Carboprost
Uses of Carboprost
The primary use of Carboprost is to manage severe postpartum uterine bleeding due to poor uterine tone (atony) when other medications have failed. It belongs to the category of prostaglandin analogue medications.
Additionally, Carboprost can also be used to induce labour for therapeutic abortion in the second trimester of pregnancy when medically necessary.
Side effects of Carboprost
Nausea and vomiting
Diarrhoea
Flushing and sweating
Shivering and fever
Uterine pain and cramping
How Carboprost works
Carboprost is a synthetic analogue of prostaglandin, specifically designed to mimic the action of natural hormones found in the body.
It works by binding to prostaglandin receptors located in the uterine muscle, triggering these muscles to contract vigorously. This rounds up and tightens the uterus, causing blood vessels to narrow and thus reducing the loss of blood. As a result of these strong contractions, in case of severe postpartum bleeding, it aids the uterus to regain its tone after childbirth.
Certified content
Written By
BDS, MDS
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Carboprost can be administered via the intramuscular route (injectable solution).
Age and Dose Restrictions
This medicine is intended for use by women of reproductive age.
Contraindications
Patients with known hypersensitivity to Carboprost or other prostaglandins, as well as those with active cardiac, pulmonary, renal, or liver disease, should not use this medication. It is also contraindicated for individuals with a history of stroke or seizure disorders and should not be used by those with uncontrolled hypertension.
Other Medications to Avoid
Carboprost can interact with oxytocic medicines (e.g., oxytocin and ergot alkaloids), antihypertensives (e.g., lisinopril, amlodipine), and anti-inflammatory medicines (e.g., aspirin, ibuprofen).
Overdose and Missed Dose
Overdose of Carboprost may lead to severe side effects such as excessive uterine tone, decreased uterine blood flow, dizziness, or severe abdominal pain. If you suspect an overdose, you should contact your doctor immediately.
If you miss a dose of this medication, consult your doctor for further instructions. Never double up on doses to compensate for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing Carboprost. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids can help manage gastrointestinal symptoms like nausea and diarrhoea.
Resting in a quiet, dark room may help manage headaches.
Use in Driving and Operating Machinery
Carboprost may cause dizziness or confusion. Patients should avoid driving or operating heavy machinery if they experience these side effects after receiving this medication.
Use in Pregnancy and Lactation
It is crucial to consult a doctor before using Carboprost during pregnancy and lactation as it can induce uterine contractions and potentially lead to abortion or premature birth.
Caution in Other Conditions
Caution is advised in patients with a history of heart problems, asthma, hypertension, kidney and liver disease, jaundice, anaemia, and diabetes.
Special Dietary and Lifestyle Recommendations
Regularly check your blood pressure, especially if you have a history of hypertension, as Carboprost can potentially raise blood pressure.
Opt for a bland, low-fiber diet to minimise gastrointestinal irritation and manage symptoms like nausea and vomiting.
Limit strenuous physical activities immediately following the injection to avoid exacerbating side effects such as severe uterine contractions.
Frequently asked questions
Can Carboprost affect menstruation?
Carboprost can cause vaginal spotting or bleeding as one of its side effects. If you notice such changes, consult your doctor immediately.
Does Carboprost have any impact on mood?
Carboprost is not commonly associated with significant mood changes. However, if you experience mood changes while using this medication, it is advised to consult your doctor.
How long will Carboprost stay in the system after administration?
Carboprost is rapidly metabolised in the body and has a short half-life of 1-9 minutes. It is mainly excreted in the urine as an inactive metabolite and does not accumulate in the body with repeated doses.
Is Carboprost a vegetarian medicine?
Carboprost is a synthetic medication and does not contain any animal-derived components. However, it is always important to check the packaging for other ingredients that may not be suitable for vegetarians or vegans.
Are there any natural alternatives to Carboprost?
While there may be natural substances that have similar effects to prostaglandins, they may not have the same efficacy or safety profile as Carboprost. It is crucial to consult your doctor before taking any alternative treatments.
Is Carboprost a steroid?
No, Carboprost is not a steroid. It is a synthetic prostaglandin analogue medicine.
Will Carboprost affect fertility?
Carboprost does not typically affect long-term fertility. It is used to manage specific conditions during pregnancy, but it does not impact a woman's future ability to conceive.
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