Aripiprazole
Uses of Aripiprazole
Aripiprazole is primarily used for the treatment of various mental health conditions and falls under the category of atypical antipsychotic medications.
It is also used in managing conditions such as schizophrenia (age 13+), acute manic and mixed episodes of bipolar I disorder (age 10+), maintenance treatment of bipolar I disorder (age 18+), adjunctive treatment of major depressive disorder (age 18+), irritability linked with autistic disorder (ages 6-17) and treatment of Tourette's disorder (ages 6-18).
Side effects of Aripiprazole
Headache
Agitation
Insomnia
Restlessness
Slurred speech
How Aripiprazole works
Aripiprazole is an atypical antipsychotic medication.
It functions as a partial dopamine agonist. This means it attaches to dopamine receptors in the brain, stimulating them just enough to reduce excessive dopamine activity associated with mental health disorders. Additionally, this medicine also blocks certain types of serotonin receptors while partially activating others. Serotonin is another neurotransmitter involved in mood regulation and mental balance. By controlling both dopamine and serotonin activity, it helps stabilise the brain's chemical environment. Its unique receptor-binding properties lead to different effects in different conditions. For instance, in schizophrenia, it helps reduce hallucinations and delusions, while in disorders like bipolar disorder and depression, it acts on mood, agitation and motivation.
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Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
- Aripiprazole is available in the forms of tablet, liquid oral solution and intramuscular injection.
Age and Dose Restrictions
- This medicine is approved for use in adults. In paediatric populations, it can be given to children above the age of 6 years for certain conditions like irritability associated with autistic disorder and Tourette's disorder (neurological disorder that causes sudden, repetitive, and involuntary movements or sounds).
Contraindications
- This medicine is contraindicated in patients with dementia-related psychosis due to an increased risk of death. It is also not recommended for patients who have a known allergy to Aripiprazole.
Other Medications to Avoid
- Aripiprazole may interact with strong CYP3A4 inhibitors (such as itraconazole, clarithromycin) or CYP2D6 inhibitors (such as fluoxetine, paroxetine).
Overdose and Missed Dose
- Overdose of Aripiprazole may lead to symptoms such as confusion, agitation, aggression, or unconsciousness. Immediate medical attention should be sought if an overdose is suspected.
- If a dose is missed, it should be taken as soon as it is remembered. However, if it is near the time for the next dose, the missed dose should be skipped and the regular schedule should be continued.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience severe side effects or worsening symptoms, please consult your doctor.
- Drink plenty of water to manage side effects like constipation or dehydration.
- Get enough rest to cope with fatigue or sedation.
Use in Driving and Operating Machinery
- Aripiprazole may cause dizziness, drowsiness, or blurred vision. It is advisable to avoid driving or operating heavy machinery until you know how it affects you.
Use in Pregnancy and Lactation
- Aripiprazole should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. It is excreted in breast milk. Mothers taking this medicine should consult a doctor before breastfeeding.
Caution in Other Conditions
- It is contraindicated in patients with seizure disorders, cardiovascular, or cerebrovascular disease as it may aggravate these conditions. It is also contraindicated in patients who are known slow metabolisers of CYP2D6.
Special Dietary and Lifestyle Recommendations
- Ensure adequate sleep and stress management techniques like relaxation exercises or mindfulness to help manage symptoms of mental health conditions.
Frequently asked questions
How Long Does It Take for Aripiprazole to Start Working?
Aripiprazole might show some effects such as calming of agitation or aggression within 1-2 weeks. However, for conditions like schizophrenia, it may take 4-6 weeks or longer for the full benefits to be experienced. Do not stop taking the medicine early without consulting your doctor.
What Time of Day Should I take Aripiprazole?
Aripiprazole is usually taken once a day, with or without food. If it causes insomnia, your doctor may recommend taking it in the morning. If it causes drowsiness, it may be advisable to take it at bedtime. It is important to take the medicine at the same time each day for maximum effectiveness. Follow your doctor's instructions.
Will I Need Tests While Taking Aripiprazole?
Yes, your doctor will likely order periodic blood tests while you are taking Aripiprazole. These tests can help monitor changes in blood sugar, lipids, blood counts and liver function. An EKG may also be performed to check for any heart rhythm abnormalities.
Are There Any Natural Alternatives to Aripiprazole?
While there might be natural remedies that can help manage symptoms of mental health disorders, none can replace the effectiveness of a prescribed medication like Aripiprazole. It is crucial to consult with your doctor before starting any alternative treatments.
Is It Safe to Take Aripiprazole daily?
Aripiprazole is typically prescribed for daily use in individuals with certain mental health conditions. However, the safety and efficacy of daily use will depend on the individual's health status and their doctor’s recommendation.
Will Aripiprazole Affect Fertility?
There is currently no evidence to suggest that Aripiprazole directly affects fertility in humans. However, if you have concerns about fertility, it would be best to consult with your doctor.
Does Aripiprazole Have Any Effect on Sleep?
Yes, Aripiprazole can have effects on sleep. Some people may experience insomnia while others may feel drowsy or fatigued.
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