Anastrozole
Uses of Anastrozole
The primary use of Anastrozole is for managing breast cancer in postmenopausal women. It falls under the class of medications known as aromatase inhibitors.
Apart from this, it serves as an adjuvant treatment for postmenopausal women with hormone receptor-positive early breast cancer, first-line treatment for postmenopausal women with hormone receptor-positive or unknown locally advanced or metastatic breast cancer, and treatment for advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.
Side effects of Anastrozole
Hot flashes
Weakness or fatigue
Joint pain or stiffness
Headache
Nausea and vomiting
How Anastrozole works
Anastrozole is an aromatase inhibitor.
It works by blocking the enzyme aromatase, which is responsible for the production of oestrogen in the body. By inhibiting this enzyme, Anastrozole reduces the amount of oestrogen available, a hormone on which many breast cancers depend for growth. This results in slowing down or even stopping the growth of hormone receptor-positive breast cancer cells.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage forms available
Anastrozole is available for use via oral route (tablet).
Age and dose restrictions
Anastrozole is meant for postmenopausal women.
Contraindications
Anastrozole is contraindicated in patients with known allergies to Anastrozole. This medicine is contraindicated for premenopausal women, pregnant women or those who may become pregnant.
Other medications to avoid
Anastrozole may interact with estrogen-containing products (such as hormone replacement therapy, and birth control pills) and tamoxifen.
Overdose and missed dose
An overdose of Anastrozole can cause severe symptoms such as stomach upset, shortness of breath, and fainting. In such cases, seek immediate medical attention.
If you miss a dose of Anastrozole, take it as soon as you remember. If it's near the time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed one.
Management of side effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For hot flashes or night sweats, try to stay cool by using fans and drinking cold fluids.
Joint pain can be eased by applying heat or cold packs.
Use in driving and operating machinery
Anastrozole may cause dizziness or fatigue which can affect your ability to drive or operate machinery. It is advisable to avoid these activities until you know how this medicine affects you.
Use in pregnancy and lactation
This medicine is not recommended during pregnancy and breastfeeding unless recommended by your doctor. Consult your doctor before using this medicine during pregnancy and breastfeeding.
Caution in other conditions
Patients with a history of heart disease or high blood pressure should exercise caution when taking Anastrozole.
Anastrozole can increase bone loss, therefore patients with osteoporosis or other bone-related health issues should inform their doctor before starting this medication.
Special dietary and lifestyle recommendations
Regular bone density tests may be necessary as Anastrozole can cause bone loss.
Adequate intake of calcium and vitamin D is recommended to maintain bone health.
Regular blood tests may be needed to monitor your cholesterol levels.
Avoid intake of alcohol while on Anastrozole as it may worsen certain side effects.
Frequently asked questions
What is the main use of Anastrozole?
Anastrozole is primarily used for managing breast cancer in postmenopausal women.
Can Anastrozole impact my mood?
Anastrozole can potentially lead to mood alterations such as depression. You should inform your doctor if you experience persistent feelings of sadness or hopelessness.
Is Anastrozole available as an over-the-counter medicine?
No, Anastrozole is a prescription medication and is not available over the counter.
Are there any natural alternatives to Anastrozole?
There are no known natural alternatives to Anastrozole. The medicine has a specific function of reducing the amount of oestrogen in the body to manage hormone-receptor-positive breast cancer.
Does Anastrozole have any effect on menstruation?
Anastrozole is not indicated for premenopausal women, hence it does not have any effect on menstruation.
How long does Anastrozole stay in the body?
The half-life of Anastrozole varies among individuals and your doctor can provide more precise information based on your specific circumstances.
Can I develop an allergy to Anastrozole?
Yes, allergic reactions to Anastrozole are possible, though not common. If you experience symptoms like rash, itching, swelling or dizziness, consult your doctor immediately.
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