Dacarbazine
Uses of Dacarbazine
The principal use of Dacarbazine is for managing various types of cancer, including metastatic malignant melanoma, Hodgkin's lymphoma, and pancreatic islet cell cancer. It belongs to a class of medications known as alkylating agents.
Side effects of Dacarbazine
Nausea and vomiting
Hair loss
Fatigue
Diarrhoea
Mouth and throat sores
How Dacarbazine works
Dacarbazine is an anticancer medicine.
It belongs to a group of medicines known as alkylating agents, well-known for their unique action against cancer cells. Principally, Dacarbazine impedes the growth of these harmful cells by damaging their DNA. Damaging DNA leads to errors when the DNA is copied, which stops the cancer cells from growing and dividing.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Dacarbazine can be administered intravenously (injection).
Age and Dose Restrictions
Dacarbazine is suitable for adults and children aged 12 years and above.
Contraindications
Dacarbazine is contraindicated in individuals who have a known hypersensitivity to the medication. People with severe liver disease should not use Dacarbazine.
Other Medications to Avoid
Dacarbazine may interact with immunosuppressants (cyclosporine, tacrolimus) and certain antibiotics (like streptomycin, neomycin).
Overdose and Missed Dose
If you suspect an overdose of Dacarbazine, it is crucial to seek immediate medical attention. Overdose may result in severe side effects such as nausea, vomiting, diarrhoea, fever, and chills.
If you miss a dose of Dacarbazine, it should be administered as soon as possible. However, if the next scheduled dose is near, the missed one should be skipped. Double dosing should be avoided.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage side effects like nausea and vomiting.
Fatigue can be managed by taking short naps or rest breaks throughout the day.
Use in Driving and Operating Machinery
Dacarbazine may cause dizziness or fatigue. Until you know how this medication affects you, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
Dacarbazine should only be used during pregnancy when needed after discussing the potential risks and benefits with the doctor. It is advisable to consult your doctor before breastfeeding while receiving Dacarbazine treatment.
Caution in Other Conditions
Patients with liver disease need to exercise caution while using Dacarbazine as it can cause liver damage.
Those with bone marrow suppression should also be careful, as Dacarbazine can cause a decrease in the number of blood cells in the bone marrow.
Special Dietary and Lifestyle Recommendations
Avoid sun exposure as Dacarbazine can make your skin more sensitive to sunlight.
Adequate rest is crucial to counter fatigue associated with cancer treatment. It is advisable to balance activity with rest breaks throughout the day.
Frequently asked questions
Is Dacarbazine a steroid?
No, Dacarbazine is not a steroid. It is an anticancer medication.
Does Dacarbazine have any effect on sleep?
Dacarbazine is not typically associated with affecting sleep. However, side effects such as fatigue may indirectly affect your sleep pattern.
Will Dacarbazine affect fertility?
Dacarbazine might have an impact on fertility due to its action on rapidly dividing cells, including reproductive cells. However, it is best to consult your doctor for accurate information.
Is it safe to administer Dacarbazine daily?
The frequency of administration for Dacarbazine depends on the specific treatment plan decided by your doctor. It is crucial to administer the medicine as prescribed by your doctor.
How much time does Dacarbazine take to work?
The time taken by Dacarbazine to show its effect can vary depending on the type and stage of cancer being managed. Your doctor would be able to give you a more accurate timeframe.
What is the best time to take Dacarbazine?
Dacarbazine is administered by a healthcare professional through intravenous injection at scheduled times decided by your doctor.
Is Dacarbazine available over the counter, or do I need a prescription?
Dacarbazine is an anticancer medication that requires a prescription from a doctor. It is not available for purchase over the counter.
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