Apixaban
Uses of Apixaban
The primary use of Apixaban is to manage and prevent blood clots. It is an anticoagulant medication, being part of the class of medicines known as factor Xa inhibitors.
It is used to decrease the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation. It is also indicated for managing deep vein thrombosis (DVT) and pulmonary embolism (PE) and reducing the recurrence risk of these conditions after initial treatment. Furthermore, it is used to prevent DVT and PE in patients who have undergone hip or knee replacement surgery.
Side effects of Apixaban
Bleeding (for example, gastrointestinal or intracranial)
Anaemia
Nausea
Bruising
Fatigue
How Apixaban works
Apixaban is classified as an anticoagulant, specifically a factor Xa inhibitor.
It functions by selectively blocking factor Xa, an essential enzyme in the blood clotting cascade. This blocking action curbs the production of thrombin, which is crucial in the formation of blood clots.
Certified content
Written By
Doctor of Medicine
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Apixaban is available for oral use in the form of tablets.
Age and Dose Restrictions
Apixaban is meant for adults aged 18 and above.
Contraindications
Apixaban is contraindicated in individuals with active pathological bleeding.
It is also contraindicated for patients with severe hypersensitivity reactions to Apixaban.
Individuals with mechanical prosthetic heart valves should avoid using Apixaban.
Other Medications to Avoid
Apixaban can interact with strong CYP3A4 and P-gp inhibitors (such as ketoconazole, itraconazole, ritonavir) and strong CYP3A4 and P-gp inducers (such as rifampin, carbamazepine, phenytoin).
Overdose and Missed Dose
An accidental overdose of Apixaban may lead to excessive bleeding. If suspected, medical attention should be sought immediately.
In case of a missed dose, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed one and continue with the regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For mild gastrointestinal discomfort caused by Apixaban, taking the medicine after food may help.
Drinking plenty of water can help manage potential dehydration caused by excessive bleeding.
Use in Driving and Operating Machinery
Apixaban may cause dizziness and fatigue. Therefore, patients should avoid driving or operating heavy machinery until they know how the medication affects them.
Use in Pregnancy and Lactation
Apixaban should not be taken during pregnancy; if you're on it and planning a pregnancy or become pregnant, consult your doctor for a safe alternative. Consult your doctor for specific advice before taking this medicine during lactation period
Caution in Other Conditions
Caution is required when using Apixaban in patients with severe renal impairment.
It should also be used with caution in patients with liver disease, as this may increase the risk of bleeding due to impaired coagulation.
Special Dietary and Lifestyle Recommendations
Stress management techniques like yoga, meditation, and deep breathing exercises can help maintain mental well-being and support overall health.
Frequently asked questions
Can Apixaban be taken with food?
Yes, Apixaban can safely be taken with or without food. This means you can take it at a time that suits you, whether during a meal or outside of meal times.
Should I stop taking Apixaban suddenly?
No, you should not stop taking Apixaban suddenly. Discontinuing Apixaban abruptly can increase your risk of developing blood clots and possibly leading to a stroke. However, it is crucial that you consult your doctor.
Can I use Apixaban if I have artificial heart valves?
No, Apixaban is not recommended for use in patients with mechanical prosthetic heart valves. This is because there is an increased risk of clot formation and stroke in these patients.
How soon does Apixaban start working?
The medicine's effect on preventing the formation of blood clots may not be immediate and can take several days to fully show its effect.
Can Apixaban cause drowsiness?
No, Apixaban does not generally cause drowsiness. However, If you experience drowsiness while taking Apixaban, consult your doctor.
Can I experience mood changes while taking Apixaban?
If you notice changes in your mood or mental health while taking this medicine, it is important to inform your doctor as soon as possible.
Are there natural alternatives to apixaban?
It is important to take your prescribed medication and not replace it with natural remedies without consulting your doctor.
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