Asparaginase
Uses of Asparaginase
Asparaginase is primarily used to manage acute lymphoblastic leukaemia (ALL). This medicine belongs to a group of chemotherapy medicines known as antineoplastic agents.
Side effects of Asparaginase
Allergic reactions like rash, itching, and fever
Nausea and vomiting
Abdominal pain and cramps
Fatigue and weakness
Increased risk of infections
How Asparaginase works
Asparaginase is an antineoplastic agent or a chemotherapy medicine.
It functions by breaking down asparagine, an amino acid that is essential for the growth and survival of cancer cells in acute lymphoblastic leukaemia (ALL). By reducing the asparagine levels, Asparaginase inhibits the growth of these cancer cells and eventually leads to their death.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Asparaginase can be administered as an injection via intramuscular or intravenous route.
Age and Dose Restrictions
Asparaginase is typically used to manage acute lymphoblastic leukaemia in both adults and children, including infants.
Contraindications
Asparaginase should not be given to patients who have a known allergy to the medication or any of its components. Patients with a history of pancreatitis, liver disease, or blood clotting disorders should be carefully evaluated before receiving this medication.
Other Medications to Avoid
Asparaginase may interact with other chemotherapy medications (such as methotrexate, vincristine), anticoagulants or antiplatelet medicines (like warfarin, aspirin), and live vaccines (such as measles, mumps, rubella).
Overdose and Missed Dose
Overdosing on Asparaginase may result in adverse effects such as severe allergic reactions, pancreatitis, liver toxicity, blood clotting abnormalities, or kidney problems. Immediate medical attention is required in case of a suspected overdose.
If a dose is missed, it should be administered as soon as possible. However, if it is nearly time for the next dose, the missed dose should be skipped. Double dosing must be avoided.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help manage side effects such as nausea and vomiting.
Resting or lying down may help with symptoms of fatigue and weakness.
Use in Driving and Operating Machinery
Asparaginase may cause side effects such as dizziness or fatigue that can affect your ability to drive or operate heavy machinery. It is recommended to avoid such activities if you experience these side effects.
Use in Pregnancy and Lactation
The use of Asparaginase during pregnancy or breastfeeding should only be considered if the potential benefits to the mother outweigh the potential risks to the foetus or infant. It is always important to consult your doctor before using this medicine during pregnancy or while breastfeeding.
Caution in Other Conditions
Patients with pre-existing liver disease, kidney disease, or blood clotting disorders should exercise caution when administering Asparaginase as it may worsen these conditions.
Special Dietary and Lifestyle Recommendations.
Regularly scheduled rest periods can also help manage feelings of fatigue and ensure adequate recovery during treatment.
Frequently asked questions
Does Asparaginase affect sleep?
Asparaginase is not typically associated with affecting sleep. However, fatigue and weakness are common side effects of Asparaginase which might indirectly impact your sleep patterns. Consult your doctor if you experience persistent sleep disturbances while using this medicine.
Can Asparaginase affect fertility?
Asparaginase is a potent chemotherapy medicine and may cause harm to the developing foetus if used during pregnancy. It may also have potential effects on fertility, although this effect can vary from person to person. It is recommended to discuss fertility related concerns with your doctor before starting treatment.
Is it safe to administer Asparaginase daily?
The frequency and duration of administering Asparaginase should be determined by your doctor based on your health condition and response to treatment. It is important to follow the prescribed schedule strictly for optimum results.
How long does it take for Asparaginase to work?
Asparaginase starts working soon after administration by inhibiting the growth of cancer cells. However, the time taken to observe improvement in health conditions varies among individuals and depends on the severity of the disease.
Can I buy Asparaginase over the counter?
No, Asparaginase is a prescription medicine and should be used under the supervision of a doctor. It is not available for purchase over the counter.
Is Asparaginase a steroid?
No, Asparaginase is not a steroid. It belongs to the class of antineoplastic agents or chemotherapy medicines.
Does Asparaginase increase appetite?
Asparaginase is not typically associated with increasing appetite. However, some people may experience changes in their appetite due to the stress of illness or side effects from their treatment.
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