Asenapine
Uses of Asenapine
The primary use of Asenapine is to manage schizophrenia in adults and manic or mixed episodes associated with bipolar I disorder in adults and children between 10 and 17 years old. This medicine belongs to the group of atypical antipsychotic medications.
As a secondary use, it acts as an adjunctive therapy to lithium or valproate for acute manic or mixed episodes related to bipolar I disorder in adults.
Side effects of Asenapine
Increased drowsiness
Dizziness
Restlessness
Numbness in the mouth
Weight gain
How Asenapine works
Asenapine is an atypical antipsychotic.
It works by modulating the activity of various neurotransmitters in the brain, particularly serotonin and dopamine. It acts as an antagonist at several receptor sites, including 5-HT2A (serotonin) and D2 (dopamine) receptors, which helps restore balance to mood and behaviour.
This action can lead to improvements in both positive (e.g., hallucinations) and negative (e.g., lack of motivation) symptoms of schizophrenia
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Written By
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Expert Advice
Dosage forms available
This medicine is available for use in the form of sublingual tablets.
Age and dose restrictions
This medicine is meant for adults and paediatric patients aged 10 years or older.
Contraindications
This medicine is contraindicated in patients with known hypersensitivity to any components of the formulation.
It is also contraindicated in patients with severe hepatic impairment (Child-Pugh C).
Other medications to avoid
It may interact with antihypertensive medicines (such as beta-blockers like atenolol and ACE inhibitors like lisinopril), dopamine agonists (including levodopa, carbidopa and ropinirole), other medicines that cause QTc prolongation (such as amiodarone and sotalol), and CYP1A2 inhibitors (like fluvoxamine) and inducers proton pump inhibitors (such as omeprazole).
Overdose and missed dose
An overdose may lead to symptoms such as extreme somnolence and confusion. In case of an overdose, it is important to seek immediate medical attention. Supportive care, including maintaining an adequate airway, ensuring proper oxygenation and ventilation, and symptom management, is important.
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. Do not take a double dose to make up for the missed one.
Management of side effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking water may help alleviate dry mouth.
In case of dizziness, sit or lie down until the feeling stops.
Use in driving and operating machinery
It may impair your ability to drive or operate heavy machinery. Avoid such activities if you feel drowsy or dizzy after taking this medicine.
Use in pregnancy and lactation
The safety of Asenapine during pregnancy and lactation has not been fully established. Therefore, it is recommended to use this medicine under a doctor’s advice during pregnancy and breastfeeding.
Caution in other conditions
Although dose adjustment based on renal impairment is not necessary, it is prudent for patients with kidney issues to consult their doctor before starting Asenapine.
Special dietary and lifestyle recommendations
Regular physical activity can be beneficial; however, consult your doctor for suitable exercises, especially if experiencing side effects like dizziness or somnolence from Asenapine.
It might be helpful to reduce substances that can exacerbate jitteriness or anxiety, such as caffeine.
Establishing a routine for sleeping can help manage sleep disturbances commonly seen in psychiatric conditions.
Frequently asked questions
Is Asenapine a steroid?
No, it is not a steroid. It belongs to the group of medicines known as atypical antipsychotics.
Does Asenapine Have Any Effect on Sleep?
Yes, it can cause somnolence or drowsiness as one of its side effects. This means it may make you feel sleepy.
Will Asenapine affect fertility?
No, there is no specific information available about the effect of this medicine on human fertility. If you have concerns about fertility, please consult your doctor.
Are There Any Particular Diet Restrictions While Taking Asenapine?
No, specific diet restrictions are necessary while for taking this medicine. However, it is always advisable to maintain a balanced diet while taking any medication.
Is It Safe to take Asenapine daily?
It should be taken exactly as prescribed by your doctor. The safety and effectiveness of daily use will depend on your individual condition and response to treatment.
How Much Time Does Asenapine Take to Work?
The time it takes for it to work may vary depending on the individual and the condition being managed. Always follow your doctor's advice regarding the use of this medication.
Is Asenapine Available Over the Counter, or Do I Need a Prescription?
It is a prescription medication and is not available over the counter.
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