Interstitial cystitis

Interstitial cystitis is a chronic condition that affects millions of people worldwide, causing significant discomfort and impacting their quality of life. In this article, we will delve into the details of interstitial cystitis, also known as bladder pain syndrome, and discuss its symptoms and the need for proper medical care. By understanding this condition better, individuals can take steps towards managing their symptoms and improving their overall well-being.

What is Interstitial cystitis?

Interstitial cystitis, or bladder pain syndrome, is a chronic condition that primarily affects the bladder, causing painful urinary symptoms. The bladder, a hollow, muscular organ responsible for storing urine, becomes inflamed and irritated in individuals with interstitial cystitis. Although the exact cause remains unknown, it is thought to be associated with conditions that trigger inflammation in various organs and parts of the body. Interstitial cystitis can affect people of all ages, sexes, and ethnicities; however, it is more prevalent in women than men. Recognising the symptoms and seeking appropriate medical care is essential for managing this condition and improving quality of life.

Interstitial cystitis/bladder pain syndrome can manifest differently in each individual, with symptoms ranging from mild to severe. Some of the most common symptoms include:

• Pain and discomfort: Individuals with interstitial cystitis may experience pain in the pelvis, bladder, or urethra, which can range from mild discomfort to severe pain.

• Urinary urgency and frequency: A persistent and urgent need to urinate is a hallmark symptom of interstitial cystitis, often resulting in frequent urination, sometimes up to 60 times a day.

• Painful urination: Pain or discomfort while urinating is common in individuals with interstitial cystitis, which can be relieved after urinating.

• Sexual intercourse pain: Interstitial cystitis can cause pain during sexual intercourse, which can be a significant issue for those affected by the condition.

• Flare-ups: Symptoms of interstitial cystitis can flare up in response to common triggers, such as menstruation, sitting for a long time, stress, exercise, and sexual activity.

The exact cause of interstitial cystitis remains unclear, but researchers believe that several factors may contribute to the development of this chronic bladder condition. While the specific triggers vary from person to person, the following are some of the known potential causes of interstitial cystitis:

• Defect in bladder tissue: A defect in the protective lining (epithelium) of the bladder may allow toxic substances present in urine to irritate the bladder wall, leading to inflammation and pain.

• Immune system reaction: An autoimmune reaction, where the body's immune system mistakenly attacks the bladder tissue, is a possible cause of interstitial cystitis.

• Nerve problems: Changes in the nerves that carry bladder sensations can cause pain from events that are not normally painful, such as the filling of the bladder.

• Inflammatory cells: The presence of specific inflammatory cells, like mast cells, which release histamine and other chemicals, may contribute to the symptoms of interstitial cystitis.

• Substances in urine: Certain components in urine that damage the bladder or inhibit the growth of cells in the bladder tissue might play a role in interstitial cystitis development.

In addition to these known potential causes, other factors that may contribute to the development of interstitial cystitis include allergies, vascular diseases, unusual infections not detected by standard tests, and genetic predisposition. While having a family member with IC may increase the risk, it is not definitively proven to be genetic. As research continues, a better understanding of the causes of interstitial cystitis will help develop more targeted therapies for this challenging condition.

Interstitial cystitis/bladder pain syndrome is a chronic condition that affects a significant number of people, with a higher prevalence among women. Here is a breakdown of the key demographics affected by interstitial cystitis/bladder pain syndrome:

• Gender: Approximately 90% of patients diagnosed with interstitial cystitis/bladder pain syndrome are female, making it more common in women than men.

• Age: Most people with interstitial cystitis/bladder pain syndrome receive their diagnosis in their 30s or older, with the risk of developing the condition increasing with age.

While there is no proven way to prevent interstitial cystitis due to its unknown cause, several strategies can help manage and reduce the severity of its symptoms. These include dietary changes, lifestyle modifications, and physical therapy.

1. Dietary changes

• Eliminate or reduce foods that irritate the bladder, such as:

  • Carbonated beverages

  • Caffeine (including chocolate)

  • Citrus products and foods high in vitamin C (e.g., tomatoes, pickled foods)

  • Alcohol

  • Spicy foods

  • Artificial sweeteners and high-acid foods

2. Lifestyle modifications

• Wear loose clothing: Avoid clothing that puts pressure on the abdomen.

• Reduce stress: Use techniques such as visualisation, biofeedback, exercise, warm baths, and mindfulness-based meditation to manage stress, which can exacerbate bladder pain syndrome.

• Stop smoking: Smoking can worsen interstitial cystitis symptoms and contribute to bladder cancer risk.

