Coeliac Disease Sprue

Coeliac disease sprue is a chronic autoimmune disorder that affects the small intestine, causing inflammation and damage to the villi when gluten is consumed. This condition can lead to a wide range of symptoms and complications, making it essential for individuals with coeliac disease to adhere to a strict gluten-free diet. In this article, we will explore the various aspects of coeliac disease sprue, including its causes, symptoms, diagnosis, and treatment options.

What is Coeliac Disease Sprue?

Coeliac disease sprue is an autoimmune condition in which the body's immune system mistakenly attacks the small intestine when gluten is consumed. Gluten is a protein found in wheat, barley, rye, and other grains. The immune system's reaction to gluten leads to inflammation and damage to the villi, small finger-like projections lining the small intestine. This damage impairs the absorption of nutrients, causing various symptoms and potential complications. Coeliac disease is a genetic condition that can develop at any age, and symptoms may vary significantly from one individual to another.

The symptoms of coeliac disease sprue can vary widely among individuals and may affect different parts of the body. Some common symptoms include:

• Gastrointestinal symptoms: Common gastrointestinal symptoms include chronic diarrhoea, abdominal pain, bloating, and gas. Many individuals may also experience nausea and vomiting. These symptoms result from the body’s inability to properly absorb nutrients due to damage in the intestinal lining.

• Nutritional deficiencies: Coeliac disease can lead to malabsorption of essential nutrients, resulting in deficiencies. Symptoms may include fatigue, weakness, anaemia (often iron-deficiency anaemia), and osteoporosis due to calcium and vitamin D malabsorption.

• Skin conditions: Some individuals develop dermatitis herpetiformis, an itchy, blistering rash associated with coeliac disease. This rash often appears on the elbows, knees, and buttocks and improves with a gluten-free diet.

• Neurological symptoms: Coeliac disease may also present with neurological symptoms, including headaches, migraines, peripheral neuropathy (tingling or numbness in the limbs), and difficulties with concentration or memory, sometimes referred to as "brain fog."

• Reproductive issues: Women with coeliac disease may experience reproductive challenges, including irregular menstrual cycles, infertility, or complications during pregnancy.

• Growth delays in children: In children, coeliac disease can lead to delayed growth and development, including short stature and delayed puberty. This is often due to malnutrition resulting from nutrient absorption issues.

• Behavioural changes: Some individuals, particularly children, may exhibit behavioural changes such as irritability, mood swings, or anxiety, which can be related to nutrient deficiencies or the impact of the disease itself.

Recognising these symptoms is crucial for early diagnosis and effective management through a strict gluten-free diet.

How Does Coeliac Disease Sprue Affect Your Body?

Coeliac disease sprue primarily affects the small intestine, damaging the villi responsible for nutrient absorption. When an individual with coeliac disease consumes gluten, their immune system overreacts, causing injury to the villi and impairing the absorption of vital nutrients. This malabsorption can lead to various health problems, including malnutrition, weakened bones, mood changes, and reproductive issues. The disease can develop at any age, and its impact on the body can vary significantly among affected individuals.

Coeliac Disease Sprue in Children

In children, coeliac disease sprue may present with different symptoms compared to adults. Common manifestations in children include abdominal bloating and pain, chronic diarrhoea, constipation, failure to thrive, fatigue, gas, headaches, and irritability. Children with coeliac disease may also have pale, foul-smelling stools. Additionally, they may experience delayed puberty, short stature, and tooth enamel defects. Early diagnosis and strict adherence to a gluten-free diet are essential for children with coeliac disease sprue to prevent long-term complications and ensure proper growth and development.

The progression of coeliac disease can be categorised into several stages based on the extent of intestinal damage, often assessed using the Marsh Score system. These stages include:

• Stage 0: No signs of coeliac disease; the intestinal tissue appears healthy.

• Stage 1: Increased presence of lymphocytes (antibodies to gluten) in the intestinal lining, which may indicate early stages of the disease or another condition such as food intolerance or inflammatory bowel disease.

• Stage 2: Presence of lymphocytes and crypt hyperplasia, where the grooves between the villi (crypts) become longer than normal. This stage may be associated with dermatitis herpetiformis, a rash related to coeliac disease.

• Stage 3: Villous atrophy, where the villi become flattened, significantly impairing nutrient absorption. This stage is further divided into three sub-stages based on the severity of villous atrophy:

  • Stage 3a: Mild villous atrophy; some villi are flattened, but nutrient absorption is still relatively intact.

  • Stage 3b: Moderate villous atrophy; a significant number of villi are flattened, leading to noticeable nutrient absorption issues.

  • Stage 3c: Severe villous atrophy; most villi are severely flattened, greatly impairing nutrient absorption and leading to severe malnutrition risks.

Coeliac disease sprue is caused by an immune reaction to gluten, a protein found in wheat, barley, rye, and sometimes oats. The exact cause is not fully understood, but it involves the following factors:

• Genetic factors: Individuals with a family history of coeliac disease are at a higher risk of developing the condition.

• Environmental triggers: Consumption of gluten triggers an autoimmune response that damages the villi in the small intestine, leading to malabsorption of nutrients.

When gluten is consumed, the immune system of a person with coeliac disease reacts by attacking the villi, which are crucial for nutrient absorption. This leads to a range of complications that can affect various parts of the body.

