Home/Drugs By Ailments / Calcium-5 Methyltetrahydrofolate + Methylcobalamin + Pyridoxal 5 Phosphate

Calcium-5 Methyltetrahydrofolate + Methylcobalamin + Pyridoxal 5 Phosphate

Uses of Calcium-5 Methyltetrahydrofolate + Methylcobalamin + Pyridoxal 5 Phosphate

  • Calcium-5 Methyltetrahydrofolate + Methylcobalamin + Pyridoxal 5 Phosphate is predominantly used for managing dietary deficiencies of essential B vitamins including folate, vitamin B12, and vitamin B6. It falls under the category of dietary supplements and medical foods.

  • In addition, it can be used for hyperhomocysteinemia, megaloblastic anaemia due to folate deficiency, vitamin B12 deficiency anaemia and neuropathy, and inborn errors of folate, B12, and B6 metabolism. It can also be recommended as an adjunctive treatment for depression and autism spectrum disorders.

Side effects of Calcium-5 Methyltetrahydrofolate + Methylcobalamin + Pyridoxal 5 Phosphate

  • Nausea

  • Bloating

  • Allergic reactions

  • Dizziness

  • Sensory neuropathy

How Calcium-5 Methyltetrahydrofolate + Methylcobalamin + Pyridoxal 5 Phosphate works

  • Calcium-5 Methyltetrahydrofolate + Methylcobalamin + Pyridoxal 5 Phosphate is a combination of essential B vitamins.

  • Calcium-5 Methyltetrahydrofolate, the active form of folate, acts as a coenzyme for many important metabolic pathways. It helps in the synthesis of DNA, metabolism of amino acids, and conversion of a molecule called homocysteine into methionine, an essential amino acid.

  • Methylcobalamin, a form of vitamin B12, participates in maintaining adequate concentrations of methionine by aiding the conversion of homocysteine. It also helps in the metabolism of fatty acids and certain amino acids.

  • Pyridoxal 5 Phosphate, the active form of vitamin B6, is involved in over 150 enzymatic reactions. As a coenzyme, it enables these enzymes to catalyse crucial metabolic reactions including the biosynthesis of neurotransmitters and metabolism of amino acids, lipids, and carbohydrates.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Calcium-5 Methyltetrahydrofolate + Methylcobalamin + Pyridoxal 5 Phosphate is available for oral administration in the form of tablets and capsules.

Age and Dose Restrictions

  • This medicine is meant for use by adults and is not specifically recommended for children unless directed by a doctor.

Contraindications

  • This medicine is contraindicated in patients with a known hypersensitivity to any of its components.

  • It should not be used by individuals having pernicious anaemia or other vitamin B12 absorption issues without appropriate medical supervision.

Other Medications to Avoid

  • This combination may interact with anti-epileptic medications (such as phenytoin, phenobarbital, and primidone), proton pump inhibitors (like omeprazole and pantoprazole), H2-receptor antagonists (such as ranitidine and cimetidine), and metformin.

Overdose and Missed Dose

  • An overdose of this medicine could potentially lead to symptoms such as gastrointestinal discomfort, including bloating and nausea. If you suspect an overdose, it is important to seek medical advice promptly.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If you experience gastrointestinal discomfort, consider taking this medication with food or adjusting the timing of your doses.

Use in Driving and Operating Machinery

  • This medication does not typically affect your ability to drive or operate machinery. However, individual reactions can vary; monitor how you feel after taking this medication before engaging in such activities.

Use in Pregnancy and Lactation

  • The use of this medicine during pregnancy or breastfeeding is not recommended without a doctor's advice. It is best to consult your doctor before taking this medication if you are pregnant or nursing.

Caution in Other Conditions

  • Individuals with severe kidney or liver disease should use this medicine with caution. Monitoring of vitamin levels may be necessary in these conditions to avoid potential complications.

Special Dietary and Lifestyle Recommendations

  • Maintaining a balanced diet rich in natural folates such as leafy greens, fruits, and legumes can support the effectiveness of this medication.

  • Regular physical activity is beneficial for overall health and can aid in managing conditions associated with elevated homocysteine levels.

  • Ensure adequate hydration especially if gastrointestinal side effects such as bloating or indigestion occur.

  • Limiting the intake of alcohol can help manage effectiveness as alcohol consumption can interfere with the metabolism of various B vitamins.

