Degarelix
Uses of Degarelix
Degarelix is primarily used to manage advanced prostate cancer in men and belongs to the class of medicines known as gonadotropin-releasing hormone (GnRH) receptor antagonists.
It is also employed, sometimes in combination with radiotherapy, in the management of high-risk localised or locally advanced prostate cancer.
Side effects of Degarelix
Injection site reactions (pain, redness, swelling)
Hot flashes
Weight gain
Fatigue
Elevation in liver enzymes
How Degarelix works
Degarelix is a type of gonadotropin-releasing hormone (GnRH) receptor antagonist.
It functions by attaching itself to the GnRH receptors within the pituitary gland blocking the release of luteinising hormone (LH) and follicle-stimulating hormone (FSH). By inhibiting LH's secretion, Degarelix rapidly reduces testosterone levels to very low amounts, effectively depriving prostate cancer cells of this growth-promoting hormone. Unlike other GnRH agonists, Degarelix does not cause an initial surge in testosterone levels. This makes it effective in quickly reducing the amount of testosterone in the body without causing a temporary increase before the reduction.
Certified content
Written By
Doctor of Medicine
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Degarelix is available in the form of a powder that is meant for reconstitution (injection).
Age and Dose Restrictions
This medication is meant for adult males, specifically those diagnosed with advanced prostate cancer.
Contraindications
Degarelix is contraindicated in patients with known hypersensitivity to the medicine or any of its components. It should be used with caution in patients with a history of long QT syndrome or cardiovascular disease.
Other Medications to Avoid
Degarelix can interact with medicines that may prolong the QT interval, such as certain antiarrhythmics (like amiodarone and sotalol), antipsychotics (like haloperidol and chlorpromazine), and antibiotics (like ciprofloxacin and erythromycin).
Overdose and Missed Dose
Overdose of Degarelix may result in symptoms such as nausea, vomiting, increased heart rate, or changes in blood pressure. If you experience any of these symptoms, contact your doctor immediately.
If you miss a dose of this medicine, inform your doctor promptly. Your doctor will determine when the next dose should be given to maintain consistent testosterone suppression.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage injection site reactions, apply a cold compress to the area after administration.
Hot flashes can be managed by avoiding triggers like caffeine and spicy foods.
Regular rest and maintaining hydration can help manage fatigue.
Use in Driving and Operating Machinery
There is no known effect of Degarelix on the ability to drive or operate machinery. However, if you feel dizzy or unwell after administration, avoid these activities until you feel better.
Use in Pregnancy and Lactation
Degarelix is not meant for use in women.
Caution in Other Conditions
Patients with electrolyte abnormalities should exercise caution when taking Degarelix as it may prolong the QT interval.
Those with heart conditions should use Degarelix carefully, as it may influence heart function and blood pressure.
Patients with osteoporosis should be cautious, as Degarelix may impact bone density over time.
Special Dietary and Lifestyle Recommendations
Frequent hydration is recommended as hormone therapy can sometimes cause feelings of dryness or dehydration.
Ensure adequate intake of calcium and vitamin D to support bone health, as Degarelix may impact bone density over time.
Regularly check electrolyte levels, as Degarelix can affect these and potentially prolong the QT interval.
Frequently asked questions
Does Degarelix have any impact on mood?
Degarelix may cause mood changes like depression or irritability; inform your doctor if you experience significant mood alterations while on this medication.
Can Degarelix cause weight gain?
Yes, weight gain is one of the common side effects reported with the use of Degarelix. Regular exercise and a balanced diet can help manage this side effect. It is advisable to consult your doctor for guidance on managing weight gain while on this medication.
Is it safe to take natural supplements along with Degarelix?
While some natural supplements may be safe to take with Degarelix, others may interfere with its effectiveness or lead to adverse reactions. Always consult your doctor before starting any new supplement or medication.
How quickly does Degarelix start working?
Degarelix starts working rapidly, reducing testosterone levels to low levels within 1-3 days of administration.
Can I stop taking Degarelix if I feel better?
Do not stop taking Degarelix without your doctor's approval, as abrupt discontinuation can cause a rise in testosterone levels and worsen prostate cancer symptoms.
Does Degarelix have any effect on bone health?
Long-term use of Degarelix can lead to bone loss or osteoporosis. Regular monitoring and preventive measures such as adequate calcium and vitamin D intake are recommended.
Can Degarelix affect blood glucose levels?
Degarelix does not usually affect blood glucose levels directly, but it may cause changes in body weight or metabolism that could indirectly impact blood glucose control.
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