Dabigatran Etexilate
Uses of Dabigatran Etexilate
- Dabigatran Etexilate is primarily used to decrease the risk of stroke and blood clots in patients with a serious heart rhythm problem called non-valvular atrial fibrillation. It is an anticoagulant medication that helps prevent stroke and systemic embolism in adult patients.
- Additionally, it is indicated for managing deep vein thrombosis (DVT) and pulmonary embolism (PE), reducing the risk of recurrence of DVT and PE, and serving as a preventive measure against DVT and PE in adult patients who have undergone hip replacement surgery.
Side effects of Dabigatran Etexilate
Bleeding
Gastrointestinal problems such as stomach pain and nausea
Anemia
Allergic reactions
Gastritis-like symptoms
How Dabigatran Etexilate works
Dabigatran Etexilate is an anticoagulant.
It is a prodrug, which means it is inactive when taken but converts into its active form, called dabigatran, inside the body. Dabigatran directly inhibits an enzyme called thrombin. Thrombin plays a crucial role in the formation of blood clots. So, by blocking its action, Dabigatran Etexilate helps to prevent the formation and growth of dangerous blood clots. In addition to stopping clots forming in the blood vessels, it also inhibits free thrombin, fibrin-bound thrombin and thrombin-induced platelet aggregation. This further helps to reduce the risk of problematic clotting events such as strokes or embolisms.
Certified content
Written By
MD Ayurveda
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Dabigatran Etexilate can be taken orally (capsule).
Age and Dose Restrictions
Dabigatran Etexilate is meant for adults who are 18 years old and older.
Contraindications
Dabigatran Etexilate is contraindicated in patients with a history of serious hypersensitivity reaction to Dabigatran Etexilate. It is not to be used in patients with active pathological bleeding or in those with mechanical prosthetic heart valves.
Other Medications to Avoid
Dabigatran Etexilate may interact with P-glycoprotein (P-gp) inducers (such as rifampin), and P-gp inhibitors (like dronedarone or systemic ketoconazole).
Overdose and Missed Dose
An overdose of Dabigatran Etexilate may result in symptoms such as unusual bleeding or bruising. If an overdose is suspected, seek immediate medical attention.
If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and return to your normal schedule. Avoid doubling the dose.
Management of Side Effects
Most side effects of Dabigatran Etexilate are temporary and resolve once you stop taking the medicine. However, if you experience any severe side effects or worsening symptoms, consult your doctor.
To manage upset stomach, take this medication with food.
Drinking plenty of water may help reduce the risk of blood clots and aid in mitigating potential adverse effects.
Use in Driving and Operating Machinery
Dabigatran Etexilate may sometimes cause dizziness. If you feel dizzy after taking this medication, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
Dabigatran Etexilate should only be used during pregnancy if the potential benefit justifies the potential risk to the foetus. Breastfeeding mothers should consult a doctor before using this medicine as it's not recommended during lactation.
Caution in Other Conditions
Dabigatran Etexilate should be used with caution in patients with renal impairment as it may impact its effectiveness. The dosage should be adjusted in accordance with the patient's kidney function.
Special Dietary and Lifestyle Recommendations
To manage conditions such as atrial fibrillation and deep vein thrombosis for which Dabigatran Etexilate is prescribed, it's crucial to follow a heart-healthy diet low in saturated fat, cholesterol, and sodium.
Frequently asked questions
How long does Dabigatran Etexilate stay in the system?
Dabigatran Etexilate stays in the body for approximately 12 to 17 hours. However, this can vary depending on several factors such as your age, health, and kidney function.
Can I stop taking Dabigatran Etexilate abruptly?
No, you should not stop taking Dabigatran Etexilate abruptly without consulting your doctor as this may increase your risk of developing a blood clot or having a stroke.
Can Dabigatran Etexilate cause weight gain?
Weight gain is not a common side effect of Dabigatran Etexilate. If you notice any unusual changes in your weight while taking this medication, consult your doctor.
Is Dabigatran Etexilate safe for long-term use?
Dabigatran Etexilate is generally considered safe for long-term use under the supervision of a doctor. However, continuous monitoring of renal function and regular check-ups are required when using this medication for a prolonged period.
Is Dabigatran Etexilate a steroid?
No, Dabigatran Etexilate is not a steroid. It belongs to the class of medicine known as direct thrombin inhibitors.
Can Dabigatran Etexilate affect sleep?
Dabigatran Etexilate is not associated with affecting sleep. However, if you experience any change in your sleeping pattern after starting this medicine, you should consult your doctor.
Does Dabigatran Etexilate influence fertility?
Dabigatran Etexilate is not associated with affecting human fertility. Consult your doctor for any concerns.
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