Bevacizumab
Uses of Bevacizumab
The primary use of Bevacizumab is to manage several types of cancers. It belongs to the class of monoclonal antibody medications.
It is useful in managing metastatic colorectal cancer, non-squamous non-small cell lung cancer, recurrent glioblastoma, metastatic renal cell carcinoma, persistent or metastatic cervical cancer, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer, and hepatocellular carcinoma.
Side effects of Bevacizumab
High blood pressure
Fatigue
Diarrhoea
Low white blood cell count
Dry, scaling skin
How Bevacizumab works
Bevacizumab is a monoclonal antibody.
It works by attaching itself to a protein called vascular endothelial growth factor or VEGF. Normally, VEGF stimulates the growth of new blood vessels, a process called angiogenesis. Tumours, which are abnormal growths of body cells, require a constant supply of nutrients and oxygen for their growth and spread. They get these from blood vessels. By binding to VEGF, Bevacizumab inhibits the formation of these new blood vessels around the tumour. Consequently, it starves the tumours of their required nutrients and oxygen, thereby slowing down their growth and spread.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Bevacizumab can be administered intravenously (solution).
Age and Dose Restrictions
This medication is primarily meant for adults. Use in children is strictly under a doctor's direction.
Contraindications
This medicine is contraindicated in patients with known hypersensitivity to Bevacizumab or any of its components.
Other Medications to Avoid
Bevacizumab may interact with other antineoplastic agents (like sunitinib) and immunosuppressants (such as tacrolimus or cyclosporine). Patients should inform their doctor about all the medicines they are taking, including any prescription medicines, over-the-counter medicines, vitamins, and herbal supplements while on the course of this medication.
Overdose and Missed Dose
Overdose of Bevacizumab may result in severe complications. In case of suspected overdose, seek immediate medical attention.
If you miss a dose of this medicine, administer it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never double the dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage some side effects such as dry mouth.
Resting and avoiding strenuous activities can help manage fatigue.
Use in Driving and Operating Machinery
Bevacizumab may cause fatigue or dizziness, which may impact your ability to drive or operate machinery safely. Avoid doing so if you experience these side effects after the administration of the medicine.
Use in Pregnancy and Lactation
Bevacizumab may cause foetal harm if used during pregnancy and impair fertility. Effective contraception should be used by women during and for at least 6 months after treatment. Breastfeeding is not recommended during treatment and for 6 months after the last dose.
Caution in Other Conditions
Patients with a history of bleeding problems, blood clots, stroke or mini-stroke, recent major surgery, stomach or intestinal ulcers, diabetes, or high blood pressure should exercise caution when taking Bevacizumab.
Special Dietary and Lifestyle Recommendations
Regular blood pressure monitoring is recommended as Bevacizumab may cause high blood pressure.
Regular follow-up visits are essential to track the progress of the cancer treatment.
Frequently asked questions
Is Bevacizumab a steroid?
No, Bevacizumab is not a steroid. It is a monoclonal antibody medication which is mainly used to manage various types of cancer.
Does Bevacizumab have any effect on sleep?
There are no direct effects of Bevacizumab on sleep. However, side effects such as fatigue may indirectly affect sleep.
Will Bevacizumab affect fertility?
Yes, there can be an impact on fertility with the use of Bevacizumab. This medicine can impair fertility and is not recommended for use during pregnancy.
How much time does Bevacizumab take to work?
The exact time for Bevacizumab to start showing its effects can vary depending on the type of cancer and the individual's response to the medicine.
What is the best time to take Bevacizumab?
Bevacizumab is administered by intravenous infusion under the supervision of a healthcare professional. The timing and frequency of the administration are determined by your doctor.
What is the duration of treatment with Bevacizumab?
The duration of treatment with Bevacizumab varies depending upon the type of cancer and response of the patient to treatment.
Can I buy Bevacizumab over the counter?
No, Bevacizumab is not available over the counter. It is a prescription medication and should be used under the supervision of a doctor.
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