Abacavir + Lamivudine
Uses of Abacavir + Lamivudine
The primary use of Abacavir + Lamivudine is managing HIV-1 infection in adults and paediatric patients weighing at least 25 kg. It belongs to a class of medicines known as antiretroviral medicines.
Abacavir + Lamivudine can also be used for post-exposure prophylaxis to prevent HIV infection after potential exposure provided the treatment is started within 72 hours of potential exposure.
Side effects of Abacavir + Lamivudine
Nausea
Fatigue
Headache
Diarrhoea
Vomiting
How Abacavir + Lamivudine works
Abacavir + Lamivudine is an antiretroviral combination.
Abacavir belongs to the category of medicines called nucleoside reverse transcriptase inhibitors (NRTIs). It stops the HIV from multiplying by blocking a crucial enzyme called reverse transcriptase, which the virus needs to reproduce itself.
Lamivudine is also a nucleoside reverse transcriptase inhibitor. It works similarly by inhibiting the same enzyme, reverse transcriptase, further preventing the HIV from making more copies of itself.
Together, Abacavir + Lamivudine prevent HIV from spreading and thus help to control the infection.
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Expert Advice
Dosage Forms Available
Abacavir + Lamivudine is available as tablets meant for oral administration.
Age and Dose Restrictions
This medicine is designed for use by adults and children over the age of 12 who weigh at least 25 kg.
Contraindications
Abacavir + Lamivudine is contraindicated in patients who have had a prior hypersensitivity reaction to either abacavir or lamivudine.
Patients who test positive for the HLA-B*5701 allele should not be prescribed this medication.
Other Medications to Avoid
Abacavir + Lamivudine may interact with other antiretrovirals (such as emtricitabine), vasodilators used for pulmonary hypertension (like riociguat), antiviral medicines (such as ribavirin) and opioid medications (including methadone).
Overdose and Missed Dose
An overdose of Abacavir + Lamivudine may lead to serious side effects such as lactic acidosis or liver problems. If you think you have taken too much of this medication, seek medical help immediately.
If you forget to take a dose of Abacavir + Lamivudine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed one. Never take two doses together to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Nausea and vomiting can be managed by taking the medication with food.
Fatigue may be managed by ensuring you get enough rest and sleep.
Headaches can be managed by staying hydrated and resting in a quiet, dark room.
Use in Driving and Operating Machinery
Abacavir + Lamivudine may cause dizziness or fatigue. If you feel dizzy or tired after taking this medicine, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
The use of Abacavir + Lamivudine during pregnancy should be discussed with your doctor to weigh the potential benefits against the potential risks to the foetus.
Consult your doctor before using this medicine during breastfeeding.
Caution in Other Conditions
Patients with kidney problems may need dose adjustments when using Abacavir + Lamivudine.
Patients with liver disease, hepatitis B or C co-infection, or risk factors for liver disease should use this medication with caution.
Special Dietary and Lifestyle Recommendations
Eating a balanced diet can help boost the immune system and manage HIV infection.
Practising safe sex can help prevent the spread of HIV to others.
Regular health check-ups are necessary to monitor your condition and adjust your medication as needed.
Frequently asked questions
Is Abacavir + Lamivudine a type of steroid?
No, Abacavir + Lamivudine is not a steroid. It is a combination of two antiretroviral medicines that are used to manage HIV infection.
Can Abacavir + Lamivudine influence my sleep?
Some individuals might experience insomnia or difficulty sleeping as a side effect of Abacavir + Lamivudine. However, this does not occur in everyone. If you experience persistent sleep disturbances, consult your doctor.
Will Abacavir + Lamivudine impact my fertility?
Abacavir + Lamivudine is not associated with affecting fertility. However, if you have concerns about fertility, please discuss this with your doctor.
How quickly does Abacavir + Lamivudine start working?
Abacavir + Lamivudine starts working soon after it is taken. It helps control the HIV infection by reducing the amount of virus in your body.
Does Abacavir + Lamivudine require a prescription or can I buy it over the counter?
Abacavir + Lamivudine is a prescription medicine. It is important to use it only under the supervision of a doctor.
Can one take Abacavir + Lamivudine safely every day?
Yes, Abacavir + Lamivudine can be taken safely every day as part of an antiretroviral regimen for HIV management. The duration and dosing should be as per the prescription of your doctor.
Does Abacavir + Lamivudine lead to dependency?
No, Abacavir + Lamivudine does not lead to addiction or dependency. It is an antiretroviral medication meant for long-term use as part of an overall HIV management plan.
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