Abiraterone Acetate
Uses of Abiraterone Acetate
Abiraterone Acetate is primarily used to manage advanced prostate cancer in men and falls under the category of CYP17 inhibitors.
Side effects of Abiraterone Acetate
Fatigue
Joint swelling or discomfort
Hot flush
Diarrhoea
Vomiting
How Abiraterone Acetate works
Abiraterone Acetate is part of the therapeutic category known as CYP17 inhibitors. It works by specifically blocking an enzyme called CYP17. This enzyme plays a vital role in the production of male hormones, known as androgens, in the testicles and adrenal glands. By inhibiting CYP17, Abiraterone Acetate reduces androgen production to extremely low levels. As prostate cancers often rely on androgens to grow, this can slow or even stop the cancer's growth and spread.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Abiraterone Acetate can be taken orally (film-coated or uncoated tablet).
Age and Dose Restrictions
This medicine is meant for adult males aged 18 and above.
Contraindications
Abiraterone Acetate is contraindicated in individuals who have a known allergy to abiraterone acetate or any of its components.
Other Medications to Avoid
Abiraterone Acetate may interact with strong CYP3A4 inducers (like rifampin and phenytoin), strong CYP3A4 inhibitors (like ketoconazole and ritonavir), CYP2D6 substrates (such as codeine, tramadol) and CYP2C8 substrates (such as pioglitazone and repaglinide).
Overdose and Missed Dose
Overdose of Abiraterone Acetate might lead to severe symptoms such as hypertension and hypokalemia. If you suspect an overdose, contact your doctor immediately.
In case you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids will help manage urinary tract infections caused by this medicine.
Use in Driving and Operating Machinery
Abiraterone Acetate can cause fatigue and dizziness, affecting your ability to drive or operate heavy machinery. Avoid such tasks if you experience these side effects.
Use in Pregnancy and Lactation
This medication is not recommended for pregnant and breastfeeding women.
Caution in Other Conditions
Caution is advised for patients with liver disease or a history of cardiovascular disease as this medicine can increase the risk of hepatotoxicity and hypertension.
Special Dietary and Lifestyle Recommendations
Regularly monitoring your blood pressure is recommended.
Regular check-ups with the doctor for liver function tests are recommended to monitor potential hepatotoxicity.
Food can affect the absorption of the drug, so adhering to the prescribed timing of dosage is important.
Maintaining adequate hydration supports overall health and can help mitigate some side effects, such as those related to kidney function.
Grapefruit and grapefruit juice can interact with Abiraterone Acetate and affect its metabolism. It is advisable to avoid grapefruit products while on this medication.
Frequently asked questions
Can Abiraterone Acetate cause a change in appetite?
Abiraterone Acetate is not associated with causing changes in appetite. However, individuals can react differently to medicines, hence if you experience an unusual change in your appetite while taking this medicine, it is advisable to consult your doctor.
Is there a natural alternative to Abiraterone Acetate?
There are no known natural substances that possess the same properties or effectiveness as Abiraterone Acetate. It is an FDA-approved medicine specifically designed to manage prostate cancer.
Will Abiraterone Acetate influence my mood or emotions?
Abiraterone Acetate directly is not associated with influencing mood or emotions, however, every individual’s reaction to medication can vary. If you experience any unusual emotional symptoms while taking this medication, please consult your doctor.
Is there any specific time of the day when Abiraterone Acetate works best?
Abiraterone Acetate should be taken as instructed by your doctor. Usually, it is taken on an empty stomach, at least one hour before or two hours after eating.
Can I take Abiraterone Acetate if I am allergic to other medications?
If you have known allergies to other medications, it is important that you discuss these with your doctor before starting on Abiraterone Acetate. Your doctor will then be able to assess if it is safe for you to take this medication.
Is Abiraterone Acetate a steroid?
Abiraterone acetate is not a steroid, but it affects steroid hormone pathways since it is an androgen biosynthesis inhibitor. Its primary role is not as a steroid replacement or a steroid therapy, but rather as a targeted treatment for prostate cancer by inhibiting the enzyme CYP17, which is crucial for androgen production.
Will I be able to see improvements in my condition right away after starting Abiraterone Acetate?
The exact time frame in which you may see improvements after starting Abiraterone Acetate may vary from person to person. It is important to follow your doctor's advice and attend all scheduled appointments so they can monitor your progress.
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