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Diacerein

Uses of Diacerein

  • Diacerein is primarily used in the management of symptomatic osteoarthritis, specifically in the knee and hip joints, and falls under the category of anthraquinone medications.

  • It is often prescribed as a long-term therapy to reduce pain, stiffness, and functional limitations associated with this condition.

Side effects of Diacerein

  • Diarrhoea

  • Abdominal pain

  • Soft stools

  • Urine discoloration

  • Skin rash

How Diacerein works

  • Diacerein is an anthraquinone class of medicine.

  • It works by inhibiting the production and activity of interleukin-1 beta (IL-1β), a key inflammatory mediator in osteoarthritis. This reduces inflammation and associated symptoms in osteoarthritis. Diacerein also reduces the sensitivity of cells to IL-1 by decreasing the number of IL-1 receptors on chondrocytes (cartilage cells).

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Diacerein is primarily available in the form of oral capsules.

Age and Dose Restrictions

  • Diacerein is intended for use in adults.

Contraindications

  • Diacerein is contraindicated in patients with hypersensitivity to diacerein or any components of the formulation. It should be avoided in individuals with severe liver or kidney disease.

Other Medications to Avoid

  • Diacerein may interact with diuretics (such as furosemide and hydrochlorothiazide). It should be used cautiously with cardiac glycosides (like digoxin and digitoxin).

Overdose and Missed Dose

  • Overdosing on Diacerein can cause an increase in the severity of side effects, particularly gastrointestinal disturbances. If you suspect an overdose, contact your doctor immediately.

  • If you miss a dose of Diacerein, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For mild gastrointestinal side effects such as diarrhoea or abdominal pain, consider taking the medication with meals.

  • Stay hydrated to help manage diarrhoea.

  • Ensure adequate rest to manage fatigue or dizziness.

Use in Driving and Operating Machinery

  • Diacerein might cause dizziness or fatigue in some individuals. If you experience such symptoms, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Diacerein is not recommended for use during pregnancy or lactation.

Caution in Other Conditions

  • Individuals with liver and kidney diseases should exercise caution while using Diacerein as it might increase the risk of adverse effects. Elderly patients and individuals with inflammatory bowel diseases should also use this medication carefully.

Special Dietary and Lifestyle Recommendations

  • Weight control is essential as excess weight can put extra pressure on weight-bearing joints, worsening the symptoms of osteoarthritis.

  • Avoid activities that strain affected joints.

Frequently asked questions

As a symptomatic slow-acting medicine for osteoarthritis (SYSADOA), the full effects of Diacerein may take several weeks to appear.

No, Diacerein is not a steroid. It belongs to the class of medications known as anthraquinones.

Yes, a prescription from a registered medical practitioner is typically required to purchase Diacerein.

Diacerein should be taken as per the dosage prescribed by your doctor.

Diacerein should be taken orally with meals as directed by your doctor.

There is no evidence suggesting that Diacerein directly impacts sleep patterns. However, if you experience any unusual changes, consult with your doctor.

No known evidence suggests that Diacerein directly affects fertility in men or women.

Terms & Conditions


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