Cefuroxime + Sulbactam
Uses of Cefuroxime + Sulbactam
Cefuroxime + Sulbactam is primarily used to manage a wide range of bacterial infections and belongs to the class of antibiotic medicines.
It is also used to manage respiratory tract infections such as pneumonia, bronchitis, and sinusitis, urinary tract infections (UTIs), skin and soft tissue infections, intra-abdominal infections, gynaecological infections, bone and joint infections, and septicemia (bloodstream infection).
Side effects of Cefuroxime + Sulbactam
Nausea and vomiting
Allergic reactions like rashes
Injection site reactions like redness, itching
Headache
Dizziness
How Cefuroxime + Sulbactam works
Cefuroxime, a second-generation cephalosporin, works by inhibiting the synthesis of the bacterial cell wall. It does this by binding to and inactivating enzymes called penicillin-binding proteins (PBPs), which are crucial for the cross-linking of the peptidoglycan layer that forms the bacterial cell wall. When these PBPs are inhibited, the bacterial cell wall is weakened, leading to cell lysis (bursting) and death.
Sulbactam, a beta-lactamase inhibitor, works by inhibiting beta-lactamase enzymes, which are produced by some bacteria to break down beta-lactam antibiotics like cefuroxime. By irreversibly binding to these enzymes, sulbactam prevents them from inactivating cefuroxime, thereby enhancing the antibiotic's effectiveness against beta-lactamase-producing bacteria.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Cefuroxime + Sulbactam can be taken orally (tablet) and administered parenterally, either by intravenous (IV) infusion or intramuscular (IM) injection.
Age and Dose Restrictions
Cefuroxime + Sulbactam is indicated for use in adults and children, with pediatric dosages calculated based on body weight.
Contraindications
Cefuroxime + Sulbactam is contraindicated in patients with known allergies to cephalosporins, penicillins, or beta-lactams. It should also be used with caution in patients with a history of gastrointestinal diseases, especially colitis.
Other Medications to Avoid
Cefuroxime + Sulbactam may interact with aminoglycoside antibiotics (gentamicin, tobramycin), oral anticoagulants ( warfarin, apixaban), uricosurics (probenecid) and live bacterial vaccines.
Overdose and Missed Dose
An overdose of Cefuroxime + Sulbactam may cause neurological excitation, dizziness, confusion, nausea, vomiting, and in severe cases, kidney dysfunction. In case of suspected overdose, seek immediate medical attention.
If you miss a dose of this medication, take it as soon as you remember. However, if it is close to the time for your next dose, then skip the missed dose. Do not double up on doses to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
Drinking plenty of water can help manage some gastrointestinal disturbances such as diarrhoea and nausea.
Resting or lying down can help manage feelings of dizziness.
Avoid spicy and fatty foods, which can aggravate gastrointestinal disturbances.
Use in Driving and Operating Machinery
This medication may cause dizziness or fatigue. If you experience these symptoms, avoid driving or operating heavy machinery after taking this medicine.
Use in Pregnancy and Lactation
Cefuroxime + Sulbactam is not recommended during pregnancy and lactation unless prescribed by your doctor as it falls under pregnancy category B i.e. should be used during pregnancy only if needed and is also excreted in human milk. Consult your doctor before taking this medicine during pregnancy and lactation.
Caution in Other Conditions
Patients with renal impairment or liver disease should exercise caution when using Cefuroxime + Sulbactam. Dosage adjustment may be necessary.
Special Dietary and Lifestyle Recommendations
Maintain adequate hydration to support kidney function, as high doses or prolonged use can affect renal function.
Regularly monitor kidney function if using high doses or if you have pre-existing kidney conditions.
Frequently asked questions
Is Cefuroxime + Sulbactam a steroid?
No, Cefuroxime + Sulbactam is not a steroid. It is an antibiotic medicine combining cefuroxime, a second-generation cephalosporin, with sulbactam, a beta-lactamase inhibitor.
Does Cefuroxime + Sulbactam have any effect on sleep?
Cefuroxime + Sulbactam is not known to cause any alterations to sleeping patterns. However, different people can react differently to medications and if you experience any such issues, consult your doctor immediately.
Will Cefuroxime + Sulbactam affect fertility?
Cefuroxime + Sulbactam does not have any specific effects on fertility. If you have any concerns about fertility related to taking this medication, please consult your doctor.
Is it safe to take Cefuroxime + Sulbactam daily?
Yes, it is highly recommended to follow your doctor’s prescription. The duration of treatment and dosage depends on the type and severity of the infection.
How much time does Cefuroxime + Sulbactam take to work?
After intravenous administration, both cefuroxime and sulbactam reach peak plasma concentrations within 15 minutes. However, the time for observable effects can vary based on the type and severity of the infection.
What is the best time to take Cefuroxime + Sulbactam?
The optimal time to take Cefuroxime + Sulbactam should be decided by your doctor, usually depending on the type and severity of the infection as well as other factors, such as your overall health condition.
Does Cefuroxime + Sulbactam cause weight gain?
Cefuroxime + Sulbactam is not known to cause weight gain directly. If you notice unusual weight changes while taking this medication, consult your doctor for advice.
Cefuroxime + Sulbactam in other salts
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