Several factors can increase the risk of developing coeliac disease, including:

• Family history

• People with other autoimmune conditions, such as type 1 diabetes, autoimmune thyroid disease, and Addison's disease

• Individuals with these genetic disorders, such as Down syndrome and Turner syndrome

• Certain genetic variations, particularly in the HLA-DQ2 and HLA-DQ8 genes

• Age (between 40 and 60 years)

While having these risk factors does not necessarily mean you will develop coeliac disease, being aware of them can help with early detection and management.

If coeliac disease is left untreated or poorly managed, it can lead to various complications that include:

• Malnutrition: Damage to the small intestine can result in malabsorption of essential nutrients, such as iron, folate, calcium, and vitamin D, leading to deficiencies and related health problems.

• Osteoporosis: Malabsorption of calcium and vitamin D can lead to reduced bone mineral density, increasing the risk of osteoporosis and fractures.

• Infertility and miscarriage: Untreated coeliac disease may contribute to reproductive issues, such as infertility, recurrent miscarriages, and low birth weight babies.

• Neurological problems: Some people with coeliac disease may experience neurological symptoms, such as peripheral neuropathy, ataxia (impaired coordination), and epilepsy.

• Lactose intolerance: Damage to the small intestine can cause temporary lactose intolerance, leading to bloating, diarrhoea, and abdominal pain after consuming dairy products.

• Intestinal cancers: Although rare, people with coeliac disease have a slightly increased risk of developing intestinal lymphoma and small bowel cancer.

Diagnosing coeliac disease typically involves a combination of clinical evaluation, blood tests, and intestinal biopsy. The tests may include:

• Serological tests: Blood tests are used to detect specific antibodies that are commonly present in people with coeliac disease. These tests include tissue transglutaminase (tTG) antibody tests, endomysial antibody (EMA) tests, and deamidated gliadin peptide (DGP) antibody tests. These tests are most accurate when performed while the individual is on a gluten-containing diet.

• Genetic testing: Genetic tests can be used to detect the presence of HLA-DQ2 and HLA-DQ8 genes, which are found in most people with coeliac disease. However, having these genes does not necessarily mean an individual will develop coeliac disease.

• Intestinal biopsy: If blood tests and clinical evaluation suggest coeliac disease, an intestinal biopsy is usually performed to confirm the diagnosis. During this procedure, small tissue samples are taken from the small intestine to examine under a microscope for damage to the villi (small, finger-like projections lining the intestine).

In some cases, a gluten-free diet may be recommended before the biopsy to see if symptoms improve. However, it is crucial to consult with a doctor before starting a gluten-free diet, as it can affect the accuracy of diagnostic tests.

Coeliac disease is a chronic autoimmune disorder that requires careful management to prevent symptoms and complications. The treatment and management options include:

• Gluten-free diet: The primary treatment option for coeliac disease is a strict gluten-free diet, which involves eliminating all sources of gluten found in wheat, barley, and rye. Patients must carefully read food labels and avoid cross-contamination to ensure complete adherence.

• Nutritional supplementation: Individuals with coeliac disease may require nutritional supplementation to address deficiencies caused by malabsorption. Common supplements include iron, calcium, vitamin D, and B vitamins.

• Monitoring and follow-up: Regular follow-up appointments with a doctor are essential to monitor adherence to the gluten-free diet and assess nutritional status. Blood tests may be performed to check for improvement in antibody levels and nutritional deficiencies.

• Managing associated conditions: Patients with coeliac disease may have other autoimmune conditions or related disorders. Management of these conditions, such as thyroid disease or type 1 diabetes, should be coordinated with doctors.

• Long-term health monitoring: Individuals with coeliac disease should undergo regular health assessments to monitor for potential complications, including osteoporosis, intestinal cancers, and other autoimmune diseases.

Living with coeliac disease sprue involves several important considerations, including:

• Adherence to a gluten-free diet is key to managing coeliac disease sprue. This heals the damage to the villi in the small intestine and prevents further damage.

• Seek help from a registered dietitian who specialises in coeliac disease to ensure a balanced and nutritious diet.

• Be aware of hidden sources of gluten in foods, medicines, and non-food products.

• Read labels carefully to identify ingredients that may contain gluten.

• Communicate your dietary needs to friends, family, and restaurant staff to avoid accidental gluten exposure.

• Join support groups or online communities to connect with others who have coeliac disease sprue and share experiences and tips.

If you experience persistent digestive symptoms, such as diarrhoea, abdominal pain, bloating, or unexplained weight loss, consult your doctor. These symptoms may indicate coeliac disease sprue or another digestive disorder. Additionally, if you have been diagnosed with coeliac disease sprue and your symptoms persist or worsen despite following a strict gluten-free diet, consult your doctor to rule out other potential causes or complications.

• Coeliac disease sprue is an autoimmune disorder triggered by the consumption of gluten, a protein found in wheat, barley, rye, and triticale.

• Common symptoms include chronic diarrhoea, abdominal pain, bloating, and unexplained weight loss, but some individuals may be asymptomatic.

• The only effective treatment for coeliac disease is a strict, lifelong gluten-free diet, which helps heal the small intestine and alleviate symptoms.

• Regular follow-up with doctors, dietary counselling, and nutritional monitoring are essential for managing coeliac disease successfully.

• Early diagnosis and treatment are crucial to prevent complications and improve quality of life.