• Exercise: Engage in easy stretching exercises to help reduce flare-ups of interstitial cystitis symptoms.

• Hydration: Stay hydrated, but avoid triggering substances; water is the best liquid for supporting bladder health in those with interstitial cystitis.

3. Physical therapy

• Pelvic floor physical therapy can help strengthen and relax the muscles of the pelvic floor, reducing painful spasms that are common with interstitial cystitis and helping ease the discomfort of this bladder pain syndrome.

Diagnosing interstitial cystitis, also known as bladder pain syndrome, can be a complex process as there is no single definitive test for the condition. Doctors rely on a combination of medical history, physical examination, and various tests to identify IC and rule out other potential causes of bladder pain and urinary symptoms.

1. Medical history and physical exam

• The first step in diagnosing interstitial cystitis involves a thorough review of the patient's medical history and a physical exam, including a pelvic exam to assess the internal pelvic organs.

2. Urinalysis and urine culture

• Urine tests, such as urinalysis and urine culture, are performed to look for signs of infection, abnormal cells, and other indicators of urinary tract issues.

3. Cystoscopy and bladder wall biopsy

• A cystoscopy procedure allows the doctor to visualise the bladder and urethra using a thin tube with a camera. During this procedure, tissue samples may be taken from the bladder wall for further examination.

4. Hydrodistension and potassium sensitivity test

• In some cases, the bladder may be stretched with fluid during cystoscopy to check for Hunner's lesions, which are painful ulcers found in some interstitial cystitis patients. The controversial potassium sensitivity test may also be performed to assess pain and urgency responses.

5. Imaging tests and urodynamics

• Additional tests, such as ultrasound, MRI, CT scans, and urodynamics, may be used to evaluate the urinary tract and bladder function, helping to rule out other conditions that may cause similar symptoms to interstitial cystitis.

While there is no single cure for interstitial cystitis, a variety of treatments and therapies can be used to manage the symptoms and improve bladder function. The management and treatment of interstitial cystitis often involve a multifaceted approach, tailored to each individual patient's needs and symptom severity.

1. Lifestyle modifications

• Patients with interstitial cystitis are often advised to make dietary changes, such as avoiding trigger foods that may exacerbate symptoms. Keeping a food diary can help identify problematic foods, which may include citrus fruits, tomatoes, chocolate, and spicy dishes.

2. Medication options

• Over-the-counter pain relievers, such as acetaminophen or ibuprofen, can help manage mild to moderate pain associated with interstitial cystitis. Prescription medications, including pentosan polysulfate sodium (Elmiron), antihistamines, and tricyclic antidepressants, may be used to reduce inflammation, relieve pain, and improve bladder function.

3. Bladder instillations and nerve stimulation

• Bladder instillations involve introducing a solution directly into the bladder to help reduce inflammation and pain. Nerve stimulation techniques, such as sacral nerve stimulation or percutaneous tibial nerve stimulation, may be used to modulate the nerves that control bladder function.

4. Pelvic Floor Physical Therapy and Stress Management

• Pelvic floor physical therapy can help relax the muscles around the bladder and reduce pain. Stress management techniques, such as relaxation exercises, deep breathing, and counseling, can help patients cope with the emotional impact of living with a chronic condition like interstitial cystitis.

5. Surgical interventions

• In rare cases, surgical interventions may be considered for patients with severe, treatment-resistant interstitial cystitis. These procedures may include bladder augmentation, urinary diversion, or, as a last resort, bladder removal (cystectomy) with reconstructive surgery.

If you are experiencing symptoms that could be indicative of interstitial cystitis, it is crucial to seek medical advice. Your doctor can assess your symptoms, rule out other potential causes, and recommend suitable interstitial cystitis therapies to help manage your condition.

Some key symptoms to watch for include:

• Persistent pelvic pain: Pain in the pelvic area, lower abdomen, urethra, or vagina that does not resolve on its own

• Frequent urination: Feeling an urgent need to urinate very often, up to 60 times per day in some cases

• Urinary urgency and frequency: Increased need to urinate, especially during the night, which can disrupt sleep

• Painful sexual intercourse: Experiencing pain or discomfort during sexual activity

• Flare-ups: Going through periods where your interstitial cystitis symptoms become more intense or bothersome

To prepare for your appointment, it can be helpful to keep a symptom diary to record all symptoms you experience, even if you are unsure whether they are related to interstitial cystitis. Make a list of all medications, vitamins, and supplements you currently take. Consider bringing a family member or friend to your visit for support and to help remember the information your doctor provides. Jot down a list of your most important questions to ask about interstitial cystitis causes, diagnosis and treatment.