Avibactam + Ceftazidime
Uses of Avibactam + Ceftazidime
Avibactam + Ceftazidime is primarily used to manage complicated infections caused by designated susceptible gram-negative microorganisms. This combination antibiotic belongs to the class of third-generation cephalosporins and beta-lactamase inhibitors.
It is also indicated for managing complicated intra-abdominal infections (cIAIs), complicated urinary tract infections (cUTIs) including pyelonephritis, hospital-acquired bacterial pneumonia (HABP), and ventilator-associated bacterial pneumonia (VABP).
Side effects of Avibactam + Ceftazidime
Nausea
Vomiting
Constipation
Anxiety
Dizziness
How Avibactam + Ceftazidime works
Ceftazidime is a third-generation cephalosporin. It destroys bacteria by hindering the formation of the bacterial cell wall. As a result, the bacteria cannot grow and multiply, which helps to manage the infection.
Avibactam is a non-beta-lactam beta-lactamase inhibitor. It prevents certain enzymes, specifically the Ambler class A, C, and some D enzymes, from breaking down ceftazidime. This ensures that ceftazidime remains effective in fighting against the bacteria.
Together, these components work hand in hand to effectively manage infections caused by susceptible gram-negative microorganisms.
Certified content
Written By
Bachelor of Dental Surgery
Reviewed By
MSc (Applied Genetics)
Expert Advice
Dosage Forms Available
Avibactam + Ceftazidime is available in the form of a powder that is used to prepare a solution for intravenous infusion. It is administered by healthcare professionals via the intravenous route, directly into a vein.
Age and Dose Restrictions
This medicine is meant for adults and children who are 18 years of age or older.
Contraindications
Avibactam + Ceftazidime is contraindicated in patients with known severe allergic reactions to the components of the medicine, including avibactam, ceftazidime, other cephalosporins, or other members of the beta-lactam class.
Other Medications to Avoid
This combination may interact with medicines that are substrates of organic anion transporter 1 (OAT1) and OAT3 kidney transporters (e.g., probenecid).
Overdose and Missed Dose
An overdose of Avibactam + Ceftazidime may result in severe side effects such as nausea, vomiting and related complications. In case of a suspected overdose, immediate medical attention should be sought. Both ceftazidime and avibactam can be removed from the body through hemodialysis.
In case you miss a dose of this medicine, inform your doctor immediately. Do not take an extra dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
If you experience nausea or vomiting after taking this medicine, try taking it with meals or snacks.
To manage constipation, increase your intake of dietary fibre and fluids.
If dizziness occurs, avoid sudden changes in posture.
Use in Driving and Operating Machinery
This medicine may cause dizziness in some patients. If you feel dizzy or otherwise impaired, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
There are no sufficient studies on the use of Avibactam + Ceftazidime during pregnancy. Thus, it should be used only when deemed necessary by your doctor. It is unknown whether avibactam and ceftazidime pass into breast milk. Thus, breastfeeding mothers should consult their doctor before using this medicine.
Caution in Other Conditions
Patients with impaired kidney function should exercise caution when taking Avibactam + Ceftazidime, as dose adjustments may be required based on the degree of renal impairment.
Special Dietary and Lifestyle Recommendations
There are no special dietary and lifestyle recommendations apart from maintaining a balanced diet, staying hydrated, getting enough rest, avoiding smoking and limiting alcohol consumption.
Frequently asked questions
Is Avibactam + Ceftazidime a steroid?
No, Avibactam + Ceftazidime is not a steroid. It is a combination antibiotic medication consisting of ceftazidime, a third-generation cephalosporin, and avibactam, a non-beta-lactam beta-lactamase inhibitor.
Does Avibactam + Ceftazidime affect sleep?
There are no known side effects of Avibactam + Ceftazidime that directly impact sleep. However, some common adverse reactions like anxiety and dizziness might indirectly affect sleep patterns in some individuals.
Will Avibactam + Ceftazidime affect fertility?
There are no known effects of Avibactam + Ceftazidime on human fertility. However, it is always advisable to discuss concerns about fertility with your doctor before starting any new medication.
Are there any particular diet restrictions while using Avibactam + Ceftazidime?
There are no specific dietary restrictions associated with Avibactam + Ceftazidime. However, maintaining a balanced and healthy diet helps to support overall well-being during any course of antibiotic treatment.
Is it safe to take Avibactam + Ceftazidime daily?
The safety of daily administration of Avibactam + Ceftazidime depends on the duration and dosage prescribed by your doctor, based on the type and severity of the infection being managed.
How much time does Avibactam + Ceftazidime take to work?
Avibactam + Ceftazidime starts working soon after administration. However, the exact time varies depending on the severity and type of infection and individual patient factors.
Is the Avibactam + Ceftazidime available over the counter, or do I need a prescription?
Avibactam + Ceftazidime is a prescription medicine. It is not available over the counter and should be taken under the supervision of a doctor.
Avibactam + Ceftazidime in other salts
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