Buserelin
Uses of Buserelin
Buserelin is primarily used to manage endometriosis and belongs to the group of synthetic peptide medications known as gonadotropin-releasing hormone (GnRH) agonists.
It is also used for managing uterine fibroids, advanced prostate cancer, and certain gynaecological disorders. Additionally, it forms part of assisted reproduction techniques.
Side effects of Buserelin
Hot flashes
Headaches
Vaginal dryness
Mood changes
Decreased libido
How Buserelin works
Buserelin is a gonadotropin-releasing hormone (GnRH) agonist.
It initially stimulates the pituitary gland to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This leads to a temporary increase in the levels of oestrogen and testosterone, important hormones for the body's reproductive functions. When Buserelin is administered continuously, it desensitises the pituitary gland, which results in a significant decrease in the production of FSH, LH, oestrogen, and testosterone.
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Expert Advice
Dosage Forms Available
Buserelin is available in various forms of infusion (subcutaneous, intravenous), and intranasal routes.
Age and Dose Restrictions
Buserelin is typically prescribed for adults.
Contraindications
This medicine should not be used in patients with known hypersensitivity to Buserelin or any of its excipients.
Additionally, it is contraindicated in patients who are pregnant or breastfeeding as it may harm the developing baby or pass into breast milk.
Other Medications to Avoid
Inform your doctor on all medicines you are taking including prescription, non-prescription and other supplements to prevent unwanted side effects.
Overdose and Missed Dose
An overdose of Buserelin may lead to symptoms such as dizziness, headache, nausea, and vomiting. In case of suspected overdose, seek immediate medical attention.
If you miss a dose of this medicine, administer it as soon as you remember. However, if it is near the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not administer a double dose to catch up.
Management of Side Effects
Most side effects of Buserelin are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor. Some tips to manage side effects include:
Drinking plenty of fluids to manage headaches.
Regularly moisturising your skin can help manage skin reactions at the injection site.
Taking your dose in the evening may help manage hot flushes that can occur with Buserelin.
Use in Driving and Operating Machinery
This medicine can affect your ability to drive or operate heavy machines. Avoid these activities if you experience dizziness or visual disturbances after taking this medicine.
Use in Pregnancy and Lactation
This medicine is recommended to be used during pregnancy and breastfeeding only if recommended by a healthcare professional. Always consult your doctor before taking this medicine during pregnancy and lactation.
Caution in Other Conditions
Patients with osteoporosis or risk factors for bone loss should use Buserelin with caution due to the potential risk of further bone density loss.
It should also be used with caution in patients with a history of depression or mood disorders and those with liver or kidney disease.
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet to support overall health.
Engage in regular physical activities to keep the body active and reduce stress.
Regular check-ups are recommended to monitor hormone levels and overall health while on this medication.
Frequently asked questions
Is Buserelin a steroid?
No, Buserelin is not a steroid. It is a synthetic peptide medication.
Does Buserelin cause weight gain?
Yes, Buserelin causes weight gain, however, you can help control your weight by eating a healthy diet and being active. Your doctor, nurse, or dietitian can also give you more advice.
Will Buserelin affect fertility?
Yes, Buserelin suppresses ovulation and is a contraceptive, therefore it may affect fertility. However, this effect is reversible and fertility typically returns to normal a few months after stopping the treatment.
Is it safe to take Buserelin daily?
It is safe to take Buserelin daily as per the duration recommended by your doctor. Do not exceed this duration without consulting your doctor.
How much time does Buserelin take to work?
The onset of action of Buserelin is gradual with hormone levels starting to fall within 2-4 weeks, and the maximum effect is usually seen by 8 weeks.
What is the best time to take Buserelin?
The best time to take Buserelin would be as per your doctor's recommendation depending on your medical condition and the formulation that you are using.
Is Buserelin available over the counter, or do I need a prescription?
No, Buserelin is not available over the counter. It requires a prescription from a doctor.
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