  • Incorporating whole grains and lean proteins into your diet can help provide a balanced nutritional intake which supports overall health conditions that Calcium-5 Methyltetrahydrofolate + Methylcobalamin + Pyridoxal 5 Phosphate are used to manage.

Frequently asked questions

This combination supports overall nerve health, helps in the synthesis of DNA, and aids in reducing homocysteine levels, promoting cardiovascular and neurological health.

It is best taken it with a meal to ensure optimal absorption and to help maintain energy levels throughout the day.

Yes, this combination is typically taken daily to maintain adequate levels of essential vitamins and support overall health, especially for those with deficiencies.

Benefits like improved energy levels and nerve function may be noticed within a few weeks of consistent use, though this can vary depending on individual health conditions.

These components support reproductive health by helping maintain healthy homocysteine levels, which can positively influence fertility, particularly in women.

Yes, these vitamins play a role in neurotransmitter synthesis and may help improve mood and reduce symptoms of depression, especially in individuals with deficiencies.

Yes, this combination is often available over the counter, but it is recommended to consult a doctor to ensure it is suitable for your specific health needs.

Terms & Conditions


Calcium-5 Methyltetrahydrofolate + Methylcobalamin + Pyridoxal 5 Phosphate in other salts

ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEASCORBIC ACID + BIOTIN + CALCIUM PANTOTHENATE + FOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + RIBOFLAVIN + THIAMINE MONONITRATE + ZINC SULPHATEELEMENTAL CALCIUM + L-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)METHYLCOBALAMIN + PREGABALINMETHYLCOBALAMINL METHYL FOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEPREGABALIN + NORTRIPTYLINE + METHYLCOBALAMINGABAPENTIN + METHYLCOBALAMINALFACALCIDOL + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + ELEMENTAL BORON + ELEMENTAL CALCIUM + FOLIC ACID + METHYLCOBALAMINMETHYLCOBALAMIN + THIOCTIC ACIDL METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINDHA + L-METHYLFOLATE + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEDULOXETINE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + ELEMENTAL CHROMIUM + INOSITOL + METHYLCOBALAMINDHA + L-METHYLFOLATE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEL-METHYLFOLATE + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMIN + PREGABALINALPHA LIPOIC ACID + GABAPENTIN + METHYLCOBALAMINBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE MONONITRATE + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + ELEMENTAL CHROMIUM + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENOMETHIONINE + ZINC MONOMETHIONINEALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM POLYNICOTINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENIUM DIOXIDEFOLIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + CHROMIUM PICOLINATE + METHYLCOBALAMIN + OMEGA 3 FATTY ACID + SELENIUM DIOXIDEALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + MYO INOSITOL + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)CITICOLINE + METHYLCOBALAMINELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACID + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DHA / DOCOSAHEXAENOIC ACID + EPA / EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + THIAMINE MONONITRATEBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + L METHYLFOLATE + MAGNESIUM + METHYLCOBALAMIN + VITAMIN K27 + ZINCDHA / DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)ELEMENTAL IRON + FOLIC ACID + METHYLCOBALAMINMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN C / ASCORBIC ACIDD-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDEMETHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 (PYRIDOXINE)D-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 (PYRIDOXINE)L-LEUCINE + PYRIDOXAL 5 PHOSPHATEFERROUS ASCORBATE + FOLIC ACID + METHYLCOBALAMINEPALRESTAT + METHYLCOBALAMINAMITRIPTYLINE + METHYLCOBALAMINFOLIC ACID + L-CARNITINE / LEVOCARNITINE + METHYLCOBALAMINMETFORMIN + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)D CHIRO INOSITOL + L-METHYLFOLATE + METFORMIN + METHYLCOBALAMIN + MYO INOSITOLFOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEL-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEFERROUS BISGLYCINATE + FOLIC ACID + METHYLCOBALAMIN + ZINC BISGLYCINATEFOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDEADENOSYLCOBALAMIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B1 + VITAMIN B2 + VITAMIN B6 (PYRIDOXINE)DIACEREIN + GLUCOSAMINE SULFATE POTASSIUM CHLORIDE + METHYL SULFONYL METHANE + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + FOLIC ACID + METHYLCOBALAMIN + OMEGA 3 FATTY ACIDALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE + VITAMIN B6 / PYRIDOXINE
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