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Amisulpride

Uses of Amisulpride

  • Amisulpride is primarily used in the management of schizophrenia. It is an atypical antipsychotic medication.

  • It can also be used off-label at low doses to prevent or treat nausea and vomiting after surgery.

Side effects of Amisulpride

  • Insomnia

  • Anxiety

  • Agitation

  • Movement disorders

How Amisulpride works

  • Amisulpride is primarily used in the management of schizophrenia. It belongs to the class of atypical antipsychotic medicines.

  • At smaller doses, Amisulpride works by blocking certain receptors called dopamine D2/D3 auto receptors located on nerve cells in the brain. This increases the release of dopamine, a chemical messenger that helps transmit signals in the brain.

  • At higher doses, it blocks other types of receptors known as postsynaptic dopamine D2 and D3 receptors, especially in a part of the brain called the limbic system. This reduces the activity of dopamine, helping to balance the levels of this chemical in the brain. The dual action of Amisulpride at different doses helps to manage both positive and negative symptoms of schizophrenia.

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Written By

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Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Amisulpride can be taken orally (tablets) and intravenously (injection).

Age and Dose Restrictions

  • Amisulpride is typically prescribed for adults.

Contraindications

  • Do not take Amisulpride if you are allergic to this medicine or any of its components.

Other Medications to Avoid

  • This medicine may interact with antihistamines (e.g. diphenhydramine, cetirizine), antidepressants (e.g. fluoxetine, sertraline), anticonvulsants (e.g. pregabalin, topiramate), narcotic analgesics (e.g. oxycodone, morphine), and antipsychotics (e.g. quetiapine, haloperidol).

Overdose and Missed Dose

  • An overdose of Amisulpride can lead to symptoms like drowsiness, sedation, coma, low blood pressure, and movement disorders. If you observe these symptoms, inform your doctor and follow their advice.

  • If you forget to take a dose, take it as soon as you remember. But if it's nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. You should not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If you experience symptoms like dry mouth, stay hydrated by drinking plenty of fluids.

  • If you feel drowsy, try taking the medicine at bedtime.

Use in Driving and Operating Machinery:

  • Amisulpride may affect your ability to drive or operate heavy machinery. It is advisable to avoid these activities if you feel dizzy or sleepy after taking this medicine.

Use in Pregnancy and Lactation

  • The use of Amisulpride during pregnancy and breastfeeding is not recommended unless your doctor thinks it is necessary. Always consult your doctor before using this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • If you have kidney or liver problems or cardiovascular diseases, you should exercise caution when taking Amisulpride. Your doctor may need to adjust your dosage accordingly.

  • Those who are taking medicines known as levodopa or dopamine agonists, those with a rare tumour of the adrenal gland known as pheochromocytoma or a tumour of the pituitary gland that produces prolactin (prolactinoma), and those with heart diseases, seizures, or problems with the kidney or liver should take this medicine with caution.

Special Dietary and Lifestyle Recommendations:

  • Maintain a healthy lifestyle to manage your condition more effectively. Include plenty of fruits, vegetables, whole grains, lean proteins, and healthy fats in your meals.

Frequently asked questions

Yes, you need a prescription from a doctor to get Amisulpride.

The time it takes for Amisulpride to work can vary depending on various factors. It's important to follow your doctor's recommendations, as they will consider your condition and response to the medication.

No, it is not recommended to stop taking Amisulpride suddenly without consulting your doctor as it can lead to withdrawal symptoms. Your doctor will advise you on how to gradually reduce your dose.

Store Amisulpride in a cool, dry place, away from direct heat and light. Keep it out of sight and reach of children.

Yes, one of the common side effects of Amisulpride is weight gain. If you notice significant weight changes, consult your doctor.

Amisulpride can increase prolactin levels, which may affect fertility in both men and women. If you're planning a pregnancy or having difficulty conceiving, discuss this with your doctor.

Yes, Amisulpride can cause sexual problems in some people. These may include decreased sexual desire or erectile dysfunction in men. If you experience these or any other sexual problems while taking this medicine, consult your doctor.

Terms & Conditions

Available medicines for AMISULPRIDE
Amalt 50 Tablet 15
Amalt 50 Tablet 15
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₹121.23
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Normenta 100 MG Tablet 10
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Joykem Odt 400 MG Tablet 10
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₹439.52
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Agipride 50 MG Tablet 10
Agipride 50 MG Tablet 10
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Pack of 10 Units
₹58.22
MRP ₹71.00
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Amalt 100 MG Tablet 15
Amalt 100 MG Tablet 15
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Pack of 15 Units
₹204.43
MRP ₹249.30
18.00% OFF
Joykem Odt 300 Tablet 10
Joykem Odt 300 Tablet 10
Alkem Laboratories Ltd.
Pack of 10 Units
₹318.98
MRP ₹389.00
18.00% OFF

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