Crisaborole
Uses of Crisaborole
Crisaborole is primarily used to manage mild to moderate atopic dermatitis (eczema) in adults and children aged 3 months and older. It belongs to the category of medications known as phosphodiesterase-4 (PDE-4) inhibitors.
Side effects of Crisaborole
Burning or stinging at the application site
Skin redness, itching, swelling
Hives
How Crisaborole works
Crisaborole is a phosphodiesterase-4 (PDE-4) inhibitor.
It works by blocking the action of PDE-4, an enzyme found within cells that can cause inflammation when it is too active.
By inhibiting or "blocking" this enzyme helps to increase the levels of a substance called cyclic adenosine monophosphate (cAMP) within cells. This increase in cAMP helps to reduce inflammation, which in turn helps to alleviate symptoms of atopic dermatitis such as itching, redness, and rashes.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Crisaborole is available for use as an ointment, which is applied topically to the skin.
Age and Dose Restrictions
Crisaborole ointment is intended for use in adults and children starting from 3 months of age.
Contraindications
Crisaborole ointment is contraindicated in patients with a known hypersensitivity to Crisaborole or any component of the formulation.
Other Medications to Avoid
Crisaborole may interact with cytochrome P450 inhibitors, such as fluvoxamine (an antidepressant) and ciprofloxacin (an antibiotic), which might affect the metabolism of crisaborole.
Overdose and Missed Dose
An overdose of Crisaborole is unlikely as it is intended for external use only. Using the prescribed dosage is recommended to avoid any side effects.
If you miss a dose of Crisaborole, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra ointment to make up for a missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If you experience mild irritation at the application site, consider applying the ointment at a different time of day.
Staying hydrated may help alleviate any minor irritation.
Use in Driving and Operating Machinery
Crisaborole does not affect your ability to drive or operate machinery.
Use in Pregnancy and Lactation
Consult your doctor before using Crisaborole if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients who have severe inflammation or broken skin should consult their doctor before using Crisaborole due to the potential for increased systemic absorption.
Special Dietary and Lifestyle Recommendations
Maintain a regular moisturising routine to help manage symptoms of atopic dermatitis.
Wear loose, soft clothing that does not irritate the skin.
Avoid known allergens and irritants that may trigger eczema flareups.
Try to manage stress through relaxation techniques like yoga or meditation, as stress can exacerbate atopic dermatitis.
Keep nails short to prevent skin damage from scratching.
Consider using a humidifier in dry environments to help keep skin moisturised.
Frequently asked questions
Is Crisaborole a steroid?
No, Crisaborole is not a steroid. It belongs to a class of medicines known as phosphodiesterase-4 (PDE-4) inhibitors and it is used for managing mild to moderate atopic dermatitis, also known as eczema.
Does taking Crisaborole have any effect on sleep?
There is no evidence from the provided data that Crisaborole directly affects sleep. However, by managing itching and redness associated with atopic dermatitis, it might indirectly improve sleep quality in affected individuals.
Will using Crisaborole affect fertility?
There is no available data suggesting that Crisaborole could affect fertility in men or women.
Are there any particular diet restrictions while using Crisaborole?
No specific diet restrictions are required while using Crisaborole. However, if you have any concerns about your diet while taking this medication, consult your doctor for advice.
Is it safe to use Crisaborole daily?
Yes, it is safe to use Crisaborole daily as directed by your doctor. It is typically applied twice daily to the affected area(s) but dosage will purely depend on your condition. Please consult your doctor.
How much time does Crisaborole take to show improvement?
The exact time for noticeable improvement can vary depending on the individual's skin condition and response to therapy. However, it is advisable to use the medication as prescribed by your doctor consistently for optimum results.
Do I need a prescription to buy Crisaborole?
Yes, you typically need a prescription from a doctor to buy Crisaborole. It is not an over-the-counter medicine.
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