Deferasirox
Uses of Deferasirox
The primary use of Deferasirox is to manage chronic iron overload due to frequent blood transfusions in patients 2 years of age and older and in patients with non-transfusion-dependent thalassemia syndromes. It belongs to the group of iron chelator medicines.
Secondary uses of Deferasirox include managing chronic iron overload in individuals who do not require blood transfusions but have conditions that lead to iron accumulation.
Side effects of Deferasirox
Diarrhoea
Vomiting
Nausea
Abdominal pain
Skin rash
How Deferasirox works
Deferasirox is an oral iron chelator.
It works by latching onto excess iron in the bloodstream and successfully removing it from the body. This primarily happens through excretion in faeces, which in turn helps to decrease the levels of excess iron in patients who either have frequent blood transfusions or conditions that cause an accumulation of iron.
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Written By
BDS, MDS
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Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Deferasirox can be taken orally (tablet and film-coated tablet).
Age and Dose Restrictions
This medication has been approved for use in adults and children aged 2 years and above.
Contraindications
Deferasirox should not be given to patients with an estimated glomerular filtration rate (GFR) less than 40 mL/min/1.73 m2. It is also contraindicated in patients with poor performance status, high-risk myelodysplastic syndromes, advanced malignancies, and platelet counts less than 50 x 109/L. Additionally, it is not recommended for those with known hypersensitivity to Deferasirox or any of its components.
Other Medications to Avoid
Deferasirox may interact with CYP1A2 substrates (such as theophylline and caffeine), bile acid sequestrants (like cholestyramine), potent UGT-inducing medications (such as rifampicin), and CYP3A4 substrates (like midazolam).
Overdose and Missed Dose
Overdose of Deferasirox can cause severe symptoms that need immediate medical attention. If such a situation arises, please consult your doctor immediately.
If you miss a dose of Deferasirox, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow the regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless, and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage some gastrointestinal side effects like nausea and vomiting.
Taking the medication on an empty stomach may reduce the risk of gastrointestinal side effects.
Use in Driving and Operating Machinery
Deferasirox may cause dizziness or sleepiness in some patients. It is advisable not to drive or operate heavy machinery if you experience these symptoms.
Use in Pregnancy and Lactation
Deferasirox may cause harm to the fetus when administered to a pregnant woman. It is recommended to consult your doctor before using this medication during pregnancy or lactation.
Caution in Other Conditions
Patients with impaired renal function should exercise caution when taking Deferasirox as it may worsen their condition.
Similarly, patients with liver disease should consult their doctor before starting this medication.
Special Dietary and Lifestyle Recommendations
Regular follow-up with your doctor is needed to monitor your serum ferritin levels.
Frequently asked questions
Is Deferasirox considered a steroid?
No, Deferasirox is not a steroid. It is classified as an iron chelator medicine. It helps manage chronic iron overload in the body by binding to the excess iron and removing it.
Can Deferasirox cause sleep disturbances?
Though sleep disturbances are not commonly reported as side effects of Deferasirox, individual reactions to any medication can vary. If you experience any unusual sleep patterns after starting Deferasirox, you should consult your doctor.
Does Deferasirox affect fertility in individuals?
Deferasirox does not affect fertility. However, if you have concerns about this, it is best to discuss them with your doctor.
Can Deferasirox be taken daily?
Yes, Deferasirox is usually taken as recommended by your doctor based on your condition and needs.
How fast does Deferasirox start working?
Deferasirox starts working soon after ingestion, reaching peak concentrations in the blood within 1.5 to 4 hours. However, the duration to see significant improvement in iron levels varies between individuals and depends on the severity of the iron overload.
When is the best time to take Deferasirox?
Deferasirox should be taken as directed by your doctor, preferably at the same time each day, at least 30 minutes before a meal.
How long do patients generally need to take Deferasirox?
The duration of treatment with Deferasirox can vary greatly between individuals. It is often a long-term therapy, and the duration will depend on factors such as the degree of iron overload and how the body responds to the medicine.
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