during pregnancy and breastfeeding.
Patients with kidney disease or liver impairment should exercise caution when taking Domperidone + Lafutidine. Regular monitoring of kidney function and liver function may be required during treatment with this medicine.
A diet low in spicy, acidic, and fatty foods can help manage symptoms of gastroesophageal reflux disease (GERD) and peptic ulcers.
Regular moderate-intensity exercise can improve digestion and reduce stress, both of which can help manage gastrointestinal disorders.
Frequently asked questions
No, Domperidone + Lafutidine is not a steroid. It is a combination of two active medicinal ingredients domperidone, a dopamine-2 receptor antagonist, and lafutidine, an H2-receptor antagonist. The combination is primarily used to manage various gastrointestinal disorders.
Domperidone + Lafutidine does not typically cause sleep disturbances. However, individuals can experience different reactions to medicines, and if you experience any unusual effects on your sleep, consult your doctor.
Domperidone + Lafutidine is not associated with having an impact on an individual's fertility. If you have concerns about this issue, it is advisable to discuss them with your doctor.
Domperidone + Lafutidine can be taken daily if prescribed by your doctor for managing certain medical conditions like GERD and peptic ulcers.
The time it takes for Domperidone + Lafutidine to work can vary depending on the individual and the condition being managed. Your doctor will be able to provide more specific information based on your situation.
Domperidone + Lafutidine is typically recommended to be taken before meals. However, the best time to take this medicine can vary depending on your specific condition and how your body responds to medication. Your doctor will guide you on the optimal time to take this medicine.
No, Domperidone + Lafutidine is not known to cause dependency or habit formation. It should be taken exactly as prescribed by your doctor.
Domperidone + Lafutidine in other salts
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