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Cisapride + Simethicone

Uses of Cisapride + Simethicone

  • Cisapride + Simethicone is used to manage gastrointestinal disorders. It belongs to the class of gastroprokinetic and antifoaming agents.

  • It is also indicated for relief of symptoms such as bloating, fullness, pressure in the stomach, and discomfort caused by excess gas.

Side effects of Cisapride + Simethicone

  • Diarrhoea

  • Headache

  • Abdominal pain

  • Nausea

  • Dizziness

How Cisapride + Simethicone works

  • Cisapride + Simethicone is a prokinetic and antifoaming combination.

  • Cisapride acts on serotonin 5-HT4 receptors, which are present in the gut wall. This action stimulates the release of acetylcholine, a chemical messenger. This leads to an increase in pressure in the lower oesophagus, enhances movement of food along the food pipe, speeds up the emptying of the stomach, and accelerates transit in the intestines. In simple terms, it helps to coordinate movements in the gut.

  • Simethicone acts as a defoaming agent. It reduces the surface tension of gas bubbles in your gut, making them merge into larger bubbles. These larger gas bubbles can be passed more conveniently from your body as belching or flatulence. Despite its action in the gut, Simethicone is not absorbed into the body.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Cisapride + Simethicone is available in oral tablet and oral suspension forms.

Age and Dose Restrictions

  • Cisapride + Simethicone is recommended for use primarily by adults. It is not recommended for children.

Contraindications

  • This combination is contraindicated in individuals with complete mechanical gastrointestinal obstruction.

  • It is also contraindicated in people with severe respiratory disorders.

  • Individuals with known hypersensitivity to any of the components should avoid using it.

Other Medications to Avoid

  • This combination may interact with antibiotics (such as erythromycin and clarithromycin), antifungals (like ketoconazole and itraconazole), antiarrhythmics (such as quinidine and sotalol), antidepressants (like citalopram, tricyclics), anti-psychotics (like thioridazine, ziprasidone), antihistamines (such as astemizole, terfenadine), and HIV protease inhibitors (like ritonavir).

Overdose and Missed Dose

  • Symptoms of overdose might include severe nausea, vomiting, diarrhoea, abdominal cramps, drowsiness, fainting, and disturbed heart rhythm. If an overdose is suspected, seeking emergency medical care is crucial.

  • If a dose is missed, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed one. Do not take a double dose to catch up.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For mild nausea or headaches, consider taking the combination with food or adjusting the timing of doses.

  • Increasing fluid intake may help alleviate mild constipation associated with this combination.

Use in Driving and Operating Machinery

  • Cisapride + Simethicone can cause dizziness or drowsiness in some individuals. It is advisable to avoid driving or operating heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

  • The safety of Cisapride + Simethicone during pregnancy and lactation has not been fully established. It should only be used if the potential benefits justify the potential risk to the foetus or infant. Always consult your doctor before using this combination during pregnancy or while breastfeeding.

Caution in Other Conditions

  • Caution is advised when using Cisapride + Simethicone in patients with a history of heart disease or abnormal heart rhythms.

  • Patients with kidney or liver impairment should also use this medication cautiously.

Special Dietary and Lifestyle Recommendations

  • To manage symptoms of gastrointestinal discomfort such as bloating and indigestion, consider eating smaller, more frequent meals instead of three large meals a day.

  • Avoid foods that are known to increase gas production like beans, cabbage, and onions.

  • Staying hydrated by drinking plenty of water can aid digestion and help manage symptoms of indigestion.

Frequently asked questions

No, this combination does not contain any steroids. It is a combination of a prokinetic agent and an antifoaming agent used to manage gastrointestinal disorders.

There is no evidence to suggest that it affects sleep patterns. However, if you notice any changes in your sleep after starting this medication, please consult your doctor.

There is no scientific data available suggesting that the use of this combination affects fertility in humans. It is always advisable to discuss with your doctor if you are planning to conceive while on this medication.

Generally, there are no specific foods that you must exclude from your diet while taking this combination. It is advisable to maintain a healthy and balanced diet for optimal health benefits.

If recommended by your doctor, it is safe to take this medicine daily. However, long-term usage should be under strict medical supervision.

You should never stop taking it without consulting your doctor as this could worsen your symptoms. Always follow the doctor's instructions regarding the duration and discontinuation of medication.

This combination usually requires a prescription from a doctor and is not generally available over the counter.

Terms & Conditions


Available medicines for CISAPRIDE + SIMETHICONE
Gastro Mps 125/10 MG Tablet 10
Gastro Mps 125/10 MG Tablet 10
Cipla Ltd.
Pack of 10 Units
₹3.55
MRP ₹4.33
18.00% OFF
Moticare Mps 125/10 MG Tablet 10
Moticare Mps 125/10 MG Tablet 10
Organon (india) Ltd
Pack of 10 Units
₹32.80
MRP ₹40.00
18.00% OFF
Cesap Mps 125/10 MG Tablet 10
Cesap Mps 125/10 MG Tablet 10
Dynamic Laboratories Pvt Ltd
Pack of 10 Units
₹28.70
MRP ₹35.00
18.00% OFF
Cisacone 125/10 MG Tablet 10
Cisacone 125/10 MG Tablet 10
Maneesh Pharmaceuticals Ltd
Pack of 10 Units
₹29.73
MRP ₹36.26
18.00% OFF
Biopride Mps 125/10 MG Tablet 10
Biopride Mps 125/10 MG Tablet 10
Chemo Biological
Pack of 10 Units
₹30.34
MRP ₹37.00
18.00% OFF
Alipride Mps 125/10 MG Tablet 10
Alipride Mps 125/10 MG Tablet 10
Centaur Pharmaceuticals Pvt.ltd
Pack of 10 Units
₹29.62
MRP ₹36.12
18.00% OFF
Ciza-mps 125/10 MG Tablet 10
Ciza-mps 125/10 MG Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹47.17
MRP ₹57.53
18.00% OFF

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