Darunavir

Expert Advice

Dosage forms available

• Darunavir is available in tablet form for oral administration.

Age and dose restrictions

• This medicine is suitable for both adults and children aged 3 years and older.

Contraindications

• Darunavir is contraindicated in patients with severe hepatic impairment.

• It should not be used by individuals who are hypersensitive to any component of the formulation.

Other medications to avoid

• This medicine can interact with HIV protease inhibitors (such as ritonavir), alpha blockers (such as alfuzosin), HMG CoA reductase inhibitors (such as lovastatin and simvastatin), phosphodiesterase type 5 inhibitors (like sildenafil when used for pulmonary arterial hypertension), benzodiazepines (such as midazolam and triazolam), herbal supplements containing St. John's wort, and medications for migraine headaches like ergot derivatives like ergotamine.

Overdose and missed dose

• In cases of overdose, supportive care should be provided. Monitoring vital signs and observing clinical status are crucial as dialysis is not beneficial due to high protein binding of the medicine.

• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Management of side effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If you experience mild nausea or diarrhoea, try taking your medication with food or adjusting the timing of your dose.

• Staying hydrated by drinking plenty of water can help manage minor side effects like dry mouth or lightheadedness.

Use in driving and operating machinery

• This medicine may cause dizziness or increased tiredness in some individuals. It is advisable to avoid driving or operating heavy machinery if such symptoms occur.

Use in pregnancy and lactation

• The use of Darunavir during pregnancy should only be considered if the potential benefits outweigh the risks. Consulting a doctor is crucial in this case.

Caution in other conditions

• Caution is advised when administering this medicine to patients with existing liver conditions such as hepatitis B or C, as they are at increased risk for severe liver-related side effects.

• Patients with a history of severe skin reactions or those who develop skin rashes should also use this medicine with caution.

Special dietary and lifestyle recommendations

• It is recommended to limit intake of high-fat meals, which might influence the effectiveness of Darunavir.

• Engage in safe sexual practices to prevent the transmission of HIV despite ongoing treatment. Use barrier methods such as condoms during all sexual encounters.

• Regular follow-ups with your doctor are essential to monitor your health status and make any necessary adjustments to your treatment plan.

Frequently asked questions

Terms & Conditions