Ceftazidime + Tazobactam
Uses of Ceftazidime + Tazobactam
Ceftazidime + Tazobactam is primarily used to manage serious infections caused by susceptible bacteria, and it belongs to the group of antibiotic medicines.
Besides its primary use, this medicine is also given for complicated intra-abdominal infections and complicated urinary tract infections including pyelonephritis, hospital-acquired pneumonia, ventilator-associated pneumonia, and aerobic Gram-negative infections where there are limited treatment options available.
Side effects of Ceftazidime + Tazobactam
Diarrhoea
Nausea
Vomiting
Headache
Dizziness
How Ceftazidime + Tazobactam works
Ceftazidime is a third-generation cephalosporin antibiotic. It works by binding to penicillin-binding proteins (PBPs) in the bacterial cell wall, disrupting its formation and leading to the death of the bacteria.
Tazobactam is a beta-lactamase inhibitor. It operates by binding to certain beta-lactamase enzymes produced by resistant bacteria, thereby preventing them from breaking down Ceftazidime. This enhances the effectiveness of Ceftazidime against many bacteria that would otherwise be resistant.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Ceftazidime + Tazobactam can be administered intravenously (injection or infusion).
Age and Dose Restrictions
Ceftazidime + Tazobactam is intended for use in adults, adolescents, and children aged 3 months and above.
Contraindications
This medicine is contraindicated in patients who have previously shown severe hypersensitivity to Ceftazidime, Tazobactam, other cephalosporins, penicillins, or beta-lactamase inhibitors.
Other Medications to Avoid
Ceftazidime + Tazobactam may interact with uricosurics (such as probenecid).
Overdose and Missed Dose
An overdose of this medication may cause neurotoxicity (seizures, encephalopathy). If you suspect an overdose, seek immediate medical attention.
If you forget to administer a dose of this medication, administer it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
Increasing fluid intake can help manage gastrointestinal side effects such as diarrhoea.
Resting in a cool environment can help manage injection site reactions.
Use in Driving and Operating Machinery
Ceftazidime + Tazobactam may cause dizziness. If you feel dizzy after receiving this medication, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
Ceftazidime + Tazobactam should be used during pregnancy and breastfeeding only if needed. It is advisable to consult your doctor before using this medicine during these times.
Caution in Other Conditions
Dosage adjustments of Ceftazidime + Tazobactam are necessary for patients with renal impairment, as both Ceftazidime and Tazobactam are primarily eliminated by the kidneys.
Special Dietary and Lifestyle Recommendations
Ensure proper hygiene practices to prevent further spread of the infection.
Regular monitoring of kidney function may be required, especially in patients with existing renal conditions or those receiving prolonged therapy.
Adequate hydration is important as ceftazidime and tazobactam can be excreted via the kidneys. Ensure sufficient fluid intake unless otherwise directed.
Frequently asked questions
Is Ceftazidime + Tazobactam a steroid?
No, Ceftazidime + Tazobactam is not a steroid. It is a combination of two medicines, which belong to the antibiotics class of medicines.
Does Ceftazidime + Tazobactam have any effect on sleep?
Ceftazidime + Tazobactam is not directly associated with affecting sleep disturbances. Nevertheless, if you experience any sleep-related issues after administering this medicine, you should consult your doctor.
Can Ceftazidime + Tazobactam affect fertility?
Ceftazidime + Tazobactam is not directly associated with affecting fertility. However, if you are trying to conceive and have concerns about this medicine, it is best to consult your doctor.
Can I administer Ceftazidime + Tazobactam daily?
Ceftazidime + Tazobactam should be administered as advised by your doctor, in a hospital setting. The frequency will depend on the type and severity of the infection.
How much time does it take for Ceftazidime + Tazobactam to work?
The time for Ceftazidime + Tazobactam to start working can vary depending on factors like the type and severity of the infection. Your doctor will monitor your condition and adjust the treatment accordingly.
Is Ceftazidime + Tazobactam available over the counter, or do I need a prescription?
Ceftazidime + Tazobactam is a strong antibiotic medication and it is not available over the counter. It should only be taken under the supervision of a doctor and with a valid prescription.
What should I do if Ceftazidime + Tazobactam causes allergic reactions?
If you experience symptoms of an allergic reaction such as rash, itching, swelling, severe dizziness, or trouble breathing while administering Ceftazidime + Tazobactam, you should seek immediate medical attention.
Ceftazidime + Tazobactam in other salts
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